IL‐6(−572/−597) polymorphism and expression in HBV disease chronicity in an Indian population

Saxena, Rahul; Chawla, Yogesh; Verma, Indu; Kaur, Jyotdeep

doi:10.1002/ajhb.22562

Cited by 18 publications

(13 citation statements)

References 30 publications

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“…Furthermore, the IL-6 (-597G>A) GA genotype was potentially protective against hepatitis, cirrhosis, and subsequent HCC development in carriers. 69 In conclusion, these data illustrate how SNPs in the IL-6 gene promoter fundamentally determine low and high risk among HBV- infected patients.…”

Section: Il-6 Gene Polymorphism and Hbv Infectionmentioning

confidence: 78%

IL-6 Plays a Crucial Role in HBV Infection

Lan

Chang

et al. 2015

JCTH

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Interleukin-6 (IL-6), a cytokine mainly produced by activated monocytes, has broad pleiotropic actions that affect the functions of a variety of lymphoid cells. The roles of IL-6 in regulating immunity to infections are currently being defined. Remarkably, IL-6-mediated cellular and humoral immune responses play a crucial role in determining the outcome of viral infection. This article reviews the current knowledge on the critical role of IL-6 in hepatitis B virus (HBV) infection. As a competent intermediary, IL-6 derived from activated monocytes plays an important role in promoting lymphocytes responses that are essential for effective viral control. However, as a mediator of inflammation, IL-6 is also involved in the development of HBV-induced liver cirrhosis and exacerbating liver injury. Overall, the current data point to IL-6 as an immunoregulatory cytokine in HBV infection. Immunotherapeutic strategies aimed at optimizing the beneficial effects of IL-6 in HBV infection may prove to be an ordeal in the future, as they should foster the strengths of IL-6 while circumventing potential drawbacks.

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Section: Il-6 Gene Polymorphism and Hbv Infectionmentioning

confidence: 78%

IL-6 Plays a Crucial Role in HBV Infection

Lan

Chang

et al. 2015

JCTH

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“…1), 25 case-control studies including 5813 cases and 5298 controls were finally included for this meta-analysis. [12][13][14][15][16][18][19][20][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] Among these 25 studies published between 2005 and 2018, 17 of them with 20 datasets investigated the associations between rs1800795 polymorphism of IL-6 gene and liver diseases (including 1 for autoimmune hepatitis, 3 for HBV infection, 4 for NASH, 4 for HCV infection, 3 for LC, 1 for HEV infection, 2 for HCC and 2 for alcoholic liver disease), 8 studies with 16 datasets involved rs1800796 (including 6 for HBV infection, 2 for HCV infection, 1 for HIV infection, 3 for LC, 3 for HCC and 1 for LC/HCC), 5 studies with 8 datasets analyzed rs1800797 (including 3 for HBV infection, 1 for HCV infection, 2 for LC and 2 for HCC), 4 studies with 5 datasets explored rs2069837 (including 2 for HBV infection, 1 for anti-tuberculosis drug-induced hepatitis, 1 for LC-HCC and 1 for HCC) and 3 studies with 4 datasets surveyed rs2066992 (including 2 for HBV infection, 1 for anti-tuberculosis drug-induced hepatitis and 1 for LC-HCC). According to the NOS, all the included studies were of high quality.…”

