IgG class antibodies from psoriasis patients recognize the 60‐KDa heat‐shock protein of Streptococcus pyogenes

Abstract

Results suggest that a high response to the HSP60Sp could be associated with the chronic form of psoriasis.

Keratinocytes treated with peptidoglycan from Staphylococcus aureus produce vascular endothelial growth factor, and its expression is amplified by the subsequent production of interleukin‐13

“…In psoriasis, bacterial infection seems to play an important role in the etiology of the disease. Several products of Gram-positive bacteria, such as M protein, 28,29 superantigens, 30,31 and heat shock proteins, 32 have been associated with the humoral and cellular immune response of psoriatic patients. Recently, Baker et al 33 have reportedthat, in biopsiesfrompatientswithpsoriasis, there are macrophages containing PGN and T-helper-1 (Th1) cells, which respond specifically to PGN from S. pyogenes.…”

Comparison of expression of heat‐shock protein 60, Toll‐like receptors 2 and 4, and T‐cell receptor γδ in plaque and guttate psoriasis

“…They are highly immunogenic proteins, and it is suggested that they can develop autoimmunity after infection because of the sequence homology between bacteria and human 6 . In one study, Cancino‐Diaz et al 7 found that the serum of patients with psoriasis contained a higher level of antibody to the HSP60 of Streptococcus pyogenes than did the control group. Rambukkana et al 8 showed that the majority of their patients with chronic plaque‐type psoriasis showed strong antibody activity to the recombinant mycobacterium HSP65 7 .…”

“…In one study, Cancino‐Diaz et al 7 found that the serum of patients with psoriasis contained a higher level of antibody to the HSP60 of Streptococcus pyogenes than did the control group. Rambukkana et al 8 showed that the majority of their patients with chronic plaque‐type psoriasis showed strong antibody activity to the recombinant mycobacterium HSP65 7 . HSPs are known to be recognized by γδ T‐cell receptors (TCR‐γδ) and Toll‐like receptors (TLRs) 2 and 4 and consequently alert innate and adaptive immune systems 9,10,11 .…”

“…Rambukkana et al 8 showed that the majority of their patients with chronic plaque-type psoriasis showed strong antibody activity to the recombinant mycobacterium HSP65. 7 HSPs are known to be recognized by gd T-cell receptors (TCR-gd) and Toll-like receptors (TLRs) 2 and 4 and consequently alert innate and adaptive immune systems. 9,10,11 TCRs are glycoproteins expressed on the surface of lymphocytes; TCR-gd in particular is known to react to HSP65.…”

Echinococcosis: A Possible Etiology in Psoriatic Disease

“…Recently, lesion-specific reactivity to HSP subgroups was demonstrated. Guttate type is associated with 14-kDA HSP, 65- and 71-kDA HSP are associated with the plaque form of the disease [13]. De Strooper et al [14] showed in vitro hyper-reactivity of the 68-kDa antigen to the psoriatic keratinocytes.…”