IL-27 rs153109 polymorphism increases the risk of colorectal cancer in Chinese Han population

Lyu, Shixu; Ye, Lechi; Wang, Ouchen; Huang, Guiqian; Yang, Fan; Liu, Yehuan; Dong, Siyang

doi:10.2147/ott.s80255

Cited by 15 publications

(11 citation statements)

References 21 publications

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“…These findings suggested that IL-27 may lose its tumor suppressive role, which also provides an explanation for the high serum levels of IL-27 in the patients with CRC. A previous study revealed that the IL-27 polymorphism is associated with a high risk of CRC ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

“…By contrast, IL-27, a member of the IL-12 cytokine family, has demonstrated antitumor activity via stimulation of cytotoxic T cells and natural killer cell function, regulating the differentiation of T cell subsets, and suppressing dendritic cell function and angiogenesis ( 16 ). In addition, IL-27 gene polymorphisms have been revealed to increase the risk of CRC development ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

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Association between the serum concentrations and mutational status of IL‑8, IL‑27 and VEGF and the expression levels of the hERG potassium channel gene in patients with colorectal cancer

2021

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The present study aimed to determine the diagnostic value of the serum levels and mutational status of IL-8, IL-27 and VEGF, and the expression levels of human ether-a-go-go-related gene (hERG) in patients with colorectal cancer (CRC). The serum concentrations were determined using the ELISA technique and genotype variations of IL-8, IL-27 and VEGF were examined using Sanger sequencing, and the expression levels of hERG, which encodes a potassium channel, were determined by quantitative PCR, in blood and tissue samples obtained from 80 patients with CRC and 80 healthy individuals. The results of the present study revealed that the percentage of granulocytes and serum concentrations of carcinoembryonic antigen, IL-8 and IL-27 were significantly increased, whereas the percentage of lymphocytes was decreased in patients with CRC. In total, 31 mutations in three genes (eight mutations in VEGF, 13 mutations in IL-27 and 10 mutations in IL-8) were identified in patients with CRC. The relative mRNA expression levels of hERG were also significantly upregulated in tissue and blood samples of patients with CRC compared with those of healthy individuals. In conclusion, the results of the present study indicated that the increased concentrations and genetic variations of IL-8, IL-27 and VEGF may serve important roles in the development and angiogenic processes of CRC. These changes were concomitant with the upregulation of the expression levels of the potassium channel hERG.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between the serum concentrations and mutational status of IL‑8, IL‑27 and VEGF and the expression levels of the hERG potassium channel gene in patients with colorectal cancer

2021

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“…Several studies examined the association between DOI:10.31557/APJCP.2020.21.9.2507 IL-27 polymorphisms and the risk of various cancer (Wei et al, 2009;Zhao et al, 2009;Guo et al, 2012;Huang et al, 2012;Pan et al, 2012;Tao et al, 2012;Peng et al, 2013;Munretnam et al, 2014;Tang et al, 2014;Zhang et al, 2014a;Zhang et al, 2014b;Lyu et al, 2015;Pu et al, 2015;Zhang et al, 2015;Zhou et al, 2015;Ge and Xiao, 2016;Wang et al, 2016;Yu et al, 2016;Nie et al, 2017;Ghavami et al, 2018). The findings were controversial, though it is difficult to clarify the inconsistent findings.…”

Section: Discussionmentioning

confidence: 99%

“…It is well-known that IL-27 possesses antitumor activities against a variety of tumor types (Nagai et al, 2010;Di Carlo et al, 2014;Yoshida and Hunter, 2015;Yoshimoto et al, 2015). IL-27 is a polymorphic gene and several studies examined the association between IL-27 gene polymorphisms and risk of various cancers including, non-small-cell lung cancer (NSCLC) (Ge and Xiao, 2016), acute lymphoblastic leukemia (ALL) (Ghavami et al, 2018), nasopharyngeal carcinoma (NPC) (Wei et al, 2009;Pan et al, 2012), colorectal cancer (CRC) (Guo et al, 2012;Huang et al, 2012;Lyu et al, 2015), prostate cancer (PCa) (Munretnam et al, 2014), papillary thyroid carcinoma (PTC) (Zhang et al, 2015;Nie et al, 2017), hepatocellular carcinoma (HCC) (Peng et al, 2013), renal cell carcinoma (RCC) (Pu et al, 2015), osteosarcoma (Tang et al, 2014), esophageal cancer (Tao et al, 2012), cervical cancer (Wang et al, 2016), endometrial cancer (Yu et al, 2016), ovarian cancer (Zhang et al, 2014b), breast cancer (Zhang et al, 2014a), glioma (Zhao et al, 2009), and bladder cancer (Zhou et al, 2015). However, the findings of these studies have been controversial.…”

Section: Introductionmentioning

confidence: 99%

Association between IL-27 Gene Polymorphisms and Cancer Susceptibility in Asian Population: A Meta-Analysis

