IL-18 polymorphisms and tuberculosis susceptibility: a meta-analysis

Abstract

Objective To investigate the association between IL-18 polymorphisms and Tuberculosis(TB). Materials and methods We searched PubMed and Embase databases, and conducted a meta-analysis using 4 models. Data were extracted from the studies by two independent reviewers. Statistical analysis was performed using STATA 12.0 software. Results Five qualified studies with a total of 1293 TB patients and 1724 controls were included. There was no significant association between the IL-18 -607C>A polymorphism and TB risk in the total population(AA vs CC: OR=1.27,95% CI=0.82–1.96;-CA vs CC:OR=1.06,95% CI=0.89–1.26; Dominant model: OR =1.09, 95% CI =0.83–1.43; Recessive model:OR=1.23, 95% CI=0.92–1.65). For IL-18 -137G>C polymorphism, lack of an association was also found(GG vs CC: OR=1.42,95% CI=0.78–2.58;GC vs CC:OR=1.16,95% CI=0.62–2.16; Dominant model: OR =1.34,95% CI=0.74–2.43;Recessive model:OR=0.96,95%-CI=0.26–3.56). Conclusion The present meta-analysis found no evidence for IL-18 -607C>A and -137G>C polymorphisms as risk factors for TB. Further large-scale and well-designed articles are still needed to validate this result.

Interleukin-18 and interferon-γ single nucleotide polymorphisms in Egyptian patients with tuberculosis

“…There is growing evidence suggesting an important role for inflammatory cytokines in the pathogenesis of TB [ 19 , 20 ]. The presence of genotypic variations in different cytokines is known to be associated with increased susceptibility to TB infection [ 11 , 21 ] and hence, recognizing the genetic factors influencing TB has increasingly attracted interest. A relation may occur when the polymorphism itself is functional and leads to altered susceptibility to the disease, or when an allele SNP is in LDS with an allele which is associate with disease susceptibility, or because of a conflicting effect induced by population.…”

“…This is partially consistent with previous studies reporting the lack of significant association between SNP at the Il-18-607 position and TB susceptibility [ 27 , 28 ]. Furthermore, Zhen et al [ 11 ] conducted a meta-analysis of five case-control studies, involving 1293 TB cases and 1724 healthy subjects for the IL-18 -607C/A polymorphism and found no association between this variant and TB susceptibility.…”

“…Two of the most common single nucleotide polymorphisms in IL-18 gene are located in the promoter region: -607C/A (rs1946518) and -137G/. C (rs187238) [ 10 , 11 ]. Cloning and transcriptional research revealed that IL-18 expression was modified with these two polymorphisms.…”

“…Cloning and transcriptional research revealed that IL-18 expression was modified with these two polymorphisms. Nevertheless, studies done to investigate possible contribution of IL-18 polymorphisms to TB susceptibility have produced conflicting findings [ 11 ].…”

Infections, NCDS, and the scourge of cyclones and Ebola in sub-Saharan Africa

“…Meanwhile we continue struggling with a huge burden of endemic infectious diseases with worrying non-communicable diseases, especially cancer and diabetes mellitus. Thus, we have papers on TB susceptibility2, sputum collection for TB diagnosis in Burkina Faso3, and a review of long neglected diseases such as leishmaniasis4, schistosomiasis5 and Hymenolesis nana 6. While Ugandan authors7 bring us to speed on bednets, a Tunisian group, have an interesting treatise on resistance to temephos8 and organophosphate9 by Culex pipiens pipiens mosquitoes.…”