Images in Pathology

Solitary pulmonary adenofibroma in a middle-aged man with bladder cancer

“…Histological description of the lesion was consistent in the literature with the epithelial constituent being composed of complex glands lined by simple cuboidal to columnar epithelium that did not show evidence of necrosis,[ 7 8 9 10 11 12 13 14 15 ] and the stromal constituent being composed of bland spindle cell fibroblastic proliferation.…”

“…The clinical presentation in the review of the literature was variable, ranging from asymptomatic incidental finding,[ 3 4 5 6 ] to chest pain,[ 1 2 7 8 9 10 11 12 13 14 15 16 ] cough,[ 8 ] and hemoptysis. [ 2 8 ] It has been reported in both genders with no obvious gender predilection.…”

Pulmonary adenofibroma in a sika deer

“…Pulmonary adenofibromas are benign lesions affecting the lung parenchyma, and they are characteristically composed of complex epithelial and stromal components [1,2,3,4,5,6, 8,9,10,11,12]. As for the pathogenesis of pulmonary adenofibromas, it remains unclear whether these lesions are hamartomas or true neoplasms.…”

“…It was first described in 1944 [8], and few cases have been reported so far [1,2,3,4,5,6, 9,10,11,12]. Pulmonary adenofibromas usually occur as single well-demarcated nodules, ranging in size from 0.5 to 9.5 cm (mean maximum dimension: 2.9 cm), in the lung parenchyma [1,2,3,4, 6, 8,9,10,11,12]. One patient was reported to have 10 pulmonary adenofibromas, which ranged in size from 0.2 to 1.5 cm [5].…”

“…One patient was reported to have 10 pulmonary adenofibromas, which ranged in size from 0.2 to 1.5 cm [5]. Histologically, pulmonary adenofibromas are biphasic lesions composed of epithelial and stromal components, and they exhibit a characteristic leaf-like/”phyllodes-like” growth pattern [1,2,3,4,5,6, 8,9,10,11,12]. The stromal components of pulmonary adenofibromas contain multiple, club-shaped papillary projections, which result in staghorn-like slit-shaped spaces lined by simple cuboidal to columnar epithelia [1,2,3,4,5,6, 8,9,10,11,12].…”