Image formation of brain function in patients suffering from knee osteoarthritis treated with moxibustion

Xie, Hong-Wu; Xu, Fei; Chen, Rixin; Luo, Tianyou; Chen, Ming–Ren; Fang, Weidong; Fj, Lu; Wu, Fei; Song, Yun-E; Xiong, Jun

doi:10.1016/s0254-6272(13)60122-3

Cited by 12 publications

(14 citation statements)

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“…ONFH may lead to intractable pain and the functional disability of the hip joint. Chronic pain and gait abnormality could influence the spatial patterns of intrinsic brain activity (Xie et al, 2013 ; Chen et al, 2015 ; Flodin et al, 2016 ; Ryan et al, 2018 ; Schrepf et al, 2018 ). Our study investigated the ONFH-related changes in the intrinsic or spontaneous brain activity by measuring the ALFF values of resting-state fMRI signals.…”

Section: Discussionmentioning

confidence: 99%

“…A study based on the moxibustion treatment of knee osteoarthritis demonstrated increased fractional amplitude of low-frequency fluctuation (fALFF) values in the bilateral cerebrum, extra-nucleus, left cerebellum, and white matter. Simultaneously, the fALFF values of the precentral gyrus (PreCG), frontal lobe, and occipital lobe were found to be decreased (Xie et al, 2013 ). In rheumatoid arthritis patients, Flodin et al ( 2016 ) reported that the supplementary motor areas, midcingulate cortex, and primary sensorimotor cortex exhibited enhanced functional connectivity.…”

Section: Introductionmentioning

confidence: 99%

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Abnormal Spatial Patterns of Intrinsic Brain Activity in Osteonecrosis of the Femoral Head: A Resting-State Functional Magnetic Resonance Imaging Study

Feng¹,

Li²,

Li³

et al. 2020

Front. Hum. Neurosci.

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Objective: Osteonecrosis of the femoral head (ONFH) is a common condition that is encountered in clinical practice, and yet, little is known about its characteristics and manifestations in the brain. Therefore, in this study, we aimed to use resting-state functional magnetic resonance imaging (rs-fMRI) to investigate the spatial patterns of spontaneous brain activity in the brain of ONFH patients. Methods: The study included ONFH patients and healthy controls. The pattern of intrinsic brain activity was measured by examining the amplitude of low-frequency fluctuations (ALFF) of blood oxygen level-dependent signals using rs-fMRI. Meanwhile, we also used Harris hip scores to evaluate the functional performance of ONFH patients and healthy controls. Result: Ten ONFH patients and 10 health controls were investigated. We found global ALFF differences between the two groups throughout the occipital, parietal, frontal, prefrontal, and temporal cortices. In the ONFH patients, altered brain activity was found in the brain regions in the sensorimotor network, pain-related network, and emotion and cognition network. The results of the correlation investigations also demonstrated that the regions with ALFF changes had significant correlations with the functional performance of the patients evaluated by Harris hip scores.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Abnormal Spatial Patterns of Intrinsic Brain Activity in Osteonecrosis of the Femoral Head: A Resting-State Functional Magnetic Resonance Imaging Study

Feng¹,

Li²,

Li³

et al. 2020

Front. Hum. Neurosci.

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“…Although the exact biologic mechanisms of ALFF are still unclear, it has been widely used in studies for neuropsychological diseases ( 24 – 26 ) due to the fact that altered ALFF is directly related to abnormal regional neuronal activity ( 26 , 27 ). Similar algorithms have been applied to detect the influence of moxibustion on functional brain alterations in patients with KOA between pre- and post-treatment ( 28 ). Thus, ALFF is potentially valuable for uncovering the mechanism underlying the changes in brain function in the older patients with KOA before and after TKA.…”

Section: Discussionmentioning

confidence: 99%

Altered Intrinsic Brain Activity and Functional Connectivity Before and After Knee Arthroplasty in the Elderly: A Resting-State fMRI Study

