IGSF1: A novel oncogene regulates the thyroid cancer progression

Abstract

Thyroid cancer has been continuously increasing and extraordinarily prevalent worldwide. The genetic diagnosis has been widely used in fine needle aspiration. IGSF1, an immunoglobulin superfamily member 1, has been shown to be associated with the regulation of thyroid hormone. But the function of IGSF1 in thyroid cancer has not been explored yet. In this article, we will illuminate the correlation between IGSF1 expression and thyroid cancer. We analysed the level of IGSF1 expression in 55 pairs of tissue samples by real‐time polymerase chain reaction (PCR) and The Cancer Genome Atlas (TCGA) data portal. After that, we transfected small interfering RNA to silence IGSF1 in thyroid cancer cell lines (KTC‐1 and BCPAP) and confirmed the function of IGSF1 by performed colony formation, migration, invasion, cell counting kit‐8, and apoptosis assays. IGSF1 was upregulated in thyroid cancer tissues compared with the adjacent normal tissues (t = 5.783, df = 54; P < .0001) and TCGA (T: N = 65.91 ± 3.998, n = 501: 2.824 ± 0.273, n = 58; P < .0001). In thyroid cell lines, experiments showed that downregulated IGSF1 inhibited proliferation, metastasis, and promoted cell apoptosis. Meanwhile, inhibited IGSF1 expression could downregulate N‐cadherin, vimentin, and EZH2, which is associated with metastasis. Thyroid cancer cells IGSF1 expression levels are a correlation with its ability to growth, metastasis, and apoptosis.

Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis

“…Some of the genes have also been associated with development of specific tumors, e.g. TAC4 [ 5 ], IGSF1 [ 17 ] and SLC39A8 (ZIP8) [ 24 ]. A prognostic role has also been reported for some of these genes, both negative ( ERRFI1 ) [ 25 ], and positive ( SLC44A3 ) [ 29 ].…”

Immune-Related Gene-Based Novel Subtypes to Establish a Model Predicting the Risk of Prostate Cancer

“…They proposed that surgical excision of malignant tissue in PCa caused a decrease in oxidative stress and that a higher level of PON3 was associated with lower oxidative stress (Bedİr et al, 2020). Finally, IGSF1 is a novel oncogene regulating the progression of thyroid cancer (Guan et al, 2019); however, no study describing its role in PCa has been reported. The predictive model established here showed good ability to predict DFS or BCR in TCGA, GSE116918, DKFZ2018, MSKCC2010, and ICGC-PRAD-FR datasets.…”

Overview of current targeted therapy in gallbladder cancer

“…[330][331][332][333] Typical therapeutic blocking agents employed to target KIT include cabozantinib, dovitinib, masitinib, and pazopanib. [334][335][336] At present, two additional clinical trials (NCT01153750, NCT02115542) wait for final results.…”