Imaging Characteristics for Predicting Cognitive Impairment in Patients With Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Taniguchi, Akira; Shindo, Akihiro; Tabei, Ken-ichi; Onodera, Osamu; Ando, Yukio; Urabe, Takao; Kimura, Kazumi; Kitagawa, Kazuo; Miyamoto, Yoshihiro; Takegami, Misa; Ihara, Masafumi; Mizuta, Ikuko; Mizuno, Toshiki; Tomimoto, Hidekazu

doi:10.3389/fnagi.2022.876437

Cited by 5 publications

(4 citation statements)

References 35 publications

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“…130 Severe periventricular and deep white matter lesions were associated with dementia in a study of CADASIL patients from Japan. 131 Our study indicates that pathophysiology and CADASIL are current emerging hot research directions. Research advances during the burst period were elaborated, which will help researchers follow the latest research trends and better plan their future research.…”

Section: Dovepressmentioning

confidence: 76%

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Bibliometric Analysis of Research on Migraine-Stroke Association from 2013 to 2023

Zhang,

Zhou

et al. 2023

JPR

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Background Both migraine and stroke heavily burden individuals, health systems, and society. The migraine-stroke association is of concern and has been studied widely. Our objective is to explore and overview the current research status and emerging trends. Materials and Methods Studies on migraine-stroke association from January 2013 to May 2023 were retrieved and screened from the Web of Science Core Collection (WOSCC) database. Records fulfilling the selection criteria were downloaded and imported into CiteSpace for data mining and visualization. Results A total of 862 papers on migraine-stroke association were included. Annual publications grew slowly. The United States and European countries dominated research in this area. Harvard University published the largest number of articles, while the University of London was most active with other institutions. Ayata Cenk contributed the most articles, while KURTH T and NEUROLOGY were co-cited most. Research hotspots included migraine with aura, ischemic stroke, patent foramen ovale, cortical spreading depolarization, meta-analysis, cross-sectional study, and risk factors. Pathophysiology and small vessel disease represented research frontiers and emerging trends. Conclusion Our study scientifically outlines the migraine-stroke association over the past decade, presenting useful information.

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Section: Dovepressmentioning

confidence: 76%

“… 130 Severe periventricular and deep white matter lesions were associated with dementia in a study of CADASIL patients from Japan. 131 …”

Section: Discussionmentioning

confidence: 99%

Bibliometric Analysis of Research on Migraine-Stroke Association from 2013 to 2023

Zhang,

Zhou

et al. 2023

JPR

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“… 21 , 23 For other scales, such as the Fazekas scale whose maximal score is reached in more than half of patients with CADASIL, a ceiling effect was observed due to the early emergence of extensive WMH. 19 , 20 , 27 Finally, the assessment of specific CADASIL imaging features such as WMH in the anterior temporal lobes has never been considered.…”

Section: Introductionmentioning

confidence: 99%

The CADA-MRIT

Zhang,

Chen,

Tezenas Du Montcel

et al. 2023

Neurology

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Background and objectives:Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and leukoencephalopathy (CADASIL) is the most frequent genetic cerebrovascular disease. The clinical aspects of the disease in relation to the various types of lesions on MRI vary widely within families but also between different cohorts reported worldwide. Many limitations prevent comparison of imaging data obtained with different scanners and sequences in different patients cohorts. We aimed to develop and validate a simple tool to inventory quickly the key MRI features in CADASIL to compare imaging data across different populations.Methods:The Inventory Tool (CADA-MRIT) was designed by consensus after repeated expert meetings. It consisted of eleven imaging items to assess periventricular, deep, and superficial white matter hyperintensity (WMH), lacunes, cerebral microbleeds (CMB), centrum semiovale and basal ganglia dilated perivascular spaces (dPVS), superficial and deep atrophy, large infarcts, and macrobleeds. The reliability, clinical relevance, and time-effectiveness of CADA-MRIT were assessed using data from three independent patient cohorts.Results:Imaging data from 671 CADASIL patients (440 from France, 119 from Germany and 112 from Taiwan) were analyzed. Their mean age was 53.4 ± 12.2 years, 54.5% were women, 56.2% had stroke, and 31.1% had migraine with aura. Any lacune was present in at least 70% of individuals, whereas CMB occurred in 83% of patients from the Asian cohort and in only 35% of European patients. CADA-MRIT scores obtained for WMH, CMB and dPVS were comparable regardless of the scanner or sequence used (weighted κ > 0.60). Intrarater and interrater agreements were good to very good (weighted κ > 0.60). Global WMH and atrophy scores correlated strongly with accurate volumetric quantification of WMH or brain parenchymal fraction (Pearson r > 0.60). Different imaging scores were significantly associated with the main clinical manifestations of the disease. The time for evaluating one patient was around 2-3 minutes.Discussion:The CADA-MRIT is an easy-to-use tool for analyzing and comparing the most frequent MRI lesions of CADASIL across different populations. This instrument is reliable. It can be used with different imaging sequences or scanners. It also provides clinically relevant scores in a very short time for completion.

