2008
DOI: 10.1002/ppul.20793
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IL‐10 gene polymorphism at −1082 A/G is associated with severe rhinovirus bronchiolitis in infants

Abstract: We analyzed polymorphisms of IL-10 -1082 G/A, IL-18 -137 G/C, TLR4 +896 A/G, and IFNG +874 T/A in 139 infants under 6 months of age hospitalized with bronchiolitis and 400 unselected blood donors. Causative viruses were determined by PCR. Infants with bronchiolitis associated with a virus other than respiratory syncytial virus (N = 18), were more often IL-10 -1082 allele G non-carriers, that is, homozygous for allele A (AA) than controls (66.7% vs. 28.0%, P < 0.0001). Infants with RSV bronchiolitis did not dif… Show more

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Cited by 67 publications
(100 citation statements)
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“…Several studies focused on the role of genetic variation in the IL10 gene locus in the pathophysiology of acute RSV LRTI. Overall, the frequency of IL10 polymorphisms in infants with RSV LRTI did not differ from controls (22)(23)(24)(25). However, in infants hospitalized Յ6 mo of age, the IL10 -592C allele was related to RSV LRTI hospitalization (23).…”
Section: Discussionmentioning
confidence: 91%
“…Several studies focused on the role of genetic variation in the IL10 gene locus in the pathophysiology of acute RSV LRTI. Overall, the frequency of IL10 polymorphisms in infants with RSV LRTI did not differ from controls (22)(23)(24)(25). However, in infants hospitalized Յ6 mo of age, the IL10 -592C allele was related to RSV LRTI hospitalization (23).…”
Section: Discussionmentioning
confidence: 91%
“…We prospectively followed up a group of children hospitalised for bronchiolitis at ,6 months of age in 2001-2002 and 2002-2004 [15,16]. RSV was the causative agent in 70%, rhinovirus in 7% and other viruses in 7% of the cases [15].…”
mentioning
confidence: 99%
“…RSV was the causative agent in 70%, rhinovirus in 7% and other viruses in 7% of the cases [15]. When the children were 5-6 yrs of age, they were invited to a clinical follow-up study in [2008][2009].…”
mentioning
confidence: 99%
“…(28,29) The higher morbidity of the children with a moderate to severe respiratory condition can be partially explained by the more intense activity of the inflammatory cascade in some individuals, with an increase in the damage to the respiratory epithelium already damaged by RSV activity, and by the presence of coinfection with other etiologic agents at hospital admission. Despite this, there were no deaths in our sample, partly due to the absence of specific risk factors for severe disease caused by RSV, such as bronchopulmonary dysplasia and congenital heart disease, and also due to the fact that most of our patients were born at term.…”
Section: Discussionmentioning
confidence: 99%