Moazeni‐Roodi

Hashemi

Ghavami

2020

Asian Pac J Cancer Prev

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Background: Interleukin 27 (IL-27) has potent antitumor activity. Several epidemiological studies have designated that genetic variants of the IL-27 gene may contribute to various cancer susceptibility, but the data were inconclusive. Objective: The current meta-analysis aimed to address the association between IL-27 rs153109, rs17855750, and rs181206 polymorphisms and the risk of cancer. Data Sources: Our team has selected eligible studies up to May 1, 2020, from several electronic databases, including Web of Science, PubMed, Scopus, and Google Scholar databases. Results: Our meta-analysis revealed that the carriers rs153109 A>G polymorphism in the IL-27 gene have higher risks of diseases in the heterozygous (OR=1.26, 95%CI=1.06-1.49, P=0.007, AG vs AA), homozygous (OR=1.18, 95%CI=1.01-1.37, p=0.33, GG vs AA), dominant (OR=1.25, 95%CI=1.07-1.47, P=0.006, AG+GG vs AA), and allele (OR=1.15, 95%CI=1.04-1.27, P=0.008, G vs A) genetic models. Stratified analysis by cancer type indicated that this variant was significantly associated with gastrointestinal cancer, colorectal cancer and breast cancer. The findings did not support an association between rs17855750 T>G, rs181206 T>C polymorphisms of IL-27 and cancer risk. Conclusion: the current study findings suggest that IL-27 rs153109 polymorphism significantly increased the risk of cancer susceptibility. Well-designed replication in a larger independent genetic association study with larger sample sizes in diverse ethnicities is required to verify the findings.

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“…12 Additionally, relationships between polymorphisms and cytokine levels, including those of TGFβ1 and IL-10, -22, and -27, have been reported in CRC patients. [14][15][16][17] However, the effects of these cytokine gene polymorphisms on CRC patients in Saudi Arabia are understudied. The present study aims to explore how CRC patients in Saudi Arabia are affected by the presence of several specific cytokine polymorphisms: IL-8 (rs4073 T/A), IL-10 (rs1800896 A/G), IL-22 (rs1179251 C/G and rs2227485 C/T), IL-27 (rs17855750 T/G), and TGFß1 (rs1800469 C/T).…”

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confidence: 99%

A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer

Althubyani

Alkhuriji

Alomar

et al. 2020

SMJ

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IL-27)rs17855750T / G) ‫أليل‪G‬‬ ‫و‬ G ‫1529711‪))rs‬أليل‬ C/G ‫اجلينية‬ ‫األمناط‬ ‫كان‬ ‫قيما‬ CT,TT)TGFß1)rs1800469 C / T‫و‬ IL-10)rs1800896 A/G) ‫و‬ TGFß1)rs1800469 C/T)CC ‫ـ‬ ‫ل‬ ‫اجليني‬ ‫األشكال‬ ‫تعدد‬ ‫بني‬ ‫ارتباطات‬ ‫حتدد‬ ‫لم‬ ‫باملرض.‬ ‫لإلصابة‬ ‫محفزا‬ AA ‫سرطان‬ ‫وخطر‬ IL-22)rs2227485 C/T) ‫و‬)IL-8)rs4073 T/A ‫واملستقيم.‬ ‫القولون‬ IL-10)rs1800896 ‫األشكال‬ ‫ـتعدد‬ ‫ل‬ ‫الكبير‬ ‫لتأثير‬ ‫النتائج‬ ‫تشير‬ ‫اخلالصة:‬)IL-27)rs17855750 T/G ‫و‬)IL-22)rs1179251 C/G ‫و‬)A/G ‫لم‬ ‫واملستقيم؛‬ ‫القولون‬ ‫سرطان‬ ‫خطر‬ ‫على‬ TGFß1)rs1800469 C/T) ‫و‬ IL-22)rs2227485)‫و‬)IL-8)rs4073T/A ‫األشكال‬ ‫تعدد‬ ‫يترافق‬ ‫واملستقيم.‬ ‫القولون‬ ‫سرطان‬ ‫خطر‬ ‫مع‬ C/T Objectives: To determine the possible associations of polymorphisms in interleukin (IL)-8 (rs4073 T/A), IL-10 (rs1800896 A/G), IL-22 (rs1179251 C/G and rs2227485 C/T), IL-27 (rs17855750 T/G), and transforming growth factor beta 1 (TGFß1) (rs1800469 C/T) with colorectal cancer (CRC) susceptibility in Saudi patients. Methods: The case-control study was carried out between July 2019 and January 2020 in King Khaled University Hospital, Riyadh, Saudi Arabia. A total of 70 patients with CRC and 70 healthy controls were included in the study. Single nucleotide polymorphisms Original Article of promoter regions were determined using TaqMan genotyping assays. Results: A statistically significant reduction in CRC risk was identified for carriers of the IL-10 (rs1800896 A/G) AG genotype, IL-22 (rs1179251 C/G) G allele, IL-27 (rs17855750 T/G) G allele and TGFß1 (rs1800469 C/T) CT and TT genotype. While IL-10 (rs1800896 A/G) AA genotype and TGFß1 (rs1800469 C/T) CC genotype were significantly associated with increased susceptibility to CRC. No significant associations were identified between the cytokine polymorphisms of IL-8 (rs4073 T/A) and IL-22 (rs2227485 C/T), and CRC risk. Conclusion: Our findings indicate a significant impact of IL-10 (rs1800896 A/G), IL-22 (rs1179251 C/G), IL-27 (rs17855750 T/G) and TGF-ß1 (rs1800469 C/T) polymorphisms on risk of CRC; while the IL-8 (rs4073 T/A) and IL-22 (rs2227485 C/T) and polymorphisms were not associated with CRC risk.

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IL-27 rs153109 polymorphism increases the risk of colorectal cancer in Chinese Han population

Cited by 15 publications

References 21 publications

Association between the serum concentrations and mutational status of IL‑8, IL‑27 and VEGF and the expression levels of the hERG potassium channel gene in patients with colorectal cancer

Association between the serum concentrations and mutational status of IL‑8, IL‑27 and VEGF and the expression levels of the hERG potassium channel gene in patients with colorectal cancer

Association between IL-27 Gene Polymorphisms and Cancer Susceptibility in Asian Population: A Meta-Analysis

A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer

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