IL-10 high producing genotype predisposes HIV infected individuals to TB infection

Sunder, Sharada Ramaseri; Hanumanth, Surekha Rani; Nagaraju, Raghavendar T.; Venkata, Sanjeev Kumar Neela; Suryadevara, Naveen Chandra; Pydi, Satya Sudheer; Gaddam, Sumanlatha; Jonnalagada, Subbanna; Valluri, Vijaya Lakshmi

doi:10.1016/j.humimm.2012.03.012

Cited by 27 publications

(6 citation statements)

References 41 publications

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“…There are 29 case-control studies concerning -1082G/A polymorphism [16]–[44], 14 case-control studies concerning -819T/C polymorphism [16], [18], [20]–[23], [25], [31], [33], [37]–[39], [42], [45], and 16 case-control studies concerning -592A/C polymorphism [16], [20]–[25], [28], [31], [33], [37]–[40], [45], [46]. Among the 31 eligible studies, 17 of them were of Asians [16], [18], [19], [26], [28], [30]–[32], [34], [36], [39], [41]–[44], [46], 6 studies were of Europeans [17], [21], [25], [27], [35], [37], 5 studies were of Africans [20], [22], [29], [33], [38], and 3 studies were of Americans [23], [24], [40]. Controls were selected from healthy population in all studies and most studies used frequency-matched controls to the cases by age, sex, or ethnicity.…”

Section: Resultsmentioning

confidence: 99%

Association between IL-10 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence Based on a Meta-Analysis

Liang

Guo

et al. 2014

PLoS ONE

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BackgroundA number of observational studies have been conducted to investigate the association of IL-10 gene polymorphisms with tuberculosis (TB) susceptibility. However, the results of different studies were inconsistent. The aim of this study was to investigate the relationship between IL-10 -1082G/A, -819T/C, and -592A/C polymorphisms and TB risk by meta-analysis.MethodsA literature search was conducted among six English databases (PubMed, Embase, Web of Science, Science Direct, SpringerLink and EBSCO) and two Chinese databases (Wanfang and Chinese National Knowledge Infrastructure databases) to identify studies involving association between IL-10 −1082G/A, −819T/C, and −592A/C polymorphisms and TB susceptibility before May. 2013. Statistical analysis was performed using Revman 5.0 and Stata 12.0.ResultsA total of 31 studies with 6,559 cases and 7,768 controls were included in this meta-analysis. The results showed that three polymorphisms (-1082G/A, -819T/C, and -592A/C) in the IL-10 gene were not associated with the risk of TB in general population. In the subgroup analysis by ethnicity, IL-10 -1082G/A polymorphism was associated with TB risk in Europeans (AA+AG vs. GG: OR = 0.57, 95% CI = 0. 0.37–0.89, P = 0.01) and Americans (AA+AG vs. GG: OR = 0.39, 95% CI = 0.27–0.57, P<0.01), and IL-10 -819T/C (C allele vs. T allele: OR = 0.83, 95% CI = 0.72–0.96, P = 0.01) and -592A/C (CC+AC vs. AA: OR = 0.65, 95% CI = 0.49–0.85, P = 0.002) polymorphisms were significantly associated with TB risk in Asians.ConclusionThis meta-analysis provides strong evidence that IL-10-1082G/A polymorphism was associated with TB risk in Europeans and Americans, and IL-10 -819T/C and -592A/C polymorphisms could be risk factors for TB in Asians. Additional well designed large studies were required for the validation of our results.

