IL-22 deficiency increases CD4 T cell responses to mucosal immunization

Budda, Scott A; Zenewicz, Lauren A.

doi:10.1016/j.vaccine.2018.05.011

Cited by 4 publications

(5 citation statements)

References 38 publications

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“…It is suggested that IL-22 may persuade resistance against HIV infection in people who are exposed to virus several times by enhancing mucus production (74). As IL-22 enhances and maintains mucosal barrier integrity, its transient inhibition is also suggested for mucosal vaccines to increase T cell response (75).…”

Section: Mucus Productionmentioning

confidence: 99%

A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration

et al. 2020

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Wound healing and tissue regeneration is an intricate biological process that involves repair of cellular damage and maintenance of tissue integrity. Cascades involved in wound healing and tissue regeneration highly overlap with cancer causing pathways. Usually, subsequent tissue damage events include release of a number of cytokines to accomplish post-trauma restoration. IL-22 is one of the cytokines that are immediately produced to initiate immune response against several tissue impairments. IL-22 is a fundamental mediator in inflammation, mucous production, protective role against pathogens, wound healing, and tissue regeneration. However, accumulating evidence suggests pivotal role of IL-22 in instigation of various cancers due to its pro-inflammatory and tissue repairing activity. In this review, we summarize how healing effects of IL-22, when executed in an uncontrollable fashion can lead to carcinogenesis.

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Section: Mucus Productionmentioning

confidence: 99%

A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration

et al. 2020

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“…Inclusion of IL-22 for evaluation of mucosal vaccines may aid in their development. In contrast, neutralizing or limiting IL-22 responses at the time of mucosal vaccination may enhance the generation of T cell responses through increased barrier permeability and enhanced Ag presentation (92). Thus, the gap in knowledge regarding IL-22 biology in vaccine development is an area of potential high rewards for current and future investigations.…”

Section: Is Il-22 Relevant To Vaccinology?mentioning

confidence: 99%

IL-22: There Is a Gap in Our Knowledge

Zenewicz

2018

ImmunoHorizons

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IL-22 is a critical cytokine in modulating tissue responses during inflammation. IL-22 is upregulated in many chronic inflammatory diseases, making IL-22 biology a potentially rewarding therapeutic target. However, this is complicated by the dual-natured role of IL-22 in inflammation, as the cytokine can be protective or inflammatory depending on the disease model. Although scientific interest in IL-22 has increased considerably in the past 10 y, there is still much we do not know about the environmental, cellular, and molecular factors that regulate the production and function of this cytokine. A better understanding of IL-22 biology will allow us to develop new or improved therapeutics for treating chronic inflammatory diseases. In this article, I will highlight some of the outstanding questions in IL-22 biology.

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“… 125 In addition, IL‐22 can promote the restitution of mucin‐producing goblet cells by activating STAT3. The most common way in which IL‐22 acts is to induce activation of the JAK1/STAT3 pathway and phosphorylation of Jak1 and Tyk2 128–131 . Whether these IL‐22‐mediated pathways can promote mucin secretion requires further investigation.…”

Section: Characteristics Of Mucin Hypersecretion In Different Endotyp...mentioning

confidence: 99%

“…The most common way in which IL‐22 acts is to induce activation of the JAK1/STAT3 pathway and phosphorylation of Jak1 and Tyk2. 128 , 129 , 130 , 131 Whether these IL‐22‐mediated pathways can promote mucin secretion requires further investigation.…”

Section: Characteristics Of Mucin Hypersecretion In Different Endotyp...mentioning

confidence: 99%

Characteristics of mucin hypersecretion in different inflammatory patterns based on endotypes of chronic rhinosinusitis

Zhai,

Shao,

et al. 2024

Clinical & Translational All

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BackgroundChronic rhinosinusitis (CRS) is usually accompanied by mucin hypersecretion that can lead to mucus accumulation and impair nasal mucociliary clearance, thus exacerbating airway inflammation. Abnormal mucin hypersecretion is regulated by different T helper (Th) cytokines, which are associated with different endotype‐driven inflammatory responses. Therefore, it is of great significance to understand how these factors regulate mucin hypersecretion to provide precise treatment strategies for different endotypes of CRS.BodyThus far, the most common endotypes of CRS are classified as type 1, type 2, or type 3 immune responses based on innate and adaptive cell‐mediated effector immunity, and the representative Th cytokines in these immune responses, such as IFN‐γ, TNF‐α, IL‐4, IL‐5, IL‐13, IL‐10, IL‐17, and IL‐22, play an important regulatory role in mucin secretion. We reviewed all the related literature in the PubMed database to determine the expression of these Th cytokines in CRS and the role they play in the regulation of mucin secretion.ConclusionWe believe that the main Th cytokines involved in specific endotypes of CRS play a key role in regulating abnormal mucin secretion, which contributes to better understanding of the pathogenesis of CRS and provides therapeutic targets for airway inflammatory diseases associated with mucin hypersecretion.

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IL-22 deficiency increases CD4 T cell responses to mucosal immunization

Cited by 4 publications

References 38 publications

A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration

A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration

IL-22: There Is a Gap in Our Knowledge

Characteristics of mucin hypersecretion in different inflammatory patterns based on endotypes of chronic rhinosinusitis

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