IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease

Chi, Wei; Yang, Peizeng; Li, Bing; Wu, Changyou; Jin, Haoli; Zhu, Xuefei; Chen, Lina; Zhou, Hongyan; Huang, Xin; Kijlstra, Aize

doi:10.1016/j.jaci.2007.01.010

Cited by 185 publications

(135 citation statements)

References 33 publications

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“…Th17 may be important in the development and progression of inflammatory and autoimmune diseases and Tregs are characterized by their immunoregulatory ability to inhibit the development of certain autoimmune diseases in animal models. Both T helper subsets were described in VKH (14)(15) .…”

Section: Role Of Cd4 + T Cellsmentioning

confidence: 99%

New insights into Vogt-Koyanagi-Harada disease

Damico

Bezerra²,

Silva³

et al. 2009

Arq. Bras. Oftalmol.

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Section: Role Of Cd4 + T Cellsmentioning

confidence: 99%

New insights into Vogt-Koyanagi-Harada disease

Damico

Bezerra²,

Silva³

et al. 2009

Arq. Bras. Oftalmol.

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“…Interleukin-17-producing T (Th17) cells produce TNF-a, IL-21, IL-22, granzyme B, contribute to host defense against microbial agents and have recently been implicated in the development of chronic inflammation in several mouse models [3][4][5], suggesting that the Th17 subset may also be involved in the pathogenesis of immune-mediated diseases in humans, including uveitis. Several studies have reported that IL-23 and IL-17 are elevated in Behc -et's and VKH patients with active uveitis [6][7][8][9], while elevated serum levels of IL-23 and Th17-induced cytokines were found to correlate with intraocular inflammation after cataract surgery in VKH patients [10]. In addition, effective anti-uveitic drugs such as cyclosporine A, daclizumab, rapamycin and dexamethasone mediate their effects in part, by inhibiting production of IL-17 [11,12].…”

Section: Introductionmentioning

confidence: 99%

Persistence of IL‐2 expressing Th17 cells in healthy humans and experimental autoimmune uveitis

Golestaneh

et al. 2011

Eur J Immunol

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Compared with other T‐helper subsets, Th17 cell numbers are very low in human blood but become elevated in chronic inflammatory diseases. In this study, we investigated mechanisms that may explain the frequent involvement of Th17 cells in autoimmune diseases such as uveitis. We compared Th17 and Th1 subsets and found that Th17 cells expressed lower IL‐2 levels during Ag‐priming and this correlated with their decreased susceptibility to activation‐induced cell death (AICD). However, complete depletion of IL‐2 with IL‐2 neutralizing antibodies rendered Th17 cells as susceptible to apoptosis as Th1 cells, suggesting that the low levels of IL‐2 produced by Th17 cells conferred survival advantages to this subset. We describe here a Th17 subtype that constitutively produces very low levels of IL‐2 (Th17‐DP). The Th17‐DP population increased dramatically in the blood and retina of mice during experimental autoimmune uveitis, indicating their potential involvement in the etiology of uveitis. We further show that the majority of the memory Th17 cells in human blood are Th17‐DP and are targets of daclizumab, an IL‐2R antibody used in treating recalcitrant uveitis. Thus, Th17 cells may persist in tissues and contribute to chronic inflammation by limiting IL‐2 production to levels that cannot provoke IL‐2‐induced AICD yet are sufficient to promote Th17 homeostatic expansion.

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“…Moreover, recent studies have indicated that the imbalance of Th1/Th2 and Th17/Treg cells may be responsible for the development and progression of VKH disease. [7] Similarly, it has been demonstrated that the frequency of Th1 and T17 cells is significantly higher in the peripheral blood of RA patients than in healthy controls, whereas Th2 and Treg cells showed some degree of decrease. [8] T helper cell subsets secrete different cytokines which regulate leukocyte trafficking under physiological and pathological conditions.…”

Section: Discussionmentioning

confidence: 93%

“…furthermore, Th1-and T17-related cytokine dominance has also been demonstrated for both diseases. [7,8] ımmunogenetic analysis has indicated a strong association between HlA and VKH, including HlA-DR4, HlA-DRb1, and HlADRw53. ın fact, HlADRb1*0405, one of the subtypes of DR4, is the most frequently found genetic allele in VKH patients.…”

Section: Discussionmentioning

confidence: 99%

Vogt-Koyanagi-Harada Disease Associated with Rheumatoid Arthritis

et al. 2013

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Otuz bir yaşında erkek hasta, iki taraflı bulanık görme ve fotofobi yakınmaları ile kliniğimize başvurdu. Hastanın aynı zamanda şiddetli baş ağrısı, çınlama ve sabah tutukluğu ve artralji yakınmaları vardı. Hastanın tıbbi öyküsünde sekiz yıldır romatoid artrit (RA) nedeniyle tedavi edildiği öğrenildi. Düzeltilmiş görme keskinliği sol gözde 20/50 ve sağ gözde 20/40 düzeyindeydi. Oküler muayenede iki taraflı panüveit ve seröz retina dekolmanı izlendi. Optik koherens tomografide (OCT) iki taraflı subretinal sıvı varlığı tespit edilirken, floresein anjiyografide (FA) "yıldızlı gökyüzü" görünümü ve optik disk boyanması gözlendi. Klinik, FA ve OCT bulguları ışığında hastaya Vogt-Koyanagi-Harada (VKH) hastalığı tanısı konuldu. Sonuç olarak, RA ve VKH hastalığı, etyopatogenezinde çeşitli benzer genetik ve çevresel faktörleri paylaşmaktadır. Bu nedenle bu iki otoimmün hastalık arasındaki ilişkiyi ortaya koyan ileri araştırmalar gerekmektedir.Anahtar sözcükler: Romatoid artrit; seröz retina dekolmanı; VogtKoyanagi-Harada hastalığı.A 31-year-old male patient was admitted to our eye clinic with the complaints of bilateral blurred vision and photophobia. He also suffered from a severe headache, tinnitus, morning stiffness, and arthralgias. His medical history revealed that he had been receiving care for rheumatoid arthritis (RA) for eight years. The best corrected visual acuity was 20/50 in the left eye and 20/40 in the right. His ocular examination revealed bilateral panuveitis with serous retinal detachment. Optical coherence tomography (OCT) confirmed the presence of bilateral subretinal fluid, while fluorescein angiography (FA) demonstrated a "starry sky" appearance and optic disc staining. The patient was diagnosed with Vogt-Koyanagi-Harada (VKH) disease based on the clinical, FA, and OCT findings. In conclusion, both RA and VKH disease share many similar genetic and environmental factors in their etiopathogenesis. Therefore,further investigations are required to confirm the association between these two autoimmune diseases.

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IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease

Cited by 185 publications

References 33 publications

New insights into Vogt-Koyanagi-Harada disease

New insights into Vogt-Koyanagi-Harada disease

Persistence of IL‐2 expressing Th17 cells in healthy humans and experimental autoimmune uveitis

Vogt-Koyanagi-Harada Disease Associated with Rheumatoid Arthritis

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