IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis

Li, Z.; Liu, Y.; Cao, Deliang; Jiang, Ming; Luo, Fan

doi:10.4238/2015.june.26.10

Cited by 11 publications

(7 citation statements)

References 21 publications

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“…Another three case-control studies in Chinese populations reported that the IL-17 rs2275913 A allele was associated with increased risk for the development of gastric cancer (Qinghai et al, 2014;Wang et al, 2014;Hou and Yang, 2015). However, one case-control study and one meta-analysis study reported inconsistent results with the previously mentioned studies (Kutikhin et al, 2014;Li et al, 2015c), and several other studies demonstrated that the IL-17 rs2275913 genetic variation did not affect susceptibility to gastric cancer (Kutikhin et al, 2014;Li et al, 2015c). In the present study, we found that the AA genotype and the A allele of the IL-17 rs2275913 SNP appeared to be associated with a higher risk of developing gastric cancer.…”

Section: Discussioncontrasting

confidence: 35%

IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population

Dong

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The purpose of this hospital-based case-control study was to assess whether the interleukin (IL)-17 rs2275913 genetic variation can influence susceptibility to gastric cancer. Samples from a total of 202 gastric cancer patients and 237 controls were collected from the Linyi People's Hospital between March 2013 and March 2015. The IL-17 rs2275913 gene polymorphism was identified by polymerase chain reaction and restriction fragment length polymorphism. When compared with control subjects, gastric cancer patients were older in age (OR = 3.89, 95%CI = 2.55-5.95), male (OR = 2.08, 95%CI = 1.39-3.10), had a habit of alcohol consumption (OR = 1.71, 95%CI = 1.15-2.55), and were more likely to be infected with Helicobacter pylori (OR = 2.76, 95%CI = 1.83-4.16). We observed that the AA genotype of the IL-17 rs2275913 polymorphism resulted in a 2.32-fold risk of gastric cancer compared to the GG genotype (OR = 2.32, 95%CI = 1.20-4.54; P = 0.01). The AG combined with AA genotype of the IL-17 rs2275913 polymorphism had more risk of developing gastric cancer than the GG genotype (OR = 1.50, 95%CI = 1.01-2.23; P = 0.04). Moreover, the AA genotype of the IL-17 rs2275913 polymorphism was correlated with a higher risk of developing gastric cancer than the GG and AG genotypes combined (OR = 2.01, 95%CI = 1.08-3.79; P = 0.02). In conclusion, the results of our study suggest that the IL-17 rs2275913 polymorphism could contribute to the risk of gastric cancer.

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Section: Discussioncontrasting

confidence: 35%

IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population

Dong

et al. 2016

Genet. Mol. Res.

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“…The human IL-17A gene is located on chromosome 6p12.1 [ 34 ]. The a allele of rs2275913 in the promoter region of the IL-17 gene has been reported to be associated with risk of ulcerative colitis [ 35 ], gastric cancer [ 36 ] and atopic dermatitis [ 17 ]. The a allele of rs2275913 enhances IL-17A promoter activity and promotes its transcription, leading to enhanced inflammation in the airway [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Association of interleukin-17a rs2275913 gene polymorphism and asthma risk: a meta-analysis

Zhai¹,

Li²,

Feng³

et al. 2018

aoms

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IntroductionInterleukin-17A (IL-17A), a pro-inflammatory cytokine, plays an important role in the pathogenesis of asthma. A number of studies have investigated the relationship between IL-17A rs2275913 polymorphism and risk of asthma. However, the results obtained are inconclusive. The aim of this meta-analysis is to clarify the relationship between IL-17A rs2275913 polymorphism and asthma risk.Material and methodsSearches were conducted in PubMed, Web of Science, Elsevier, Google Scholar, Wanfang and Chinese National Knowledge Infrastructure (CNKI) databases, and data were extracted from eligible studies by two independent reviewers. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated. Publication bias, heterogeneity and sensitivity analysis were also assessed.ResultsTen studies with a total of 5016 subjects were included. Overall, the results indicated a significant association between the IL-17A rs2275913 polymorphism and the risk of asthma (G vs. A: OR = 0.866, 95% CI: 0.789–0.951, p = 0.003; GG+GA vs. AA: OR = 0.752, 95% CI: 0.633–0.895, p = 0.001). In subgroup analysis by age and ethnicity, the G allele of rs2275913 in IL-17A was significantly associated with a reduced risk of asthma in children and Asians.ConclusionsThe results of this meta-analysis indicate that the G allele of rs2275913 in IL-17A is a protective factor for the development of asthma.

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“…Recently, much attention has focused on the action of the IL-17/IL-23 axis, which is believed to be a major player in inflammation-related malignancies, such as gastric neoplasms9101112131415162223. Indeed, epidemiological analyses revealed that Asian patients with selected polymorphisms in genes coding for both IL-17 and IL-23 may have an altered risk for developing gastric cancer242526272829. However, very little is known at present about the clinical significance of IL-17 and IL-23 in the pathogenesis of different types of gastric neoplasms in humans.…”

Section: Discussionmentioning

confidence: 99%

Interleukins 17 and 23 in patients with gastric neoplasms

Błogowski

Madej-Michniewicz

Marczuk

et al. 2016

Sci Rep

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Recently there has been heightened interest in the potential significance of interleukin (IL)-17 and IL-23 in the development/progression of human malignancies. Here, we analyzed the systemic levels of these cytokines in 75 patients with different types of gastric neoplasms (carcinoma, gastrointestinal stromal tumors, neuroendocrine neoplasms, and lymphomas) and 42 healthy volunteers. We found that patients with all types of gastric neoplasms have significantly lower IL-23 levels. However, in comparison to the levels in healthy individuals, IL-17 concentrations were lower only in patients with types of gastric neoplasms other than carcinoma. Interestingly, IL-17 levels significantly differed between patients with early and advanced gastric carcinoma. No significant associations were detected between the systemic levels of examined interleukins and TNM staging. However, peripheral levels of IL-23 were correlated with the absolute numbers of circulating populations of bone marrow-derived mesenchymal and very small embryonic/epiblast-like stem cells in patients with gastric carcinoma. ROC curve analyses demonstrated that systemic levels of IL-17 seem to meet basic criteria for consideration as a helpful diagnostic marker in the detection of gastric carcinoma. In conclusion, our study provides translational evidence confirming the clinical significance of IL-17 and IL-23 in the pathogenesis of different types of gastric neoplasms in humans.

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IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis

Cited by 11 publications

References 21 publications

IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population

IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population

Association of interleukin-17a rs2275913 gene polymorphism and asthma risk: a meta-analysis

Interleukins 17 and 23 in patients with gastric neoplasms

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