IL-18: a suggested target for immunomodulation in chikungunya virus infection

Chirathaworn, Chintana; Chansaenroj, Jira; Pongsuchart, Pornsuri; Poovorawan, Yong

doi:10.1007/s00705-020-04849-3

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…We found IL-10 and TNF levels were augmented, followed by a sustained increase in CCL2 levels in the footpad in either AnxA1 KO or WT (BALB/c) animals compared with their respective uninfected controls ( Figure 3 D–F). Augmented TNF has been implicated in CHIKV-induced chronic arthritis and related to the persistence of pain [ 40 ]. Moreover, CCL2 is involved in cellular infiltration during CHIKV infection [ 6 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

Annexin A1-FPR2/ALX Signaling Axis Regulates Acute Inflammation during Chikungunya Virus Infection

Araújo

Costa

Santos

et al. 2022

Cells

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Chikungunya (CHIKV) is an arthritogenic alphavirus that causes a self-limiting disease usually accompanied by joint pain and/or polyarthralgia with disabling characteristics. Immune responses developed during the acute phase of CHIKV infection determine the rate of disease progression and resolution. Annexin A1 (AnxA1) is involved in both initiating inflammation and preventing over-response, being essential for a balanced end of inflammation. In this study, we investigated the role of the AnxA1-FPR2/ALX pathway during CHIKV infection. Genetic deletion of AnxA1 or its receptor enhanced inflammatory responses driven by CHIKV. These knockout mice showed increased neutrophil accumulation and augmented tissue damage at the site of infection compared with control mice. Conversely, treatment of wild-type animals with the AnxA1 mimetic peptide (Ac2–26) reduced neutrophil accumulation, decreased local concentration of inflammatory mediators and diminished mechanical hypernociception and paw edema induced by CHIKV-infection. Alterations in viral load were mild both in genetic deletion or with treatment. Combined, our data suggest that the AnxA1-FPR2/ALX pathway is a potential therapeutic strategy to control CHIKV-induced acute inflammation and polyarthralgia.

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Section: Resultsmentioning

confidence: 99%

Annexin A1-FPR2/ALX Signaling Axis Regulates Acute Inflammation during Chikungunya Virus Infection

Araújo

Costa

Santos

et al. 2022

Cells

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“…However, in 2018, a largescale outbreak occurred in different parts of Thailand. Although the clinical manifestations and cytokine profiles of CHIKV infection have been reported [10][11][12][13], no study has investigated the rheumatic manifestations associated with infection by this virus. The objectives of our study were to describe the rheumatic manifestations of CHIKV infection, estimate the prevalence of enthesitis in CHIKV-infected patients, and determine the factors associated with the presence of CHIKV infection-induced enthesitis.…”

Section: Introductionmentioning

confidence: 99%

Rheumatic manifestations of Chikungunya virus infection: Prevalence, patterns, and enthesitis

et al. 2021

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Chikungunya virus (CHIKV) is an arthropod-borne virus transmitted by mosquitoes of the genus Aedes. CHIKV infection causes various rheumatic symptoms, including enthesitis; however, these effects are rarely investigated. The aim of this study was to describe the rheumatic manifestations in CHIKV infection, estimate the prevalence of enthesitis in CHIKV-infected patients, and determine the factors associated with CHIKV-induced enthesitis. We conducted a prospective, observational study in patients with CHIKV infection confirmed by positive RT-PCR or IgM assay from October 2019 to March 2020. Patients with pre-existing inflammatory rheumatic diseases were excluded. A rheumatologist evaluated the demographic and clinical characteristics of the patients, including the number of inflamed joints, enthesitis sites, tendinitis, and tenosynovitis. The Leeds enthesitis index (LEI) and the Maastricht ankylosing spondylitis enthesis score (MASES) were used to evaluate enthesitis sites. Factors associated with enthesitis were determined using logistic regression analysis. One hundred and sixty-four participants diagnosed with CHIKV infection were enrolled. The mean (SD) age of the patients was 48.2 (14) years. The most common pattern of rheumatic manifestations was polyarthritis with or without enthesitis. Enthesitis was observed in 63 patients (38.4%). The most common site of enthesitis was the left lateral epicondyle as assessed by LEI and the posterior superior iliac spine as assessed by MASES. Multivariate analysis indicated that the number of actively inflamed joints and Thai-HAQ score at the initial evaluation were significantly associated with the presence of enthesitis. The main rheumatic manifestations of CHIKV infection were arthritis/arthralgia, with enthesitis as a prominent extraarticular feature. CHIKV infection can cause enthesitis at peripheral and axial sites. We found that enthesitis was associated with a high number of inflamed joints and reduced physical function. These results indicate that the assessment of enthesitis should be considered when monitoring disease activity and as a treatment response parameter in CHIKV-infected patients.

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Elevated Complement Activation Fragments and C1q-Binding Circulating Immune Complexes in Varied Phases of Chikungunya Virus Infection

Kasbe,

Tripathy,

Wani

et al. 2024

Curr Microbiol

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IL-18: a suggested target for immunomodulation in chikungunya virus infection

Cited by 4 publications

References 25 publications

Annexin A1-FPR2/ALX Signaling Axis Regulates Acute Inflammation during Chikungunya Virus Infection

Annexin A1-FPR2/ALX Signaling Axis Regulates Acute Inflammation during Chikungunya Virus Infection

Rheumatic manifestations of Chikungunya virus infection: Prevalence, patterns, and enthesitis

Elevated Complement Activation Fragments and C1q-Binding Circulating Immune Complexes in Varied Phases of Chikungunya Virus Infection

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