IGRA test for TB in COVID-19: role of corticosteroids

Granozzi, Bianca; Bisognin, Francesco; Tadolini, Marina; Lombardi, Giuseppe; Zangoli, E; Salvi, D.; Dormi, Ada; Monte, Paola Dal

doi:10.5588/ijtld.22.0283

Cited by 3 publications

(34 citation statements)

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“…A definition of indeterminate results was mentioned in 8/12 studies (66.6%). 11,12,[17][18][19][20]25 An indeterminate result was defined according to the manufacturers' definition in six studies, 11,12,17,18,22,25 and as (Nil [baseline] >8.0 IU/mL) or [nil ≤8.0 IU/mL and mitogen-nil <0.5 IU/ mL] in two studies. 19,20 The term "low response to the mitogen" was used in two other studies.…”

Section: Definition Of Indeterminate Results Of Igrasmentioning

confidence: 99%

“…The prevalence of indeterminate QFT-TB results among COVID-19 patients was mentioned in nine studies and varied from 7.14% to 64.58% (Table 2). [10][11][12][18][19][20]22,23,25 For the meta-analysis, the prevalence of indeterminate QFT-TB results was retrieved from eight studies and ranged from 7.14% to 40.33%. 10,12,[18][19][20]22,23,25 We excluded the study of Ward et The overall pooled effect size (equivalent to the pooled proportion of indeterminate QFT-TB Plus results) was 0.26 (95% confidence interval: 0.205−0.324, Τ 2 = 0.158) for QFT-TB Plus.…”

Section: Prevalence Of Indeterminate Quantiferon Results In Covid-19 ...mentioning

confidence: 99%

“…[10][11][12][18][19][20]22,23,25 For the meta-analysis, the prevalence of indeterminate QFT-TB results was retrieved from eight studies and ranged from 7.14% to 40.33%. 10,12,[18][19][20]22,23,25 We excluded the study of Ward et The overall pooled effect size (equivalent to the pooled proportion of indeterminate QFT-TB Plus results) was 0.26 (95% confidence interval: 0.205−0.324, Τ 2 = 0.158) for QFT-TB Plus. The mean of true effect size was 0.26 (95% prediction interval: 0.11−0.5) (Figure 2).…”

Section: Prevalence Of Indeterminate Quantiferon Results In Covid-19 ...mentioning

confidence: 99%

“…COVID-19 patients provided information on the severity of the COVID-19 disease. [10][11][12][18][19][20][22][23][24] QFT-TB indeterminate results in severe COVID-19 reported in four studies, 12,[18][19][20] 12 ), Charlson comorbidity index (Imeneo et al 20 ). -Steroid treatment before QFT testing (Solanich et al 19 ; Granozzi et al 18 ) (the longer the duration of corticosteroid therapy before the QFT testing, the higher the probability of having an indeterminate result [Granozzi et al 18 ]).…”

Section: Clinical Datamentioning

confidence: 99%

“…-High Inflammation-related parameters including LDH (Solanich et al 19 ; Cortes et al 12 ; Granozzi et al 18 ), ferritin (Cortes et al 12 ; Granozzi et al 18 ; Imeneo et al 20 ), CRP (Cortes et al 12 ; Imeneo et al 20 ), D-dimer (Cortes et al 12 ; Imeneo et al 20 ), fibrinogen (Cortes et al 12 ; Imeneo et al 20 ), and IL-6 (Cortes et al 12 ) levels. -Low TNF-alpha level (Imeneo et al 20 ).…”

Section: Laboratory Findingsmentioning

confidence: 99%

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Prevalence of indeterminate tuberculosis interferon‐gamma release assays in COVID‐19 patients: Systematic review and meta‐analysis

Ben Tekaya,

Jerbi,

Ben Sassi

et al. 2023

Health Science Reports

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Background and AimsThe reliability of interferon‐gamma‐release‐assays (IGRAs) for tuberculosis (TB) testing in coronavirus disease 2019 (COVID‐19) patients is unknown. This study aimed to systematically review the prevalence of indeterminate TB‐IGRA following SARS‐CoV‐2 infection or vaccination and to review associated factors.MethodsThis systematic literature review was guided according to the PRISMA guidelines by searching PubMed, Scopus, Web of Science, Clinicalkey, and Cochrane Library. Studies reporting results of TB‐IGRA tests (QuantiFERON [QFT]‐TB, T‐SPOT.TB) in COVID‐19 patients or vaccines were included. The random effects model was used to assess the prevalence of indeterminate IGRA results. Heterogeneity was evaluated using the Τ2 and 95% predictive interval.ResultsOf the 273 citations screened, 12 articles were included in the final analysis including a total of 2107 patients. The overall pooled effect size proportion of indeterminate QFT‐TB results, estimated in eight studies using the QFT‐TB Plus assay, was 0.26 (95% CI: 0.205−0.324, Τ2 = 0.158). The mean true effect size was 0.26 (95% predictive interval: [0.110−0.500]). A subgroup analysis was not undertaken due to the small number of studies. Indeterminate QFT‐TB rates were associated with COVID‐19 severity, steroid treatment, inflammation‐related parameters, neutrophilia, and lymphopenia.ConclusionIndeterminate QFT‐TB results in COVID‐19 patients occur in almost one‐quarter of tests performed. Further studies are needed to assess associated factors.

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