Ileocolonic tuberculosis clinically, endoscopically, and radiologically mimicking Crohn's disease: Disseminated infection after treatment with infliximab

Cappell, Mitchell S.; Saad, Abdulhassan; Bortman, Jared; Amin, Mitual

doi:10.1016/j.crohns.2013.11.022

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…The signs of Johne’s disease in ruminants are similar to the symptoms of CD. Moreover, CD demonstrates a striking similarity of symptoms to intestinal tuberculosis caused by M. tuberculosis , Mtb [ 10 - 12 ].…”

Section: Introductionmentioning

confidence: 99%

The vesicle-associated function of NOD2 as a link between Crohn’s disease and mycobacterial infection

Nabatov

2015

Gut Pathog

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Although Crohn’s disease (CD) etiology remains unclear, a growing body of evidence suggests that CD may include an infectious component, with Mycobacterium avium subsp. paratuberculosis (MAP) being the most likely candidate for this role. However, the molecular mechanism of the MAP involvement in CD pathogenesis remains unclear. The polymorphism of the NOD2 gene, coding for an intracellular pattern recognition receptor, is a factor of predisposition to mycobacterial infections and CD. Recent findings on NOD2 interactions and functions provide the missing pieces in the puzzle of a NOD2-mediated mechanism common for mycobacterial infections and CD. Implications of these new findings for the development of a better understanding and treatments of CD and mycobacterial infections are discussed.

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Section: Introductionmentioning

confidence: 99%

The vesicle-associated function of NOD2 as a link between Crohn’s disease and mycobacterial infection

Nabatov

2015

Gut Pathog

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“…The correct etiological diagnosis of IBD is indispensable for proper therapy (Table 1 ) because unnecessary anti-TB therapy increases the risk of toxicity and multi-drug resistance and delays the treatment of CD, whereas steroids and infliximab (usually used for CD) can accelerate the TB’s dissemination and favor intestinal perforation[ 12 , 33 , 34 , 39 ]. In patients with neurological abnormalities, administration of vitamin B12 can accelerate the evolution of an undiagnosed tumor, which can be responsible for paraneoplastic neuropathy.…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis terminal ileitis: A forgotten entity mimicking Crohn’s disease

Gurzu¹,

Molnar²,

Contac³

et al. 2016

WJCC

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Intestinal tuberculosis (TB) is an uncommon lesion for which differential diagnosis can be difficult. We present a case of a 53-year-old male and a systematic review of the literature, from clinical symptoms to differential diagnosis, unusual complications and therapy. The patient was admitted to the hospital with signs of acute abdomen as a result of a perforated terminal ileitis. Based on the skip lesions of the terminal ileum and cecum, Crohn’s disease (CD) was clinically suspected. An emergency laparotomy and right colectomy with terminal ileum resection was performed and systematic antibiotherapy was prescribed. The patient’s status deteriorated and he died 4 d after the surgical intervention. At the autopsy, TB ileotyphlitis was discovered. The clinical criteria of the differential diagnosis between intestinal TB and CD are not very well established. Despite the large amount of published articles on this subject, only 50 papers present new data regarding intestinal TB. Based on these studies and our experience, we present an update focused on the differential diagnosis and therapy of intestinal TB. We highlight the importance of considering intestinal TB as a differential diagnosis for inflammatory bowel disease. Despite the modern techniques of diagnosis and therapy, the fulminant evolution of TB can still lead to a patient’s death.

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Infliximab

2015

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Ileocolonic tuberculosis clinically, endoscopically, and radiologically mimicking Crohn's disease: Disseminated infection after treatment with infliximab

Cited by 6 publications

References 5 publications

The vesicle-associated function of NOD2 as a link between Crohn’s disease and mycobacterial infection

The vesicle-associated function of NOD2 as a link between Crohn’s disease and mycobacterial infection

Tuberculosis terminal ileitis: A forgotten entity mimicking Crohn’s disease

Infliximab

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