IL17 factors are early regulators in the gut epithelium during inflammatory response to Vibrio in the sea urchin larva

Buckley, Katherine M.; Ho, Eric Chun Hei; Hibino, Taku; Schrankel, Catherine S.; Schuh, Nicholas W; Wang, Guizhi; Rast, Jonathan P.

doi:10.7554/elife.23481

Cited by 59 publications

(65 citation statements)

References 88 publications

(147 reference statements)

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“…The IL-17 family plays a critical role in the immune response in infectious, inflammatory, autoimmune, and neoplastic disorders [81,82]. The IL-17 family and its receptors are evolutionally ancient, and they are present in species as early as lamprey and sea urchins [83,84]. IL-17 family members comprise IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F, and IL-17AF [81,82].…”

Section: Il-17a Signaling Systemmentioning

confidence: 99%

Interleukin-17A and Keratinocytes in Psoriasis

Furue

Tsuji

et al. 2020

IJMS

190

155

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The excellent clinical efficacy of anti-interleukin 17A (IL-17A) biologics on psoriasis indicates a crucial pathogenic role of IL-17A in this autoinflammatory skin disease. IL-17A accelerates the proliferation of epidermal keratinocytes. Keratinocytes produce a myriad of antimicrobial peptides and chemokines, such as CXCL1, CXCL2, CXCL8, and CCL20. Antimicrobial peptides enhance skin inflammation. IL-17A is capable of upregulating the production of these chemokines and antimicrobial peptides in keratinocytes. CXCL1, CXCL2, and CXCL8 recruit neutrophils and CCL20 chemoattracts IL-17A-producing CCR6+ immune cells, which further contributes to forming an IL-17A-rich milieu. This feed-forward pathogenic process results in characteristic histopathological features, such as epidermal hyperproliferation, intraepidermal neutrophilic microabscess, and dermal CCR6+ cell infiltration. In this review, we focus on IL-17A and keratinocyte interaction regarding psoriasis pathogenesis.

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Section: Il-17a Signaling Systemmentioning

confidence: 99%

Interleukin-17A and Keratinocytes in Psoriasis

Furue

Tsuji

et al. 2020

IJMS

190

155

View full text Add to dashboard Cite

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“…However, the genome sequence contains homologs of tumor necrosis factor α, macrophage inhibitory factor and interleukin 17 (IL17), as well as IL1 receptors ( 23 ). This shared regulatory heritage between echinoderms and vertebrates enables experimental investigations into transcriptional control of immune cell development ( 25 , 26 ) and immune response ( 17 , 29 ) that can provide meaningful insight to vertebrate biology.…”

Section: A Wealth Of Echinoderm Genomic Resources Is Availablementioning

confidence: 99%

“…To identify an early immune signal, an RNA-Seq assay was used to quantify system-wide transcript levels in larvae over a time-course of exposure to V. diazotrophicus . From these data, a small family of genes orthologous to vertebrate IL17 cytokines emerged as the most highly upregulated transcripts across the entire genome ( 29 ). The mammalian IL17 signaling molecules [IL17A–F ( 48 )] are expressed in Th17 cells, and other lymphocytes, myeloid cell types, and barrier tissues ( 49 – 51 ), including gut epithelial cells ( 52 – 54 ).…”

Section: Il17 Cytokines Mediate the Larval Gut-associated Inflammatormentioning

confidence: 99%

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An Organismal Model for Gene Regulatory Networks in the Gut-Associated Immune Response

Buckley

Rast

2017

Front. Immunol.

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The gut epithelium is an ancient site of complex communication between the animal immune system and the microbial world. While elements of self-non-self receptors and effector mechanisms differ greatly among animal phyla, some aspects of recognition, regulation, and response are broadly conserved. A gene regulatory network (GRN) approach provides a means to investigate the nature of this conservation and divergence even as more peripheral functional details remain incompletely understood. The sea urchin embryo is an unparalleled experimental model for detangling the GRNs that govern embryonic development. By applying this theoretical framework to the free swimming, feeding larval stage of the purple sea urchin, it is possible to delineate the conserved regulatory circuitry that regulates the gut-associated immune response. This model provides a morphologically simple system in which to efficiently unravel regulatory connections that are phylogenetically relevant to immunity in vertebrates. Here, we review the organism-wide cellular and transcriptional immune response of the sea urchin larva. A large set of transcription factors and signal systems, including epithelial expression of interleukin 17 (IL17), are important mediators in the activation of the early gut-associated response. Many of these have homologs that are active in vertebrate immunity, while others are ancient in animals but absent in vertebrates or specific to echinoderms. This larval model provides a means to experimentally characterize immune function encoded in the sea urchin genome and the regulatory interconnections that control immune response and resolution across the tissues of the organism.

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“…The role that the sea urchin microbiome plays in immunity has received less attention [17,18]. In other invertebrate taxa, such as insects, the microbiome plays a role in protecting against pathogenic bacteria, while at the same time hosting commensal bacteria [19].…”

Section: Introductionmentioning

confidence: 99%

Ocean warming alters predicted microbiome functionality in a common sea urchin

et al. 2018

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The microbiome of sea urchins plays a role in maintaining digestive health and innate immunity. Here, we investigated the effects of long-term (90 day) exposure to elevated seawater temperatures on the microbiome of the common, subtropical sea urchin The community composition and diversity of microbes varied according to the type of sample collected from the sea urchin (seawater, feed, intestines, coelomic fluid, digested pellet and faeces), with the lowest microbial diversity (predominately the order Campylobacterales) located in the intestinal tissue. Sea urchins exposed to near-future seawater temperatures maintained the community structure and diversity of microbes associated with their tissues. However, marginal, non-significant shifts in microbial community structure with elevated temperature resulted in significant changes in predicted metagenomic functions such as membrane transport and amino acid and carbohydrate metabolism. The predicted changes in key metabolic categories suggest that near-future climate-induced increases in seawater temperature could shift microbial community function and impact sea urchin digestive and immune physiology.

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IL17 factors are early regulators in the gut epithelium during inflammatory response to Vibrio in the sea urchin larva

Cited by 59 publications

References 88 publications

Interleukin-17A and Keratinocytes in Psoriasis

Interleukin-17A and Keratinocytes in Psoriasis

An Organismal Model for Gene Regulatory Networks in the Gut-Associated Immune Response

Ocean warming alters predicted microbiome functionality in a common sea urchin

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