Imaging alveolar–capillary gas transfer using hyperpolarized
            <sup>129</sup>
            Xe MRI

Driehuys, Bastiaan; Cofer, Gary P.; Pollaro, Jim; Mackel, Julie B.; Hedlund, Laurence W.; Johnson, G. Allan

doi:10.1073/pnas.0608458103

Cited by 223 publications

(247 citation statements)

References 25 publications

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“…Similar results were also obtained in dogs (39). Recently Driehuys et al (40) applied hyperpolarized 129 Xe MRI to a rat model of unilateral BLM lung injury. The 129 Xe signal is detectable in the gas phase (airspace compartment) and once the gas is absorbed into the tissue and red blood cells.…”

Section: Discussionsupporting

confidence: 64%

Bleomycin‐induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI

Karmouty‐Quintana

Cannet

Zurbruegg

et al. 2007

Magnetic Resonance Imaging

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Purpose:To apply proton magnetic resonance imaging (MRI) techniques to assess noninvasively and in spontaneously breathing rats, structural changes following a single intratracheal administration of bleomycin (BLM). Materials and Methods:Rats were scanned by MRI prior to BLM or vehicle administration and at six hours, 24 hours, week 1, and at weeks 2, 3, 6, and 8 after treatment. Bronchoalveolar lavage (BAL) fluid and histological analyses were performed at 24 hours, and at weeks 1 and 8 (histology only).Results: Prominent MRI fluid signals were detected in the lungs of BLM-treated rats one week after challenge. These signals correlated with increased inflammatory parameters in BAL fluid and with marked perivascular and parenchymal infiltration with inflammatory cells in histological slices. At week 2 the MRI signals due to edema resolved, but nevertheless an increase in MRI signal intensity from the lung parenchyma was apparent. In some areas of the right lung the MRI signal intensity in the parenchyma decreased between weeks 2 and 8. These observations were in line with histology demonstrating collagen deposition and atelectasis (hallmarks of fibrosis) at week 1 and a partial recovery of the lung parenchyma at week 8. Conclusion:The data demonstrate the ability of proton MRI to detect BLM-induced lung fibrosis as well as the acute inflammatory response caused by the agent.

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Section: Discussionsupporting

confidence: 64%

Bleomycin‐induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI

Karmouty‐Quintana

Cannet

Zurbruegg

et al. 2007

Magnetic Resonance Imaging

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“…spin hyperpolarization | targeted imaging W hen referring to xenon magnetic resonance imaging (MRI), the best-known application is the use of the isotope 129 Xe for facilitating the direct visualization of the airspaces and function of the lung (1)(2)(3)(4). However, in the past few years, the scope for using 129 Xe for targeted biosensor imaging has notably increased (5).…”

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confidence: 99%

Development of an antibody-based, modular biosensor for¹²⁹Xe NMR molecular imaging of cells at nanomolar concentrations

Rose

Witte

Rossella

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

106

120

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Significance The field of xenon magnetic resonance imaging (MRI) is moving closer to the development of targeted xenon biosensors for in vivo applications. It is motivated by a ca. 10 8 -fold improved sensitivity compared with conventional proton MRI. This has been enabled by significant improvements to hardware (xenon polarizer design) and sensitivity (through the hyperpolarized 129 Xe chemical exchange saturation transfer technique). In this paper, we capitalize on these improvements by demonstrating targeted xenon imaging on cells using a modular xenon biosensor. With this method, we can detect target cells with as little as 20 nM of our xenon contrast agent. Imaging of such low levels of cell-specific xenon hosts is unprecedented and reinforces the potential of xenon–cryptophane biosensors for molecular imaging applications.

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“…In particular, xenon's relatively high solubility in biological tissues (2), along with its exquisite sensitivity to its environment that results in an enormous range of chemical shifts upon solution (3), make hyperpolarized Xe129 particularly attractive for exploring certain characteristics of lung function, such as gas exchange and uptake (4,5), not accessible with the use of hyperpolarized He3. Upon inhalation, Xe129 gives rise to multiple MRI spectral peaks in the lung (6)(7)(8)(9), each associated with a physically different compartment.…”

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confidence: 99%

Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129

Mugler

Altes

Ruset

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

188

216

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Despite a myriad of technical advances in medical imaging, as well as the growing need to address the global impact of pulmonary diseases, such as asthma and chronic obstructive pulmonary disease, on health and quality of life, it remains challenging to obtain in vivo regional depiction and quantification of the most basic physiological functions of the lung-gas delivery to the airspaces and gas uptake by the lung parenchyma and blood-in a manner suitable for routine application in humans. We report a method based on MRI of hyperpolarized xenon-129 that permits simultaneous observation of the 3D distributions of ventilation (gas delivery) and gas uptake, as well as quantification of regional gas uptake based on the associated ventilation. Subjects with lung disease showed variations in gas uptake that differed from those in ventilation in many regions, suggesting that gas uptake as measured by this technique reflects such features as underlying pathological alterations of lung tissue or of local blood flow. Furthermore, the ratio of the signal associated with gas uptake to that associated with ventilation was substantially altered in subjects with lung disease compared with healthy subjects. This MRI-based method provides a way to quantify relationships among gas delivery, exchange, and transport, and appears to have significant potential to provide more insight into lung disease.gas exchange | pulmonary function | pulmonary ventilation

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Imaging alveolar–capillary gas transfer using hyperpolarized ¹²⁹ Xe MRI

Cited by 223 publications

References 25 publications

Bleomycin‐induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI

Bleomycin‐induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI

Development of an antibody-based, modular biosensor for¹²⁹Xe NMR molecular imaging of cells at nanomolar concentrations

Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129

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Imaging alveolar–capillary gas transfer using hyperpolarized 129 Xe MRI

Cited by 223 publications

References 25 publications

Bleomycin‐induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI

Bleomycin‐induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI

Development of an antibody-based, modular biosensor for129Xe NMR molecular imaging of cells at nanomolar concentrations

Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129

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Imaging alveolar–capillary gas transfer using hyperpolarized ¹²⁹ Xe MRI

Development of an antibody-based, modular biosensor for¹²⁹Xe NMR molecular imaging of cells at nanomolar concentrations