IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: Role in the course of chronic viral hepatitis and the development of HCC

Fabris, Carlo; Falleti, Edmondo; Cussigh, Annarosa; Bitetto, Davide; Fontanini, Elisabetta; Bignulin, S.; Cmet, Sara; Fornasiere, Ezio; Fumolo, Elisa; Fangazio, Stefano; Cerutti, Andrea; Minisini, Rosalba; Pirisi, Mario; Toniutto, Pierluigi

doi:10.1016/j.jhep.2010.07.019

Cited by 162 publications

(138 citation statements)

References 32 publications

Supporting

Mentioning

121

Contrasting

Unclassified

Order By: Relevance

“…After our selection, 7 casecontrol studies including 1152 HCC and/or LC cases and 1326 controls fulfilled the inclusion criteria (Barreiro et al, 2011;Fabris et al, 2011;Falleti et al, 2011;Agundez et al, 2012;El-Awady et al, 2012;Eurich et al, 2012;Ren et al, 2012). The quality of the studies was considered acceptable for our meta-analysis.…”

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: a meta-analysis

Suo¹,

Zhao²

2013

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. We examined the association of the interleukin-28B (IL-28B) gene rs12979860 T/C polymorphism with development of hepatitis virus-related hepatocellular car cinoma (HCC) and liver cirrhosis (LC). Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library, and Chinese National Knowledge Infrastructure data bases. Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) for rs12979860 and HCC/LC were cal culated in a fixed-effect model (the Mantel-Haenszel method) and a random-effect model (the DerSimonian and Laird method) when appropriate. This meta-analysis included 7 eligible studies, with 1152 HCC and/or LC cases and 1326 controls. Overall, the rs12979860 T/C polymorphism was significantly as sociated with risk of hepatitis virusrelated HCC and LC development (TT vs CC+CT, pooled OR = 1.597, 95%CI = 1.254-2.036). When they were grouped by type of hepatitis virus, similar results were found for hepatitis C virus-related groups (TT vs CC+CT, pooled OR = 1.732, 95%CI = 1.343-2.235, P value < 0.0001). In the overall analysis, the IL-28B rs12979860 T/C polymorphism was 3709 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (3): 3708-3717 (2013) 28B gene polymorphism and hepatocellular cancer identified as a genetic risk factor for hepatitis virus-related HCC and LC development. A significant increase in the frequency of the T/T genotype was detected from chronic hepatitis to HCC and LC.

show abstract

Section: Study Characteristicsmentioning

confidence: 99%

“…There were 3 case-control studies (Barreiro et al, 2011;Fabris et al, 2011;, which had been performed to study the rs12979860 poly morphism and LC risk. The results of the meta-analysis are shown in Table 3.…”

Section: Evaluation Of the Il-28b Rs12979860 Polymorphism And Associamentioning

confidence: 99%

Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: a meta-analysis

Suo¹,

Zhao²

2013

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…Analyzing the results obtained in Italy, Germany or Hungary, it can be observed that the prevalence of people with genotype CT remains at a very similar level of about 50%, while with genotype TT constitutes more than 10% of the examined patients. [13][14][15] This is explained by the hypothesis that the variant TT may have a protective effect against acute infection occurrence. 8 Comparison of the frequency of particular variants in different research studies reveals significant discrepancies.…”

Section: Discussionmentioning

confidence: 99%

Distribution of polymorphisms rs12979860, rs8099917 and rs12980275 IL28B in patients with chronic hepatitis C

et al. 2017

View full text Add to dashboard Cite

Background. The prognosis concerning the treatment of patients with chronic hepatitis C (CHC) is closely related to the genotype of the virus as well as to the factors dependent on the patient. It was proved that polymorphisms of the gene encoding interleukin 28B (IL28B) are associated with sustained viral response, which in the case of profitable variants of IL28B polymorphisms may reach up to 87% of the patients.

show abstract

“…Favorable IL28B variants, likely through the effect of inflammatory cytokines on lipid metabolism [23], protect against the development of steatosis [24] and possibly steatosis-associated fibrosis progression and increased HCC risk [2,4]. As a result, IL28B variants likely have no major effect on the fibrosis-progression rate in patients with ongoing HCV infection [6], even if evidence is still controversial [25]. Even scanty data are available on the possible role of IL28B polymorphisms in determining the risk of HCC, and although a higher prevalence of unfavorable genotypes has been reported in one series, results were not controlled for the outcome of antiviral therapies [25].…”

mentioning

confidence: 99%

“…As a result, IL28B variants likely have no major effect on the fibrosis-progression rate in patients with ongoing HCV infection [6], even if evidence is still controversial [25]. Even scanty data are available on the possible role of IL28B polymorphisms in determining the risk of HCC, and although a higher prevalence of unfavorable genotypes has been reported in one series, results were not controlled for the outcome of antiviral therapies [25].…”

mentioning

confidence: 99%

IL28B, HCV core mutations, and hepatocellular carcinoma: does host genetic make-up shape viral evolution in response to immunity?

2011

View full text Add to dashboard Cite

Mutations in the core sequence of the HCV genome have been reported to influence treatment response, fibrosis progression, and hepatocarcinogenesis in Asian patients with genotype-1 chronic hepatitis C (CHC). In this issue, Miura et al. report data consistent with a causal relationship between the R70 ? Q70 core variant and hepatocellular carcinoma (HCC) risk in CHC genotype-1b patients, by the prospective evaluation of changes in the consensus sequence in the entire open reading frame between treatment failure and HCC development or end of follow-up, and validation of the initial findings in a confirmatory cohort. Furthermore, they observed an association between the IL28B genotype, which is believed to influence the immune response to viral infection, and the direction of time-dependent changes in core residue 70, with unfavorable IL28B genotypes linked to a preferential shift to the 70Q associated with HCC. Although this association needs to be validated in independent cohorts, and IL28B variants did not influence HCC risk, these results suggest that IL28B genotype might not only influence the behavior of the innate immune system in the presence of HCV genotype-1 infection but also shape the resultant viral evolution, with possible consequences on major clinical outcomes, such as HCC development, and treatment response.

show abstract

IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: Role in the course of chronic viral hepatitis and the development of HCC

Cited by 162 publications

References 32 publications

Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: a meta-analysis

Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: a meta-analysis

Distribution of polymorphisms rs12979860, rs8099917 and rs12980275 IL28B in patients with chronic hepatitis C

IL28B, HCV core mutations, and hepatocellular carcinoma: does host genetic make-up shape viral evolution in response to immunity?

Contact Info

Product

Resources

About