Image-guided thermosensitive liposomes for focused ultrasound enhanced co-delivery of carboplatin and SN-38 against triple negative breast cancer in mice

Cressey, Paul; Amrahli, Maral; So, Po‐Wah; Gedroyc, Wladyslaw; Wright, Michael; Thanou, Maya

doi:10.1016/j.biomaterials.2021.120758

Cited by 30 publications

(16 citation statements)

References 59 publications

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“…Gadolinium lipid conjugate was incorporated into the lipid bilayer to make the iTSL MRI visible. The authors were able to target the delivery of SN-38 and carboplatin to the tumors in TNBC cancer xenografts using focused ultrasound and achieved dramatic inhibition of tumor growth and longer survival of the mice [ 106 ]. Using a similar system, M. Amrahl et al targeted the delivery of doxorubicin in the tumors of mice engrafted with human TNBC cancer using iTSL-encapsulated doxorubicin and focused ultrasound [ 107 ].…”

Section: Ultrasound-sensitive Micro- and Nanocarriersmentioning

confidence: 99%

Enhancing Targeted Therapy in Breast Cancer by Ultrasound-Responsive Nanocarriers

Edwards

Carlo

Sitta

et al. 2023

IJMS

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Currently, the response to cancer treatments is highly variable, and severe side effects and toxicity are experienced by patients receiving high doses of chemotherapy, such as those diagnosed with triple-negative breast cancer. The main goal of researchers and clinicians is to develop new effective treatments that will be able to specifically target and kill tumor cells by employing the minimum doses of drugs exerting a therapeutic effect. Despite the development of new formulations that overall can increase the drugs’ pharmacokinetics, and that are specifically designed to bind overexpressed molecules on cancer cells and achieve active targeting of the tumor, the desired clinical outcome has not been reached yet. In this review, we will discuss the current classification and standard of care for breast cancer, the application of nanomedicine, and ultrasound-responsive biocompatible carriers (micro/nanobubbles, liposomes, micelles, polymeric nanoparticles, and nanodroplets/nanoemulsions) employed in preclinical studies to target and enhance the delivery of drugs and genes to breast cancer.

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Section: Ultrasound-sensitive Micro- and Nanocarriersmentioning

confidence: 99%

Enhancing Targeted Therapy in Breast Cancer by Ultrasound-Responsive Nanocarriers

Edwards

Carlo

Sitta

et al. 2023

IJMS

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“…TCM formulations which contain two or more herbs can often result in better curative outcomes and fewer adverse effects than formulations with single herbs [ 92 , 93 ]. Studies have shown that co-loaded nanocarrier systems could allow for the encapsulated drugs to exert a synergistic antitumor effect [ 94 , 95 ]. Some studies have reported that the combination of curcumin and TP at low concentrations has a synergistic antitumor effect on ovarian cancer [ 96 ].…”

Section: Tdds For Tpmentioning

confidence: 99%

Delivery of triptolide: a combination of traditional Chinese medicine and nanomedicine

et al. 2022

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As a natural product with various biological activities, triptolide (TP) has been reported in anti-inflammatory, anti-tumor and anti-autoimmune studies. However, the narrow therapeutic window, poor water solubility, and fast metabolism limit its wide clinical application. To reduce its adverse effects and enhance its efficacy, research and design of targeted drug delivery systems (TDDS) based on nanomaterials is one of the most viable strategies at present. This review summarizes the reports and studies of TDDS combined with TP in recent years, including passive and active targeting of drug delivery systems, and specific delivery system strategies such as polymeric micelles, solid lipid nanoparticles, liposomes, and stimulus-responsive polymer nanoparticles. The reviewed literature presented herein indicates that TDDS is a multifunctional and efficient method for the delivery of TP. In addition, the advantages and disadvantages of TDDS are sorted out, aiming to provide reference for the combination of traditional Chinese medicine and advanced nano drug delivery systems (NDDS) in the future. Graphical Abstract

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“…57,58 With the targeted triggered release from polymeric micelles or microbubbles and thermosensitive liposomes, this hyperthermia technique has demonstrated considerable improvements in tumor therapy. [59][60][61] Utilizing the thermal effects of US in drug delivery systems (DDSs) that respond to heat can increase drug concentrations at target sites and improve the effectiveness of therapy.…”

Section: Mechanism Of Ultrasound-induced Drug Deliverymentioning

confidence: 99%

Ultrasound Responsive Smart Implantable Hydrogels for Targeted Delivery of Drugs: Reviewing Current Practices

Sun¹,

Chen²,

Fan³

et al. 2022

IJN

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Over the last two decades, the process of delivering therapeutic drugs to a patient with a controlled release profile has been a significant focus of drug delivery research. Scientists have given tremendous attention to ultrasound-responsive hydrogels for several decades. These smart nanosystems are more applicable than other stimuli-responsive drug delivery vehicles (ie UV-, pH-and thermal-, responsive materials) because they enable more efficient targeted treatment via relatively non-invasive means. Ultrasound (US) is capable of safely transporting energy through opaque and complex media with minimal loss of energy. It is capable of being localized to smaller regions and coupled to systems operating at various time scales. However, the properties enabling the US to propagate effectively in materials also make it very difficult to transform acoustic energy into other forms that may be used. Recent research from a variety of domains has attempted to deal with this issue, proving that ultrasonic effects can be used to control chemical and physical systems with remarkable specificity. By obviating the need for multiple intravenous injections, implantable US responsive hydrogel systems can enhance the quality of life for patients who undergo treatment with a varied dosage regimen. Ideally, the ease of selfdosing in these systems would lead to increased patient compliance with a particular therapy as well. However, excessive literature has been reported based on implanted US responsive hydrogel in various fields, but there is no comprehensive review article showing the strategies to control drug delivery profile. So, this review was aimed at discussing the current strategies for controlling and targeting drug delivery profiles using implantable hydrogel systems.

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Image-guided thermosensitive liposomes for focused ultrasound enhanced co-delivery of carboplatin and SN-38 against triple negative breast cancer in mice

Cited by 30 publications

References 59 publications

Enhancing Targeted Therapy in Breast Cancer by Ultrasound-Responsive Nanocarriers

Enhancing Targeted Therapy in Breast Cancer by Ultrasound-Responsive Nanocarriers

Delivery of triptolide: a combination of traditional Chinese medicine and nanomedicine

Ultrasound Responsive Smart Implantable Hydrogels for Targeted Delivery of Drugs: Reviewing Current Practices

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