IL18 polymorphism is associated with an increased risk of Crohn’s disease

Tamura, Kazuo; Fukuda, Yoshihiro; Sashio, Hiroko; Takeda, Norihiko; Bamba, Hiroko; Kosaka, Toshio; Fukui, Sei; Sawada, Koji; Tamura, Kouichi; Satomi, Masamichi; Yamada, Takahiro; Yamamura, Takehira; Yamamoto, Yoshihiro; Furuyama, Jun-ichi; Okamura, Haruki; Shimoyama, Takashi

doi:10.1007/bf03326428

Cited by 79 publications

(53 citation statements)

References 29 publications

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“…SNP rs360719A>G (À1297) is at the OCT-1 binding site [29], rs1946518T>G (À607) at a potential cyclic adenosine monophosphate (c-AMP)-responsive element-binding site [10], and rs187238G>C (À137) at a H4TF-1 nuclear factor binding site [10]. These SNPs have been reported to be individually or jointly associated with susceptibility to Crohn disease [30], inflammatory bowel disease [31], type 1 diabetes mellitus [11][12][13], renal manifestations [32] or arthritis in SLE [33], presence of anti-GAD antibody in Graves disease [34], or asthma [35,36]. However, rs1946518 alone is not associated with various autoimmune diseases including type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, Crohn disease and ulcerative colitis in a metaanalysis [37] or with autoimmune thyroid disease [38] or Graves disease [34,39] in other individual studies, nor with HT, in our study.…”

Section: Discussionmentioning

confidence: 97%

The IL18 gene and Hashimoto thyroiditis in children

Huang

Ting

et al. 2013

Human Immunology

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Section: Discussionmentioning

confidence: 97%

The IL18 gene and Hashimoto thyroiditis in children

Huang

Ting

et al. 2013

Human Immunology

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“…This model has also been used to analyze colitisassociated colorectal cancer [38]. IL-1b and IL-18 have key roles in inducing colorectal tumor formation [39][40][41]. One carcinogenic mechanism of this AOM/DSS model may be that IL-1b induced by neutrophils leads to macrophage production of IL-6, as a tumor promoter [42].…”

Section: Gut Microbiota and Experimental Models Of Ibdmentioning

confidence: 99%

A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease

2015

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Intestinal immune homeostasis is regulated by gut microbiota, including beneficial and pathogenic microorganisms. Imbalance in gut bacterial constituents provokes host proinflammatory responses causing diseases such as inflammatory bowel disease (IBD). The development of next-generation sequencing technology allows the identification of microbiota alterations in IBD. Several studies have shown reduced diversity in the gut microbiota of patients with IBD. Advances in gnotobiotic technology have made possible analysis of the role of specific bacterial strains in immune cells in the intestine. Using these techniques, we have shown that Clostridium butyricum as a probiotic induces interleukin-10-producing macrophages in inflamed mucosa via the Toll-like receptor 2/myeloid differentiation primary response gene 88 pathway to prevent acute experimental colitis. In this review, we focus on the new approaches for the role of specific bacterial strains in immunological responses, as well as the potential of bacterial therapy for IBD treatments.

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“…In CD, no significant differences were observed at positions –607 and –137 in this study and in a Japanese one [34]. However, it has been reported that a silent allelic variant in the coding region of IL-18 was associated with CD [35]. We also searched p-ANCA and ASCA antibodies in IBD patients and observed 26% of positivity for p-ANCA in UC patients and 8% in CD patients.…”

Section: Discussionmentioning

confidence: 89%

Interleukin-18 Gene Polymorphisms in Tunisian Patients with Inflammatory Bowel Disease

Aleya

Sfar²,

Habibi³

et al. 2011

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Aim: Interleukin (IL)-18 can regulate the Th2-mediated immune response and it may be involved in the pathogenesis of Th1 and Th2 chronic inflammatory diseases. This study sought to detect a possible association between two single nucleotide polymorphisms (SNPs) (–137G/C and –607C/A) in the IL-18 gene promoter region and susceptibility to inflammatory bowel disease (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) in the Tunisian population. Methods: The (–137G/C and –607C/A) IL-18 polymorphism was analyzed in 105 patients with CD, 59 patients with UC, and 100 controls using the sequence-specific polymerase chain reaction method. Results: The distribution of allele and genotype frequencies illustrate that the –137G/G genotype frequency was significantly higher in UC than in controls (p value corrected (pc) = 0.038). On the other hand, we found a statistically significant association (pc = 0.033) between genotype AA of the IL-18 gene promoter (–607C/A) polymorphism in UC patients and the distal localization of the lesions. In CD, no significant differences were observed at positions –607 and –137. The analysis of IBD patients according to clinical behavior revealed no difference. Conclusion: The two SNPs at position –607 (C/A) and –137 (G/C) in the promoter region of the IL-18 gene was associated with the development of UC but not CD, providing a strong support for an IBD susceptibility gene in the region surrounding IL-18. It remains to be determined precisely how the IL-18 alleles influence the pathogenesis of IBD.

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IL18 polymorphism is associated with an increased risk of Crohn’s disease

Abstract: IL18 is probably one of several genes that determine susceptibility to Crohn's disease.

Cited by 79 publications

References 29 publications

The IL18 gene and Hashimoto thyroiditis in children

The IL18 gene and Hashimoto thyroiditis in children

A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease

Interleukin-18 Gene Polymorphisms in Tunisian Patients with Inflammatory Bowel Disease

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