IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to IL-6, TNF-α, TGF-β1 and blood–brain barrier function

Csuka, Esther; Morganti-Kossmann, Maria Cristina; Lenzlinger, Philipp M.; Joller, Helen; Trentz, O.; Kossmann, Thomas

doi:10.1016/s0165-5728(99)00148-4

Cited by 304 publications

(234 citation statements)

References 49 publications

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“…[40][41][42] Its neuroprotective characteristics include suppression of microglia and astroglia activation, as well as decreased production of proinflammatory cytokines 43,44 and reactive oxygen species. 45 Thus, it has been proposed that IL-10 treatment improves outcome in neuropathology. Indeed, after TBI in rats, systemic administration of IL-10 improved neurological recovery 43 and significantly attenuated the expression of proinflammatory cytokines including IL-1 in the injured hippocampus.…”

Section: Interleukin-10mentioning

confidence: 99%

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Involvement of Pro- and Anti-Inflammatory Cytokines and Chemokines in the Pathophysiology of Traumatic Brain Injury

2010

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Summary:Despite dramatic improvements in the management of traumatic brain injury (TBI), to date there is no effective treatment available to patients, and morbidity and mortality remain high. The damage to the brain occurs in two phases, the initial primary phase being the injury itself, which is irreversible and amenable only to preventive measures to minimize the extent of damage, followed by an ongoing secondary phase, which begins at the time of injury and continues in the ensuing days to weeks. This delayed phase leads to a variety of physiological, cellular, and molecular responses aimed at restoring the homeostasis of the damaged tissue, which, if not controlled, will lead to secondary insults. The development of secondary brain injury represents a window of opportunity in which pharmaceutical compounds with neuroprotective properties could be administered. To establish effective treatments for TBI victims, it is imperative that the complex molecular cascades contributing to secondary injury be fully elucidated. One pathway known to be activated in response to TBI is cellular and humoral inflammation. Neuroinflammation within the injured brain has long been considered to intensify the damage sustained following TBI. However, the accumulated findings from years of clinical and experimental research support the notion that the action of inflammation may differ in the acute and delayed phase after TBI, and that maintaining limited inflammation is essential for repair. This review addresses the role of several cytokines and chemokines following focal and diffuse TBI, as well as the controversies around the use of therapeutic anti-inflammatory treatments versus genetic deletion of cytokine expression.

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Section: Interleukin-10mentioning

confidence: 99%

“…47 Increased production of IL-10 in human CSF of adult TBI patients corresponded to decreases in tumor necrosis factor levels; however, no correlation was found between IL-10 and outcome. 45 …”

Section: Interleukin-10mentioning

confidence: 99%

Involvement of Pro- and Anti-Inflammatory Cytokines and Chemokines in the Pathophysiology of Traumatic Brain Injury

2010

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“…This rise in CSF IL-10 is associated with a corresponding decrease in TNF-␣ levels, consistent with its anti-inflammatory function. 62 Increase in IL-10 levels has been shown to correlate with mortality in pediatric TBI. 63 TGF-␤ is a member of a large super family of growth factors that are important for a number of biological functions including cell growth and differentiation, angiogenesis, immune function, extracellular matrix production, cell chemotaxis, and apoptosis.…”

Section: Anti-inflammatory Cytokinesmentioning

confidence: 99%

Biomarkers for the Diagnosis, Prognosis, and Evaluation of Treatment Efficacy for Traumatic Brain Injury

et al. 2010

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“…These 138 tissue specific biomarkers (discussed in greater detail below) hold great promise as they are typically 139 released into the CSF then taken up into the blood stream, allowing for their detection local to the 140 injury site and systemically. The quantity of these proteins in the CSF and blood might directly relate 141 to the extent of neuronal or glial damage that has occurred following SCI (12,13). …”

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confidence: 99%

The developing landscape of diagnostic and prognostic biomarkers for spinal cord injury in cerebrospinal fluid and blood

Fuller

et al. 2016

Spinal Cord

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IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to IL-6, TNF-α, TGF-β1 and blood–brain barrier function

Cited by 304 publications

References 49 publications

Involvement of Pro- and Anti-Inflammatory Cytokines and Chemokines in the Pathophysiology of Traumatic Brain Injury

Involvement of Pro- and Anti-Inflammatory Cytokines and Chemokines in the Pathophysiology of Traumatic Brain Injury

Biomarkers for the Diagnosis, Prognosis, and Evaluation of Treatment Efficacy for Traumatic Brain Injury

The developing landscape of diagnostic and prognostic biomarkers for spinal cord injury in cerebrospinal fluid and blood

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