Imaging Approaches to the Correlation of Structure and Function in the Kidney

Hare, C

doi:10.1159/000020546

Cited by 1 publication

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References 24 publications

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“…MRI is establishing its role as a modality complementary to CT and ultrasonography in the evaluation of kidney [Gilfeather and Woodward, 1998;Hare, 1998;Knesplova and Krestin, 1998]. InT1-weighted images, the renal cortex appears with a higher intensity than the medulla but with a lower intensity than the perineal adipose tissue and the hilus on MRI.…”

Section: Evaluation Of Renal Morphology and Function Using Mrimentioning

confidence: 99%

Partial unilateral ureteral obstruction in rats

Wen

2002

Neurourology and Urodynamics

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This review comprises an overview of the current knowledge on experimental partial unilateral ureteral obstruction (PUUO) and a summary of our latest original experimental PUUO studies in rats. Neonatal PUUO is the type of obstruction that is most often encountered in pediatric clinical practice. However, the pathogenesis of PUUO is still incompletely understood. Most of our knowledge on PUUO has been derived from experimental studies in a variety of animal models. Although progress has been made, the natural history of congenital hydronephrosis is still incompletely described. The effects on kidney functions of long-term urinary tract obstruction, especially PUUO, have been less intensively studied. Recently, we created models with mild and severe PUUO in young rats by embedding the upper one fourth or the upper two thirds of the left ureter into the psoas muscle, respectively. Thereafter, the technique was used to create mild and severe PUUO in newborn rats and magnetic resonance imaging studies showed that both mild and severe obstruction caused a time-dependent decrease in renal blood flow. Compensatory increase in total kidney volume and renal vein blood flow in contralateral non-obstructed kidneys was not detectable when functional deterioration in the partially obstructed kidneys was present. Finally, we investigated the dynamic changes in renal relative signal intensity (RSI) of gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) using magnetic resonance imaging in rats with partial, complete unilateral ureteral obstruction and sham-operated controls. The results showed that changes in Gd-DTPA RSI are compatible with the known physiological and anatomical changes in kidneys in response to ureteral obstruction and useful for distinguishing an obstructed from a non-obstructed collecting system and also for differentiating a partially obstructed from a completely obstructed collecting system.

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Section: Evaluation Of Renal Morphology and Function Using Mrimentioning

confidence: 99%

Partial unilateral ureteral obstruction in rats

Wen

2002

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

Imaging Approaches to the Correlation of Structure and Function in the Kidney

Cited by 1 publication

References 24 publications

Partial unilateral ureteral obstruction in rats

Partial unilateral ureteral obstruction in rats

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