Igg-Dependent Hydrolysis of Myelin Basic Protein of Patients with Different Courses of Schizophrenia

Parshukova, D.; Smirnova, L.; Kornetova, E.; Semke, A.; Buneva, Valentina N.; Ivanova, Svetlana A.

doi:10.1155/2020/8986521

Cited by 10 publications

(21 citation statements)

References 70 publications

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“…25 One study demonstrated that the increased activity of MBPhydrolyzing antibodies is caused by the activation of humoral immunity in schizophrenia. 26 In the present study, the levels of serum IL-1b, IL-6, and MBP were lower in the control group than in the type I and II patient groups. Previous studies have also reported that the levels of serum IL-1b and IL-6 are higher in patients with schizophrenia than in healthy individuals.…”

Section: Discussioncontrasting

confidence: 45%

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Association between CpG island DNA methylation in the promoter region of RELN and positive and negative types of schizophrenia

Zhou

Yan

et al. 2022

J Int Med Res

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Objective To explore the association between CpG island methylation in the promoter region of RELN and positive (type I) and negative (type II) types of schizophrenia, and investigate serum interleukin (IL)-1β, IL-6, and myelin basic protein (MBP) in schizophrenia. Methods Levels of CpG island methylation in the promoter region of RELN were detected in peripheral blood of patients with schizophrenia (experimental group) and healthy individuals (control group), and serum IL-1β, IL-6, and MBP were measured. Results The positive rate of CpG island methylation in the promoter region of RELN was higher in the experimental group than in the control group; however, there were no significant differences between type I and II patients. There were differences in Positive and Negative Syndrome Scale (PANSS) scores and serum IL-1β, IL-6, and MBP between type I and II patients. Furthermore, there were positive correlations between serum IL-1β, IL-6, and MBP and PANSS scores (negative symptoms) in type II patients. Conclusion CpG island methylation in the promoter region of RELN was associated with schizophrenia, but not with its clinical type. There may be different pathological mechanisms in type I and II schizophrenia, and type II schizophrenia may be associated with serum IL-1β, IL-6, and MBP.

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Section: Discussioncontrasting

confidence: 45%

“… 25 One study demonstrated that the increased activity of MBP-hydrolyzing antibodies is caused by the activation of humoral immunity in schizophrenia. 26 …”

Section: Discussionmentioning

confidence: 99%

Association between CpG island DNA methylation in the promoter region of RELN and positive and negative types of schizophrenia

Zhou

Yan

et al. 2022

J Int Med Res

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“…Catalytic antibodies are only a minor part of natural antibodies but significantly enhance the immune system’s functionality ( 55 ). Catalytic antibodies hydrolyzing DNA ( 56 ), RNA and miRNA ( 57 , 58 ), histones ( 59 ), and myelin basic protein (MBP) ( 60 , 61 ) have been described in schizophrenia. Notably, these antigens are DAMPs.…”

Section: Alterations In the Innate Immune System In Schizophreniamentioning

confidence: 99%

Immune System Abnormalities in Schizophrenia: An Integrative View and Translational Perspectives

et al. 2022

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The immune system is generally known to be the primary defense mechanism against pathogens. Any pathological conditions are reflected in anomalies in the immune system parameters. Increasing evidence suggests the involvement of immune dysregulation and neuroinflammation in the pathogenesis of schizophrenia. In this systematic review, we summarized the available evidence of abnormalities in the immune system in schizophrenia. We analyzed impairments in all immune system components and assessed the level of bias in the available evidence. It has been shown that schizophrenia is associated with abnormalities in all immune system components: from innate to adaptive immunity and from humoral to cellular immunity. Abnormalities in the immune organs have also been observed in schizophrenia. Evidence of increased C-reactive protein, dysregulation of cytokines and chemokines, elevated levels of neutrophils and autoantibodies, and microbiota dysregulation in schizophrenia have the lowest risk of bias. Peripheral immune abnormalities contribute to neuroinflammation, which is associated with cognitive and neuroanatomical alterations and contributes to the pathogenesis of schizophrenia. However, signs of severe inflammation are observed in only about 1/3 of patients with schizophrenia. Immunological parameters may help identify subgroups of individuals with signs of inflammation who well respond to anti-inflammatory therapy. Our integrative approach also identified gaps in knowledge about immune abnormalities in schizophrenia, and new horizons for the research are proposed.

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“…Antibodies hydrolyzing myelin basic protein have been found and described in detail in multiple sclerosis (MS) [34], systemic lupus erythematosus (SLE) [35], autism [36], and schizophrenia [37]. We also showed earlier pronounced differences in the level of MBP-hydrolyzing activity of serum antibodies depending on the clinical features of schizophrenia, such as the type of course of the disease, the duration of the disease, and the presence of remission [38]. In addition, the cross-reactivity of antibodies with histone-hydrolyzing and MBP-hydrolyzing activity, as shown in a series of studies [39][40][41][42], indicates a connection between inflammation and damage of the myelin sheath.…”

Section: Introductionmentioning

confidence: 59%

Catalytic Antibodies in Bipolar Disorder: Serum IgGs Hydrolyze Myelin Basic Protein

Parshukova

Smirnova

Vasilieva

et al. 2022

IJMS

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The pathogenesis of bipolar affective disorder is associated with immunological imbalances, a general pro-inflammatory status, neuroinflammation, and impaired white matter integrity. Myelin basic protein (MBP) is one of the major proteins in the myelin sheath of brain oligodendrocytes. For the first time, we have shown that IgGs isolated from sera of bipolar patients can effectively hydrolyze human myelin basic protein (MBP), unlike other test proteins. Several stringent criteria were applied to assign the studied activity to serum IgG. The level of MBP-hydrolyzing activity of IgG from patients with bipolar disorder was statistically significantly 1.6-folds higher than that of healthy individuals. This article presents a detailed characterization of the catalytic properties of MBP-hydrolyzing antibodies in bipolar disorder, including the substrate specificity, inhibitory analysis, pH dependence of hydrolysis, and kinetic parameters of IgG-dependent MBP hydrolysis, providing the heterogeneity of polyclonal MBP-hydrolyzing IgGs and their difference from canonical proteases. The ability of serum IgG to hydrolyze MBP in bipolar disorder may become an additional link between the processes of myelin damage and inflammation.

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Igg-Dependent Hydrolysis of Myelin Basic Protein of Patients with Different Courses of Schizophrenia

Cited by 10 publications

References 70 publications

Association between CpG island DNA methylation in the promoter region of RELN and positive and negative types of schizophrenia

Association between CpG island DNA methylation in the promoter region of RELN and positive and negative types of schizophrenia

Immune System Abnormalities in Schizophrenia: An Integrative View and Translational Perspectives

Catalytic Antibodies in Bipolar Disorder: Serum IgGs Hydrolyze Myelin Basic Protein

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