Section: Study Characteristicsmentioning

confidence: 99%

Interleukin-6 gene polymorphisms and susceptibility to liver diseases

Wang

Yan

2019

Medicine

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Background: Several studies have explored the associations between interleukin-6 (IL-6) gene polymorphisms and the susceptibility to liver diseases, however, results remain ambiguous. The goal of this study was to conduct a meta-analysis to provide more credible evidence.Methods: Studies identified in the PubMed, Cochrane Library, and EMBASE databases were used to perform a meta-analysis via the STATA software. Pooled odds ratios (OR) were calculated under fixedand random-effects models to estimate the potential genetic associations.Results: Twenty-five case-control studies involving 5813 cases and 5298 controls were included in this meta-analysis. Overall, the pooled results suggested that rs1800795 polymorphism was significantly associated with the risk of liver diseases in heterozygote (GC vs CC; OR = 1.57) and dominant (GG+GC vs CC: OR = 1.47) models; rs1800796 polymorphism was significantly associated with the susceptibility to liver diseases in heterozygote (GG vs GC; OR = 0.58) and recessive (GG vs GC+CC: OR = 0.68) models; rs1800797 polymorphism was significantly associated with genetic predisposition to liver diseases in homozygote (GG vs AA: OR = 1.63), heterozygote (GA vs AA; OR = 1.53) and dominant (GG + GA vs AA: OR = 1.61) models. A similar conclusion was found in the HBV, HCV, HCC, NASH and alcoholic liver disease of all ethnic populations for rs1800795; HBV and Asian subgroups for rs1800796; HCV and non-Asian subgroups for rs1800797. However, IL-6 rs2069837 and rs2066992 polymorphisms did not exhibit significant associations with the risk of liver diseases under any genetic models. Conclusion:This meta-analysis suggests that patients carrying G (rs1800795), C (rs1800796) or G (rs1800797) allele or genotypes of IL-6 may be more likely to suffer from liver diseases, which was ethnic-dependent.Abbreviations: CI = confidence interval, HBV = hepatitis B virus, HC = healthy, HCC = hepatocellular carcinoma, HCV = hepatitis C virus, HIV = human immunodeficiency virus-type 1, IF = infection resolved, IL-6 = interleukin-6, LC = liver cirrhosis, NASH = nonalcoholic steatohepatitis, NOS = New-castle-Ottawa Scale, OR = odds ratio, PRISMA = Preferred Reporting Items for Systematic Review and Meta-analysis, SNP = single nucleotide polymorphism, STAT3 = signal transducer and activator of transcription 3.

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“…For IL-6 rs1800796, the genotypes GG and GC containing the protective allele G were more frequently identified among healthy controls as compared with chronic HBV patients. Saxena et al (27) similarly reported that the GG genotype of IL-6 rs1800796 was more frequent in healthy controls as compared with chronic HBV patients. However, for IL-6 rs2066992, genotypes GG and GT containing the protective allele G were predominant among healthy controls as compared with chronic HBV patients (27).…”

Section: Discussionmentioning

confidence: 95%

Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population

et al. 2018

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Interleukin-6 (IL-6) is a cytokine with a critical role in regulating the immune response to infectious disease. Studies have indicated that polymorphisms in the IL-6 gene may be linked to hepatitis B virus (HBV) infection. The purpose of the present study was to examine the association among IL-6 SNPs and haplotypes with HBV infection risk in a Malaysian population. A total of 1,246 Malaysian subjects with and without chronic hepatitis B were recruited for this study. Three IL-6 polymorphisms (rs2069837, rs1800796 and rs2066992) were genotyped using a Sequenom MassARRAY ® platform. The results suggested that GC and CC genotypes of rs1800796 as well as GT and TT genotypes of rs2066992 were associated with protection against HBV infection (P<0.001). Furthermore, haplotypes GG and CT exhibited a significant association with protection against HBV (P=0.003 and =0.005, respectively); and haplotypes GG and CT exhibited a significant association with clearance of HBV infection (P=0.035 and =0.037, respectively). The present study indicates that two IL-6 SNPs (rs1800796 and rs2066992) are associated with clearance of chronic HBV or protection against HBV infection at allelic, genotypic and haplotypic levels.

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IL‐6(−572/−597) polymorphism and expression in HBV disease chronicity in an Indian population

Abstract: These preliminary findings indicate a potential role of IL-6(-572/-597) genotypes in HBV disease pathogenesis in an Indian population.

Cited by 18 publications

References 30 publications

IL-6 Plays a Crucial Role in HBV Infection

IL-6 Plays a Crucial Role in HBV Infection

Interleukin-6 gene polymorphisms and susceptibility to liver diseases

Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population

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