et al. 2020

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Objective: This study aimed to investigate the brain functional alterations with resting-state functional magnetic resonance imaging (rs-fMRI) in older patients with knee osteoarthritis (KOA) before and after total knee arthroplasty (TKA) and to assess the causal relationship of the brain function and neuropsychological changes. Methods: We performed rs-fMRI to investigate brain function of 23 patients aged ≥65 with KOA and 23 healthy matched controls. Of the KOA patients, 15 completed postoperative rs-fMRI examinations. Analyzes of the amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) were used to estimate differences in brain functional parameters between KOA patients, postoperative patients, and the controls. The relationship between changes of pre- and post-surgical status in ALFF and neuropsychological test results was analyzed. Results: Compared with the controls, all patients with KOA exhibited decreased ALFF in the default mode network (bilateral angular gyrus, precuneus gyrus, medial superior frontal gyrus) and increased ALFF in the bilateral amygdala and cerebellum posterior lobe before surgery ( P < 0.001). Altered ALFF persisted in the same brain regions 1 week postoperatively. The decreased ALFF in the left precuneus gyrus and middle temporal gyrus was found after surgery when compared with preoperative data ( P < 0.01). Preoperatively, the KOA patients exhibited increased FC between the left precuneus gyrus and the right supplementary motor area compared to the controls ( P < 0.001), but this connectivity became no significant difference after TKA. The left Cerebelum_9 was found to have decreased FC with the right precuneus gyrus postoperatively ( P < 0.001) although this was not significantly different before surgery. The significantly altered ALFF values were not correlated with changes in cognitive assessment scores. Conclusion: In older patients with end-stage KOA, functional alterations in important brain regions were detected with the persistence and further changes observed at an early stage after knee replacement. Our data further our understanding of brain functional abnormalities and cognitive impairment in older patients following knee replacement, which may provide therapeutic targets for preventive/treatment strategy to be developed. Trial registration: Clinical Trial Registration: http://www.chictr.org.cn/index.aspx , ChiCTR1800016437; Registered June 1, 2018.

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“…However, the recipient was able to sense the trans-segmental heat in the distant parts. Xie et al [4] used fMRI to study the responses and found that the brain function regulation of heat-sensitization responses did not coordinate through a single brain region but a network composed of multiple brain regions, especially in the prefrontal and island cortices. Liao et al [13] used high-density electroencephalogram (EEG) to test the EEG characteristics of moxibustion-induced heat-sensitization responses.…”

Section: Discussionmentioning

confidence: 99%

“…In our previous studies, most reactions to heat-sensitization moxibustion, which were described by the participants, were observed directly or collaterally relating with neurological system; noticeably the brain perception was spotted [3]. A study of functional magnetic resonance imaging (fMRI) also showed that heat-sensitization response was manifested in the changes of brain activities in prefrontal cortex [4]. Therefore, we hypothesize that neurological system is involved in moxibustion-induced heat-sensitization responses.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Potentiation of Prelimbic Cortex Ascribed to Heat-Sensitization Responses of Moxibustion

Chen¹,

Lyu

Xie³

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Heat-sensitization responses occurred in certain patients while exposed to suspended moxibustion. The response often indicated that the efficacy of moxibustion to those with it tended to triumph over those without. However, its mechanism remains to be explained. Our previous fMRI and EEG studies confirmed the changes of activities in cerebral certain regions accompanied with heat-sensitization responses, especially in prefrontal cortex. Therefore, we hypothesize that neurological system is involved in moxibustion-induced heat-sensitization responses. In the present study, phosphorylation of Cofilin representing long-term potentiation in synapse of prelimbic cortex of medial prefrontal cortex in stroke rats over suspended moxibustion was assessed, and the size of phosphorylated Cofilin positive spine in synapse was also measured. The result showed that heat-sensitization responses were observed to augment cerebral ischemic stroke-induced phosphorylation of Cofilin in prelimbic cortex of rats and increase the numbers of large synapses. This indicated that long-term potentiation of prelimbic cortex was attributed to heat-sensitization responses that were certain neurological responses of medial prefrontal cortex to suspended moxibustion.

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Image formation of brain function in patients suffering from knee osteoarthritis treated with moxibustion

Cited by 12 publications

References 1 publication

Abnormal Spatial Patterns of Intrinsic Brain Activity in Osteonecrosis of the Femoral Head: A Resting-State Functional Magnetic Resonance Imaging Study

Abnormal Spatial Patterns of Intrinsic Brain Activity in Osteonecrosis of the Femoral Head: A Resting-State Functional Magnetic Resonance Imaging Study

Altered Intrinsic Brain Activity and Functional Connectivity Before and After Knee Arthroplasty in the Elderly: A Resting-State fMRI Study

Long-Term Potentiation of Prelimbic Cortex Ascribed to Heat-Sensitization Responses of Moxibustion

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