Imaging Bone Metastases in Breast Cancer: Staging and Response Assessment

Cook, Gary; Azad, Gurdip Kaur; Goh, Vicky

doi:10.2967/jnumed.115.157867

Cited by 95 publications

(85 citation statements)

References 68 publications

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“…Tc-MDP in HCC sign has also been reported in patient with cirrhosis, and hepatorenal syndrome has been reported as its probable cause [5][6][7][8][9][10]. In the present case report we present two cases of HCC in the background of chronic liver parenchymal disease with normal renal function tests, in which kidneys were hot on bone scans due to high renal parenchymal retention.…”

Section: Renal Parenchymal Retention Of 99mmentioning

confidence: 78%

“…Incidence of hepatocellular carcinoma (HCC) is on rise in Pakistan because of high incidence of hepatitis C. Its mortality is very high and in spite of well established surveillance programs in patients with chronic liver disease, most tumors are diagnosed in intermediate to advanced stage [3,4]. Pattern of distribution of metastases from HCC has also changed, and skeletal metastases from HCC are now more frequently being observed than mentioned in text books [4,5]. In bone scan performed after 03 hours after i/v injection of 99m Tc-MDP, kidneys are usually faintly visualized in nuclear medicine practice.…”

Section: Introductionmentioning

confidence: 99%

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Increased renal parenchymal retention of 99mTc-MDP (hot kidneys) in two patients of Hepatocellular Cancer: one with and other without osseous metastases

Afzal¹,

Imran²,

Akhtar³

et al. 2017

EJMCR

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Section: Renal Parenchymal Retention Of 99mmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Increased renal parenchymal retention of 99mTc-MDP (hot kidneys) in two patients of Hepatocellular Cancer: one with and other without osseous metastases

Afzal¹,

Imran²,

Akhtar³

et al. 2017

EJMCR

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“…Although a comprehensive analysis of response evaluation by 18 F-FDG PET/CT in patients with metastatic breast cancer is discussed in a separate article in this issue (70), a few concepts are worth noting here.…”

Section: Potential Of Molecular Imaging For Monitoring Disease Responmentioning

confidence: 99%

Molecular Imaging of Biomarkers in Breast Cancer

et al. 2016

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The success of breast cancer therapy is ultimately defined by clinical endpoints such as survival. It is valuable to have biomarkers that can predict the most efficacious therapies or measure response to therapy early in the course of treatment. Molecular imaging has a promising role in complementing and overcoming some of the limitations of traditional biomarkers by providing the ability to perform noninvasive, repeatable whole-body assessments. The potential advantages of imaging biomarkers are obvious and initial clinical studies have been promising, but proof of clinical utility still requires prospective multicenter clinical trials.

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“…However, data on comparisons of these methods with PET methods to determine the best technique for current clinical practice or for clinical trials are insufficient. There are early data supporting the use 18F-FDG PET/MRI (include diffusion weighted imaging) to assess malignant disease in the skeleton, with the possibility of taking advantage of the synergies offered by combining morphologic, physiologic and metabolic imaging 34,35 .…”

Section: Comparison With Hybrid Systems Using Petmentioning

confidence: 99%

“…The greatest benefit of SPECT/CT is reported, however, for these localizations 24 . The authors drew attention to the lower availability and higher cost of PET/CT versus SPECT/CT for a routine check-up 34 . Jambor 35 and Hahn 37 reported about a slight increase in the proportion of indeterminate lesions on the PET/CT scans for the detection of bone metastases in high risk breast cancer patients.…”

Section: Comparison With Hybrid Systems Using Petmentioning

confidence: 99%

SPECT/CT imaging in breast cancer - current status and challenges

Simanek

Koranda²

2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. The increasing incidence of breast cancer worldwide raises the importance of improving imaging techniques for disease stratification after early lesion detection. SPECT/CT imaging is now widely available but its diagnostic potential is not fully utilized for more specific purposes including breast cancer patient stratification. Methods and Results. A Pubmed search for both original and review articles related to the value of SPECT/CT in breast cancer patients and comparison to other diagnostic methods. 62 articles were found using the key words SPECT/CT, Fusion Image and Breast Cancer. Development of a new generation of SPECT/CT systems and their introduction into practice has changed the old diagnostic algorithm. The increasing importance of SPECT/CT in the detection of bone metastases is confirmed. The diagnostic accuracy of new SPECT/CT instruments in the diagnostics of bone metastases is nearly comparable to PET/CT scans. SPECT/CT is more widely available and costs less than PET. It is able not only to identify a sentinel lymph nodes in atypical localizations but also to detect sentinel lymph nodes non visualized on previous planar scans. SPECT/CT offers precise anatomic localization of sentinel lymph nodes, thereby facilitating surgery. Knowledge of precise sentinel lymph node localization can also be applied in radiotherapy. Conclusions. The role of hybrid SPECT/CT imaging in breast cancer patients is changing. It is a powerful modality for skeletal and nodal staging in breast cancer patients with important impact on therapy.

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Imaging Bone Metastases in Breast Cancer: Staging and Response Assessment

Cited by 95 publications

References 68 publications

Increased renal parenchymal retention of 99mTc-MDP (hot kidneys) in two patients of Hepatocellular Cancer: one with and other without osseous metastases

Increased renal parenchymal retention of 99mTc-MDP (hot kidneys) in two patients of Hepatocellular Cancer: one with and other without osseous metastases

Molecular Imaging of Biomarkers in Breast Cancer

SPECT/CT imaging in breast cancer - current status and challenges

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