IgG4‐related sclerosing mastitis in a 49‐year‐old patient with multiple, tumor‐like nodules—Diagnostic accuracy of core needle biopsy

Kriegsmann, Mark; Gomez, Christina; Heil, Jörg; Schäfgen, B; Gutjahr, Ewgenija; Kommoss, Felix K.F.; Kriegsmann, Katharina; Flechtenmacher, Christa; Goeppert, Benjamin; Sinn, Hans‐Peter

doi:10.1111/tbj.13436

Cited by 12 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although ultrasound (US) and mammography of the most commonly used diagnostic techniques for breast diseases have been making continuous progress in techniques, distinguishing the PCM from breast cancer based on the image findings is challenging. 5,9 In recent years, magnetic resonance imaging (MRI) has made some progress in the diagnosis of breast diseases; however, it is too expensive and time consuming to be a routine examination for the diagnosis of PCM in China. 8,10,11 Therefore, contrast-enhanced ultrasound (CEUS) has been tried in the detection of PCM by a few large hospitals in China.…”

Section: Introductionmentioning

confidence: 99%

Combining contrast-enhanced ultrasound and blood cell analysis to improve diagnostic accuracy of plasma cell mastitis

Zheng

Wang

Han

et al. 2021

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Plasma cell mastitis is a benign suppurative disease of the breast, lack of specific clinical manifestations, which is easy to be misdiagnosed and mistreated, often confused with mastitis, breast cancer (BC), and other diseases. Thus, we aimed to establish a combined model of promoting diagnostic accuracy of plasma cell mastitis by contrast-enhanced ultrasound (CEUS) patterns and routine blood cell analysis. Eighty-eight plasma cell mastitis, 91 breast cancer, and 152 other benign breast diseases’ patients grouped according to pathological diagnosis underwent CEUS and blood cell analysis examination; 100 healthy female donors were involved. All the plasma cell mastitis and breast cancer patients presented hyperenhancement of CEUS breast lesions compared with others. The majority of plasma cell mastitis (65/88) showed perfusion defect of CEUS patterns with smooth edge (56/65) and multiple lesions (49/65); in contrast, fewer breast cancer patients (30/91) displayed perfusion defect. White blood cell count (WBC), neutrophils, and neutrophils/lymphocytes ratio of blood cell analysis in plasma cell mastitis patients increased significantly compared with other patients ( P < 0.0001). Combining perfusion defect of CEUS patterns and WBC yielded an area under the receiver operating characteristic curve of 0.831, higher than single 0.720 and 0.774, respectively. The cut-off value of WBC (7.28 × 109/L) helped remaining 65.2% (15/23) atypical cases to be correctly diagnosed as plasma cell mastitis, not misdiagnosed as breast cancer. In conclusion, CEUS presented a clear perfusion defect pattern of plasma cell mastitis lesion for the first time. A precise WBC by routine blood cell analysis test can assist CEUS examination in the differential diagnosis of plasma cell mastitis and breast cancer. It is a promised combination for laboratory diagnostic of PCM.

show abstract

Section: Introductionmentioning

confidence: 99%

Combining contrast-enhanced ultrasound and blood cell analysis to improve diagnostic accuracy of plasma cell mastitis

Zheng

Wang

Han

et al. 2021

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

show abstract

“…Meme tutulumunda MG'de distorsiyon, spiküle lezyon; US'de hipoekoik, posterior akustik gölge oluşturan düzensiz sınırlı solid lezyon, MRG'de morfolojik ve dinamik olarak pseudotumor tablosu oluşturarak maligniteyi taklit eder; radyolojik görüntüleme bulguları non-spesifiktir. Tanı biyopsi ile konulmakta olup histolojide nodüler sklerozan plazma hücreli mastit olarak tanımlanmaktadır [28]. Tedavide steroid etkilidir.…”

Section: İmmünoglobuli̇n G4 Hastaliği İli̇şki̇li̇ Masti̇tunclassified

Radiological Evaluation of Non-infectious Mastitis Outside the Idiopathic Granulomatous

Yılmaz,

Günöz Cömert

2023

trs

View full text Add to dashboard Cite

show abstract

“…Forty-seven cases of lymphocytic infiltrates in the mammary glands related to IgG4-related disease have been reported so far [2,4,[47][48][49][50][51][52][53][54][55][56]. The majority of patients were women presenting with unilateral or bilateral painful mammary pseudotumors, mimicking breast cancer.…”

Section: Igg4-related Breast Diseasementioning

confidence: 99%

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

Goulabchand

Hafidi

Perre

et al. 2020

JCM

View full text Add to dashboard Cite

Mastitis frequently affects women of childbearing age. Of all the pathological breast conditions requiring specific management, autoimmune mastitis is in the third position after infection and breast cancer. The aim of this literature review was to make a comprehensive description of autoimmune diseases targeting the mammary gland. Four main histological patterns of autoimmune mastitis are described: (i) lymphocytic infiltrates; (ii) ductal ectasia; (iii) granulomatous mastitis; and (iv) vasculitis. Our literature search found that all types of autoimmune disease may target the mammary gland: organ-specific diseases (diabetes, thyroiditis); connective tissue diseases (such as systemic erythematosus lupus or Sjögren’s syndrome); vasculitides (granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, giant cell arteritis, polyarteritis nodosa, Behçet’s disease); granulomatous diseases (sarcoidosis, Crohn’s disease); and IgG4-related disease. Cases of breast-specific autoimmune diseases have also been reported, including idiopathic granulomatous mastitis. These breast-limited inflammatory diseases are sometimes the first symptom of a systemic autoimmune disease. Although autoimmune mastitis is rare, it is probably underdiagnosed or misdiagnosed. Early diagnosis may allow us to detect systemic diseases at an earlier stage, which could help to initiate a prompt, appropriate therapeutic strategy. In case of suspected autoimmune mastitis, we hereby propose a diagnostic pathway and discuss the potential pathophysiological pathways leading to autoimmune breast damage.

show abstract

IgG4‐related sclerosing mastitis in a 49‐year‐old patient with multiple, tumor‐like nodules—Diagnostic accuracy of core needle biopsy

Cited by 12 publications

References 9 publications

Combining contrast-enhanced ultrasound and blood cell analysis to improve diagnostic accuracy of plasma cell mastitis

Combining contrast-enhanced ultrasound and blood cell analysis to improve diagnostic accuracy of plasma cell mastitis

Radiological Evaluation of Non-infectious Mastitis Outside the Idiopathic Granulomatous

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

Contact Info

Product

Resources

About