Image blending and speckle noise reduction in multi-beam OCT

Holmes, Jon; Hattersley, Simon

doi:10.1117/12.808575

Cited by 18 publications

(11 citation statements)

References 5 publications

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“…Fourier domain systems can scan tissue more quickly, which is important in clinical use, and deeper tissue can be visualized with better contrast. The commercial system used in this study had additional optical techniques to enhance resolution and contrast compared with standard Fourier domain systems, with an optical lateral resolution of at least 7·5 μm and axial resolution of at least 5 μm.…”

Section: Discussionmentioning

confidence: 99%

The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study

et al. 2015

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has received speaker's honoraria from Almirall Hermal, Biofrontera, Galderma, Meda Pharma and JanssenCilag. C.B. has received speaker's and advisory board member's honoraria from, and has been involved in clinical trials sponsored by Almirall SummaryBackground The diagnostic criteria for basal cell carcinoma (BCC) using optical coherence tomography (OCT) have been described previously, but the clinical value of these findings remains unknown. Objectives To investigate the diagnostic value of OCT for BCC in a typical clinical setting. The primary efficacy end point was a diagnosis of BCC for each lesion. Secondary end points were the diagnosis of other possible conditions. Methods This was an observational, prospective, multicentre study in which consecutive patients with nonpigmented pink lesions suspicious for BCC underwent clinical assessment, dermoscopy and OCT, with the diagnosis recorded at each stage. Once all diagnoses had been recorded, the histological results were disclosed. In total 164 patients with 256 lesions were recruited. Histology was missing for 21 lesions, leaving 235 lesions in 155 patients for analysis. Results Sixty per cent of lesions (141 of 235) were identified as BCC by histology. A slight increase of sensitivity was noted following OCT, which did not reach statistical significance. The specificity increased significantly from 28Á6% by clinical assessment to 54Á3% using dermoscopy and to 75Á3% with the addition of OCT (P < 0Á001). The positive predictive value for the diagnosis of BCC using OCT was 85Á2% [95% confidence interval (CI) 78Á6-90Á4], and the negative predictive value was 92Á1% (95% CI 83Á6-97Á0). The accuracy of diagnosis for all lesions increased from 65Á8% with clinical evaluation to 76Á2% following additional dermoscopy and to 87Á4% with the addition of OCT. Conclusions OCT significantly improved the diagnostic specificity for BCC compared with clinical assessment and dermoscopy alone.

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Section: Discussionmentioning

confidence: 99%

The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study

et al. 2015

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“…Unless dynamic focusing is employed, which is not suitable for high speed imaging, the depth of focus cannot cover the depth of the whole anterior segment. Multiple-channel [23,26] and multiple-focus OCT [35–37] offer possible solutions to the problem.…”

Section: Introductionmentioning

confidence: 99%

Dual channel dual focus optical coherence tomography for imaging accommodation of the eye

Zhou¹,

Wang²,

Jiao³

2009

Opt. Express

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A dual channel dual focus spectral-domain optical coherence tomography was developed for imaging the accommodation of the eye in real time. The system can provide simultaneous cross-sectional imaging of all the surfaces of the anterior segment of the eye including the cornea, anterior chamber, anterior and posterior surfaces of the crystalline lens. Thus, the modification of the curvatures of the anterior and posterior surfaces of the crystalline lens and the dimensions of the anterior segment of the eye with accommodation can be calculated. The system was successfully tested in imaging accommodation. The preliminary results demonstrated the feasibility of this novel approach.

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“…This approach has been implemented using the Gabor-based fusion method 35 . It can also be appplied by focusing several light beams at different depths 36 . The latter approach, implemented in the Vivosight FD-OCT device (Michelson Diagnostics) for skin imaging, yields a lateral resolution of 7 µm 36 .…”

Section: Time-domain and Frequency-domain Octmentioning

confidence: 99%

Advances in optical coherence tomography for dermatology

Levecq

Davis

Azimani

et al. 2018

Unconventional Optical Imaging

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This paper reports on advances in optical coherence tomography (OCT) for application in dermatology. Full-field OCT is a particular approach of OCT based on white-light interference microscopy. FF-OCT produces en face tomographic images by arithmetic combination of interferometric images acquired with an area camera and by illuminating the whole field of view with low-coherence light. The major interest of FF-OCT lies in its high imaging spatial resolution (∼ 1.0 µm) in both lateral and axial directions, using a simple and robust experimental arrangement. Line-field OCT (LF-OCT) is a recent evolution of FF-OCT with line illumination and line detection using a broadband spatially coherent light source and a line-scan camera in an interference microscope. LF-OCT and FF-OCT are similar in terms of spatial resolution. LF-OCT has a significant advantage over FF-OCT in terms of imaging penetration depth due to the confocal gate achieved by line illumination and detection. B-scan imaging using FF-OCT requires the acquisition of a stack of en face images, which usually prevents in vivo applications. B-scan imaging using LF-OCT can be considerably faster due to the possibility of using a spatially coherent light source with much higher brightness along with a high-speed line camera. Applied in the field of dermatology, the LF-OCT images reveal a comprehensive morphological mapping of skin tissues in vivo at a cellular level similar to histological images.

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Image blending and speckle noise reduction in multi-beam OCT

Cited by 18 publications

References 5 publications

The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study

The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of nonpigmented basal cell carcinoma: an observational study

Dual channel dual focus optical coherence tomography for imaging accommodation of the eye

Advances in optical coherence tomography for dermatology

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