Imageable Antigen‐Presenting Gold Nanoparticle Vaccines for Effective Cancer Immunotherapy In Vivo

Lee, In-Hyun; Kwon, Ho-Keun; An, Sukyung; Kim, Daejin; Kim, Sung-Hyun; Yu, Mi; Lee, Jae-Hyuk; Lee, Yong Jin; Im, Sungbin; Jon, Sangyong

doi:10.1002/anie.201203193

Cited by 168 publications

(69 citation statements)

References 45 publications

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“…Studies demonstrated that nanoparticles, such as gold nanoparticles [15, 41, 42], silver nanoparticles [16], gelatin nanoparticles [43] and silica nanoparticles [28, 38], can be used to deliver genes and proteins to targets. Therefore, binding of immunostimulatory CpG ODN onto aminated MSNs will surely enhance the CpG ODN stability.…”

Section: Resultsmentioning

confidence: 99%

Effect of amino groups of mesoporous silica nanoparticles on CpG oligodexynucleotide delivery

Claiden²,

Zhu

et al. 2015

Science and Technology of Advanced Materials

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In this study, we proposed to modify mesoporous silica nanoparticles (MSNs) with 3-aminopropyltriethoxysilane (NH2-TES), aminoethylaminopropyltriethoxysilane (2NH2-TES) and 3-[2-(2-aminoethylamino)ethylamino] propyl-trimethoxysilane (3NH2-TES) for binding of cytosine-phosphate-guanosine oligodexynucleotides (CpG ODN), and investigated the effect of different amino groups of MSNs on the CpG ODN delivery. Serum stability, in vitro cytotoxicity, and cytokine interleukin-6 (IL-6) induction by MSN-NH2/CpG, MSN-2NH2/CpG and MSN-3NH2/CpG complexes were investigated in detail. The results showed that three kinds of aminated-MSN-based CpG ODN delivery systems had no cytotoxicity to RAW264.7 cells, and binding of CpG ODN to MSN-NH2, MSN-2NH2 and MSN-3NH2 nanoparticles enhanced the serum stability of CpG ODN due to protection by the nanoparticles. However, three aminated MSN-based CpG ODN delivery systems exhibited different CpG ODN delivery efficiency, and MSN-NH2/CpG complexes had the highest ability to induce IL-6 secretion.

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Section: Resultsmentioning

confidence: 99%

Effect of amino groups of mesoporous silica nanoparticles on CpG oligodexynucleotide delivery

Claiden²,

Zhu

et al. 2015

Science and Technology of Advanced Materials

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“…In addition, a nanoparticle based approach allows efficient antigen delivery to lymph nodes through lymphatic vessels in a size-dependent manner. Lee et al (46) reported gold nanoparticles (AuNP)-based cancer vaccines to increase immune response for toll-like receptor 9 (TLR-9) activation of DCs. Antigen delivery to lymph nodes can be tracked using computed tomography (CT) imaging.…”

Section: Multifunctional Nanoparticlesmentioning

confidence: 99%

Nanoparticle-Based Vaccine Delivery for Cancer Immunotherapy

et al. 2013

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Development of nano-sized carriers including nanoparticles, nanoemulsions or liposomes holds great potential for advanced delivery systems for cancer immunotherapy, as such nanostructures can be used to more effectively manipulate or deliver immunologically active components to specific target sites. Successful development of nanotechnology based platform in the field of immunotherapy will allow the application of vaccines, adjuvants and immunomodulatory drugs that improve clinical outcomes for immunological diseases. Here, we review current nanoparticle-based platforms in the efficacious delivery of vaccines in cancer immunotherapy.

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“…Upon injection of the resulting 23 nm particles in the rear footpads of mice, their migration to the popliteal and inguinal nodes could be followed with CT scans [57] . To date however, not many research groups have reported on such multimodal particulate vaccines yet.…”

Section: Multifaceted Antigen-delivery Vehiclesmentioning

confidence: 99%

Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment

et al. 2014

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Over the years research in the field of cancer immunotherapy has flourished, bringing about crucial breakthroughs, but at the same time revealing new and important pathways of immune suppression that put a break on the success of cancer immunotherapy. This review focuses on how nano-and micromaterials can be used to induce antitumor immune responses and what their role in overcoming immune suppression could be. It is now beyond question that this requires elegantly designed particles that can reach their target cells, deliver antigenic cargo and most importantly immune stimulants in order to provoke and sustain antitumor immunity.3

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Imageable Antigen‐Presenting Gold Nanoparticle Vaccines for Effective Cancer Immunotherapy In Vivo

Cited by 168 publications

References 45 publications

Effect of amino groups of mesoporous silica nanoparticles on CpG oligodexynucleotide delivery

Effect of amino groups of mesoporous silica nanoparticles on CpG oligodexynucleotide delivery

Nanoparticle-Based Vaccine Delivery for Cancer Immunotherapy

Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment

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