IL-8 -251T/A polymorphism is associated with susceptibility to acute pancreatitis

Abstract

ABSTRACT. We conducted a case-control study to clarify the associations between inflammatory cytokine, including interleukin (IL)-1b, IL-6, IL-8, and IL-10, polymorphisms and risk of acute pancreatitis.

Role of IL-10 gene polymorphisms in the development of acute pancreatitis

“…Correlations between the IL-10 gene polymorphism and the development of acute pancreatitis have been investigated in several studies, and the results were inconclusive (Sargen et al, 2000;Schneider et al, 2004a,b;Zhang et al, 2005;de-Madaria et al, 2008;Bao et al, 2015;Li et al, 2015). Zhang et al (2005) conducted a study in a Chinese population, and they reported that the IL-10 -1082A/G gene polymorphism plays an important role in the susceptibility of acute severe pancreatitis.…”

Investigation of the association between Interleukin-10 polymorphisms and risk of acute pancreatitis in a Chinese population

“…Several previous studies have reported the association between interleukin gene polymorphisms and acute pancreatitis (Schneider et al, 2004;Chen and Nie, 2008;Bao et al, 2015;Chi et al, 2015). Schneider et al (2004) investigated the role of TNF-α, TGF-β1, IL-10, and IFN-γ gene polymorphisms in the development of alcoholic chronic pancreatitis, but they did not find that genetic variants played a dominant role in alcoholic chronic pancreatitis.…”

“…IL-10 is an immunoregulatory cytokine located on chromosome 1 (1q31-1q32), and this protein is produced by Th2 cells and monocytes. A few studies reported an association between IL-10 gene polymorphisms and acute pancreatitis, but the results are inconclusive (Yin et al, 2013;Bao et al, 2015). Therefore, we conducted a case-control study to investigate the possible association between three common single nucleotide polymorphisms in IL-10 and the development of acute pancreatitis in a Chinese population.…”

“…However, not all subjects with similar risk factors develop acute pancreatitis, which suggests that genetic variations could influence the development of the condition. Several studies have reported that genetic polymorphisms play an important role in the development of acute pancreatitis such as interleukin-8 (IL-8), IL-1β, IL-6, toll-like receptor, and tumor necrosis factoralpha (TNF-α) genes (Yin et al, 2012;Yin et al, 2013;Bao et al, 2015;Chi et al, 2015;MatasCobos et al, 2015).…”

Influence of interleukin-18 gene polymorphisms on acute pancreatitis susceptibility in a Chinese population

“…Not all individuals subject to acute pancreatitis risk factors go on to develop this disease, which indicates that genetic influences may contribute to the development of this disease. Recently, many studies have suggested that interleukin (IL) genes, such as IL-10, play an important role in the development of acute pancreatitis (Bao et al, 2015b;Chi et al, 2015;Jia et al, 2015;Li et al, 2015a).…”