IgG, IgA and IgM Antibodies against FSH: Serological Markers of Pathogenic Autoimmunity or of Normal Immunoregulation?

Haller, Kadri; Mathieu, C; Rull, Kristiina; Matt, Kadri; Béné, Marie C.; Uibo, Raivo

doi:10.1111/j.1600-0897.2005.00306.x

Cited by 41 publications

(31 citation statements)

References 44 publications

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“…In the field of obstetrics and gynecology, preeclampsia, recurrent miscarriage, endometriosis (25), fibroids (26), several malignant tumors (27), and ovarian diseases such as premature ovarian failure (POF) have been shown to be associated with autoimmunologic processes. Regarding PCOS, studies on autoimmunity yielded conflicting results (17)(18)(19)(20)(28)(29)(30)(31).…”

Section: Discussionmentioning

confidence: 98%

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Serologic markers of autoimmunity in women with polycystic ovary syndrome

Hefler-Frischmuth

Walch

Huebl

et al. 2010

Fertility and Sterility

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Section: Discussionmentioning

confidence: 98%

“…The heterogenous data in PCOS might be related to methodological differences and by the multiplicity of potential immune targets used. These targets comprise various steroidogenic enzymes, gonadotropins and their receptors, the corpus luteum (CL), zona pellucida (ZP), and oocyte (17)(18)(19)(20)(28)(29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

Serologic markers of autoimmunity in women with polycystic ovary syndrome

Hefler-Frischmuth

Walch

Huebl

et al. 2010

Fertility and Sterility

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“…Some studies have shown the presence of anti‐FSH antibodies (IgG, IgM and IgA) on healthy non‐pregnant women and a decrease in IgG and IgM on uncomplicated pregnancy 15 and an increase in those antibodies on infertile women 15, 16. The levels of anti‐FSH IgM antibodies were associated with peripheral FSH levels on patients with tubal and male factor infertility 17.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the immunogenicity of gonadotrophins during controlled ovarian stimulation

Morte¹,

Celma²,

Geyter

et al. 2017

American J Rep Immunol

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ProblemGonadotrophin hormones are used for the controlled ovarian stimulation (COS) as part of the in vitro fertilization techniques. Therapeutic proteins have the potential to induce an unwanted immune response.Method of studyThe presence of anti‐FSH, anti‐LH and anti‐hCG antibodies were determined in patients from two different clinical trials after the repeated administration of hMG or FSH.ResultsIn the first study, 27 subjects were screening for the presence of anti‐FSH antibodies. From the 27 patients, only one patient showed the presence of low levels of antibodies. In a second study, 25 patients were screened for the presence of anti‐FSH, anti‐LH and anti‐hCG antibodies. At the end of the study, no patients showed the presence of antibodies.ConclusionThe results of this study suggest that repeated treatment cycles with FSH or hMG in patients undergoing COS for in vitro fertilization can be safely and effectively applied without concerns for immunogenicity.

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“…Although many hypotheses concerning the pathogenesis of PCOS have been proposed, none fully explain the heterogeneous characteristics of the syndrome [24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Single nucleotide polymorphisms in the TGF-β1 gene are associated with polycystic ovary syndrome susceptibility and characteristics: a study in Korean women

Roh

Yoon

Song

et al. 2016

J Assist Reprod Genet

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Purpose Although many hypotheses regarding the pathogenesis of polycystic ovary syndrome (PCOS) have been generated, genetic studies have not identified specific genes that play a role in PCOS etiopathogenesis. This study aimed to investigate the relationship between TGF-β1 gene polymorphism and PCOS in Koreans. Method A total of 51 Korean women with PCOS and 69 healthy women were enrolled. We analyzed 4 single nucleotide polymorphisms (SNPs) of the TGF-β1 gene (rs11466313, rs1800469, rs2317130, and rs4803457). We also analyzed laboratory measurements, such as free testosterone, glucose, and cholesterol. Results The frequencies of rs1800469T allele negativity, rs4803457T allele negativity, the rs1800469CC genotype, and the rs4803457CC genotype showed positive associations with PCOS (P = 0.003, P = 0.027, P = 0.009, and P=0.031, respectively), whereas the haplotypes rs1800469C-rs4803457T and rs1800469T-rs4803457T showed negative associations with PCOS. A strong protective effect of the Brs1800469CT-rs4803457TT^combination (OR = 0.09) and a strong risk effect of Brs1800469CC-rs4803457CC^(OR = 6.23) for PCOS were observed. The rs1800469C/T and rs2317130C/T SNPs exhibited associations with several laboratory measurements with various levels of significance. Conclusion The results demonstrated an association of TGF-β1 gene polymorphisms with the development and/or characteristics of PCOS in the Korean population.

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IgG, IgA and IgM Antibodies against FSH: Serological Markers of Pathogenic Autoimmunity or of Normal Immunoregulation?

Cited by 41 publications

References 44 publications

Serologic markers of autoimmunity in women with polycystic ovary syndrome

Serologic markers of autoimmunity in women with polycystic ovary syndrome

Assessment of the immunogenicity of gonadotrophins during controlled ovarian stimulation

Single nucleotide polymorphisms in the TGF-β1 gene are associated with polycystic ovary syndrome susceptibility and characteristics: a study in Korean women

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