Nowadays, data are the most valuable content in the world. In the age of big data, we are generating quintillions of data daily in the form of text, image, video, etc. Among them, images are highly used in daily communications. Various types of images, e.g., medical images, military images, etc. are highly confidential. But, due to data vulnerabilities, transmitting such images in a secured way is a great challenge. For this reason, researchers proposed different image cryptography algorithms. Recently, biological deoxyribonucleic acid (DNA)-based concepts are getting popular for ensuring image security as well as encryption as they show good performance. However, these DNA-based methods have some limitations, e.g., these are not dynamic and their performance results are far from ideal values. Further, these encryption methods usually involve two steps, confusion and diffusion. Confusion increases huge time complexity and needs to send one or more additional map tables with a cipher to decrypt the message. In this research, we propose a novel and efficient DNA-based key scrambling technique for image encryption that addresses the above limitations. We evaluate our proposed method using 15 different datasets and achieved superior performance scores of entropy, keyspace, cipher pixel correlations, variance of histogram, time complexity and PSNR. The experimental results show that our method can be used for image encryption with a high level of confidentiality.