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Section: Resultsmentioning

confidence: 99%

Association between IL-10 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence Based on a Meta-Analysis

Liang

Guo

et al. 2014

PLoS ONE

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“…Two of the selected studies in our meta-analysis considered the impact of HIV status on susceptibility to TB [ 14 , 31 ]. However, many researchers have focused on this issue.…”

Section: Discussionmentioning

confidence: 99%

“…An increasing number of studies have begun to investigate the mechanism of how HIV infection influences susceptibility to TB. It was reported that antigens such as HLA-A31 and HLA-B41, chemokine receptors such as CCR5, and the -1082G allele of IL-10 were involved in TB susceptibility [ 31 , 62 – 63 ]. However, the exact mechanism remains unclear, and additional studies are needed to clarify this issue.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Tuberculosis: A Meta-Analysis

et al. 2015

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ObjectiveAs an update to other recent meta-analyses, the purpose of this study was to explore whether interleukin-10 (IL-10) polymorphisms and their haplotypes contribute to tuberculosis (TB) susceptibility.MethodsWe searched for published case-control studies examining IL-10 polymorphisms and TB in PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Wanfang databases and the Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strengths of the associations.ResultsA total of 28 studies comprising 8,242 TB patients and 9,666 controls were included in the present study. There were no significant associations between the -1082G/A, -819C/T, and -592A/C polymorphisms and TB in the pooled samples. Subgroup analyses revealed that the -819T allele was associated with an increased TB risk in Asians in all genetic models (T vs. C: OR=1.17, 95% CI=1.05-1.29, P=0.003; TT vs. CC: OR=1.37, 95% CI=1.09-1.72, P=0.006; CT+TT vs. CC: OR=1.33, 95% CI=1.09-1.63, P=0.006; TT vs. CT+CC: OR=1.17, 95% CI=1.02-1.35, P=0.03) and that the -592A/C polymorphism was significantly associated with TB in Europeans under two genetic models (A vs. C: OR=0.77, 95% CI=0.60-0.98, P=0.03; AA vs. CC: OR=0.53, 95% CI=0.30-0.95, P=0.03). Furthermore, the GCC IL-10 promoter haplotype was associated with an increased risk of TB (GCC vs. others: P=1.42, 95% CI=1.02-1.97, P=0.04). Subgroup analyses based on ethnicity revealed that the GCC haplotype was associated with a higher risk of TB in Europeans, whereas the ACC haplotype was associated with a lower TB risk in both Asians and Europeans.ConclusionsThis meta-analysis suggests that the IL-10-819T/C polymorphism is associated with the risk of TB in Asians and that the IL-10-592A/C polymorphism may be a risk factor for TB in Europeans. Furthermore, these data indicate that IL-10 promoter haplotypes play a vital role in the susceptibility to or protection against the development of TB.

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“…In people, established helminth infection also imposes an IL‐10‐dominated response to malarial antigens . IL‐10 expression is also implicated in HIV and tuberculosis co‐infection, and genetic polymorphisms that predispose to exaggerated IL‐10 production correlate with higher rates of co‐infection . Such cytokine cross‐talk can, however, be exploited for clinical benefit.…”

Section: The Impact Of Immune Regulationmentioning

confidence: 99%

Protection and pathology during parasite infection: IL‐10 strikes the balance

Redpath

Fonseca

Perona-Wright

2014

Parasite Immunology

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SUMMARYThe host response to infection requires an immune response to be strong enough to control the pathogen but also restrained, to minimize immune-mediated pathology. The conflicting pressures of immune activation and immune suppression are particularly apparent in parasite infections, where co-evolution of host and pathogen has selected many different compromises between protection and pathology. Cytokine signals are critical determinants of both protective immunity and immunopathology, and, in this review, we focus on the regulatory cytokine IL-10 and its role in protozoan and helminth infections. We discuss the sources and targets of IL-10 during parasite infection, the signals that initiate and reinforce its action, and its impact on the invading parasite, on the host tissue, and on coincident immune responses.

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IL-10 high producing genotype predisposes HIV infected individuals to TB infection

Cited by 27 publications

References 41 publications

Association between IL-10 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence Based on a Meta-Analysis

Association between IL-10 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence Based on a Meta-Analysis

Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Tuberculosis: A Meta-Analysis

Protection and pathology during parasite infection: IL‐10 strikes the balance

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