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“…In addition, an increase of lobar MBs are associated with cognitive decline ( Gregoire et al, 2013 ; Poels et al, 2012 ), and the number of lobar MBs become the predictor for cognitive decline ( Gyanwali et al, 2021 ). Imaging markers for ischemic and hemorrhagic stroke, as well as SVD markers, can predict dementia in patients with stroke ( Rost et al, 2022 ; Taniguchi et al, 2022 ), there are a few reports that SVD markers can be a predictor of cognitive decline in non-stroke patients prospectively.…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging and neuropsychological findings for predicting of cognitive deterioration in memory clinic patients

Matsumoto

Shinohara

et al. 2023

Front. Aging Neurosci.

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ObjectiveThe severity of cerebral small vessel disease (SVD) on magnetic resonance imaging (MRI) has been assessed using hypertensive arteriopathy SVD and cerebral amyloid angiopathy (CAA)-SVD scores. In addition, we reported the modified CAA-SVD score including cortical microinfarcts and posterior dominant white matter hyperintensity. Each SVD score has been associated with cognitive function, but the longitudinal changes remain unclear. Therefore, this study prospectively examined the prognostic value of each SVD score, imaging findings of cerebral SVD, and neuropsychological assessment.MethodsThis study included 29 patients diagnosed with mild cognitive impairment or mild dementia at memory clinic in our hospital, who underwent clinical dementia rating (CDR) and brain MRI (3D-fluid attenuated inversion recovery, 3D-double inversion recovery, and susceptibility-weighted imaging) at baseline and 1 year later. Each SVD score and neuropsychological tests including the Mini-Mental State Examination, Japanese Raven’s Colored Progressive Matrices, Trail Making Test -A/-B, and the Rivermead Behavioral Memory Test were evaluated at baseline and 1 year later.ResultsTwenty patients had unchanged CDR (group A), while nine patients had worsened CDR (group B) after 1 year. At baseline, there was no significant difference in each SVD score; after 1 year, group B had significantly increased CAA-SVD and modified CAA-SVD scores. Group B also showed a significantly higher number of lobar microbleeds than group A at baseline. Furthermore, group B had significantly longer Japanese Raven’s Colored Progressive Matrices and Trail Making test-A times at baseline. After 1 year, group B had significantly lower Mini-Mental State Examination, Japanese Raven’s Colored Progressive Matrices, and Rivermead Behavioral Memory Test scores and significantly fewer word fluency (letters).ConclusionPatients with worsened CDR 1 year after had a higher number of lobar microbleeds and prolonged psychomotor speed at baseline. These findings may become predictors of cognitive deterioration in patients who visit memory clinics.

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Imaging Characteristics for Predicting Cognitive Impairment in Patients With Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Cited by 5 publications

References 35 publications

Bibliometric Analysis of Research on Migraine-Stroke Association from 2013 to 2023

Bibliometric Analysis of Research on Migraine-Stroke Association from 2013 to 2023

The CADA-MRIT

Magnetic resonance imaging and neuropsychological findings for predicting of cognitive deterioration in memory clinic patients

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