Ileal Neuroendocrine Tumor With Bilateral Breast and Ovarian Metastases

Abstract

Metastasis to the breast is a rare occurrence and constitutes less than 2% of all breast tumors. Similarly, ovarian metastases from neuroendocrine tumors are also uncommon, and if the adnexal masses are bilateral, then the chances of it being metastatic rather than being primary range from 88% to 94%. We present a case of 61-year-old woman who in the course of workup for abdominal pain and diarrhea was eventually diagnosed as ileal neuroendocrine tumor with breast, ovarian, and lymph nodal metastases on 68Ga-DOTANOC PET/CT scan.

Bilateral breast metastases as the first manifestation of an occult pancreatic neuroendocrine tumor

“…Although recent data suggests that, probably, breast metastases from NETs are more frequent than what was thought, they remain a rare phenomenon with no more than 200 cases published in literature [8 , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] . The most common primary site of metastatic NET breast lesions is represented by the ileum, followed by appendix, duodenum, pancreas, lung and ovary [8 , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] . With regard to cases of bilateral breast metastases from a distant primary NET, there are less than 15 cases reported in literature and, in particular, to the best of our knowledge, only two cases originating from a pancreatic neuroendocrine tumor (PNET) are reported [8 , 20] .…”