Imaging features of pancreatic metastases: A comparison with pancreatic ductal adenocarcinoma

Galia, Massimo; Albano, Domenico; Picone, Dario; Terranova, Maria Chiara; Agrusa, Antonino; Buono, Giuseppe Di; Licata, A.; Re, Giuseppe Lo; Grutta, Ludovico La; Midiri, Massimo

doi:10.1016/j.clinimag.2018.01.016

Cited by 12 publications

(15 citation statements)

References 31 publications

(43 reference statements)

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“…We collected preoperative data; all patients eligible for inclusion underwent a complete clinical study [5] in order to evaluate their performance status and American Society of Anesthesiology (ASA) score. In all cases, we performed a colonoscopy for the diagnosis and a computed tomography contrast-enhanced abdominal scan for tumoral staging [6,7]. Inclusion criteria were age ≥18 years, right-sided colon cancer, no distant metastasis, and written informed consent.…”

Section: Preoperative Datamentioning

confidence: 99%

Feasibility and Safety of Laparoscopic Complete Mesocolic Excision (CME) for Right-sided Colon Cancer

et al. 2020

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The aim of this prospective clinical study is compare short-term outcome of laparoscopic right hemicolectomy using the Complete Mesocolic Excision (CME group) with patients who underwent conventional right-sided colonic resection (NCME group). Summary Background Data: Although CME with central vascular ligation in laparoscopic righthemicolectomy is associated with a significant decrease in local recurrence rates and improvements in cancerrelated 5-year survival, there may be additional risks associated with this technique because of increased surgical complications. As a result, there is controversy surrounding its use. Methods:In this randomized controlled trial, several primary endpoints (operative time, intraoperative blood loss, other complications, conversion rate, and anastomotic leak) and secondary endpoints (overall postoperative complications) were evaluated. In addition, we evaluated histopathologic data, including specimen length and the number of lymph nodes harvested, as objective signs of the quality of CME, related to oncological outcomes. Results:The CME group had a significantly longer mean operative time than the NCME group (216.3 min versus 191.5 min, p=0.005). However, the CME group had a higher number of lymph nodes (23.8 versus 16.6; p<0.001) and larger surgical specimens (34.3 cm versus 29.3 cm; p=0002). No differences were reported with respect to intraoperative blood loss, conversion rate, leakage, or other postoperative complications. Conclusions:In this study laparoscopic CME were a safe and feasible technique with improvement in lymph nodes harvesting and length of surgical specimens with no increase of surgical intraoperative and postoperative complications.

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Section: Preoperative Datamentioning

confidence: 99%

Feasibility and Safety of Laparoscopic Complete Mesocolic Excision (CME) for Right-sided Colon Cancer

et al. 2020

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“…[1,2] Computed tomography (CT) and magnetic resonance imaging (MRI) describe PNETs as highly vascularized and constrained solid masses. [2] On the other hand, pancreatic ductal adenocarcinomas (PDACs) constitute 95% of the total exocrine pancreatic cancers, [3] which are characterized by hypovascularity in CT or MRI. Differential diagnosis of PNETs and PDACs is usually easy due to the differences in tumor margin, vascularization pattern, pancreatic duct dilatation, and pancreatic atrophy among the tumors.…”

Section: Introductionmentioning

confidence: 99%

Differentiating pancreatic neuroendocrine tumors from pancreatic ductal adenocarcinomas by the “Duct-Road Sign”

Xiao

Zhi

et al. 2019

Medicine

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To assess the duct-road sign and tumor-to-duct ratio (TDR) in MRI for differentiating pancreatic neuroendocrine tumors (PNETs) from pancreatic ductal-adenocarcinomas (PDACs).Retrospectively reviewed MRI characteristics of 78 pancreatic masses (histopathology-proven 25 PNETs and 53 PDACs). Receiver operating characteristics with TDR and diagnostic performance of the duct-road sign for differential diagnosis were performed.The prevalence of duct-road sign in PNETs was higher than that for PDACs (84% vs 0%; P < .001). A strong correlation (r = 0.884, P < .001) was observed between MRI for PNETs and the frequency of this sign. Performance characteristics of the duct-road sign in MRI for PNET diagnosis were sensitivity (84%, [21 of 25]), specificity (100%, [53 of 53]), positive predictive value (100%, [21 of 21]), negative predictive value (92.9%, [53 of 57]), and accuracy (94.8%, [74 of 78]). In the intention-to-diagnose analysis, the corresponding values were 67.7% (21 of 31), 100% (53 of 53), 100% (21 of 21), 84.1% (53 of 63), and 88.1% (74 of 84). The TDR in PNETs was observed to be greater than that in PDACs (14.6 ± 9.3 vs 6.9 ± 3.8, P = .001). TDR with a cut-off value of 7.7 had high sensitivity (84%) and specificity (66%) with area under curve (0.802, 95% CI: 0.699, 0.904; P < .001) for distinguishing PNETs from PDACs.The presence of duct-road sign and TDR > 7.7 on MRI may assist in diagnosis for PNET instead of PDAC.

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“…Acinar cell carcinoma (ACC) is an extremely rare pancreatic tumor comprising 1%‐2% of pancreatic tumors with 50% of tumors presenting with metastases at the time of diagnosis and those patients with advanced disease (Stage III and IV) having very poor prognosis . Cross‐sectional imaging modalities such as computed tomography and magnetic resonance imaging that are enhanced with contrast agents are often utilized to define the extent of primary lesions and possible metastatic disease . An estimated 10%‐15% of ACC’s manifest the neoplastic exocrine disorder termed LHS, and typically, this occurs at an advanced stage with most patients having concurrent metastatic disease to the liver .…”

Section: Discussionmentioning

confidence: 99%

Lipase hypersecretion syndrome: A rare cutaneous manifestation of advanced pancreatic acinar cell carcinoma

Nizam

Shah

Rajack

et al. 2020

Clinical Case Reports

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Imaging features of pancreatic metastases: A comparison with pancreatic ductal adenocarcinoma

Abstract: Imaging features might be helpful to differentiate PM from PDAC.

Cited by 12 publications

References 31 publications

Feasibility and Safety of Laparoscopic Complete Mesocolic Excision (CME) for Right-sided Colon Cancer

Feasibility and Safety of Laparoscopic Complete Mesocolic Excision (CME) for Right-sided Colon Cancer

Differentiating pancreatic neuroendocrine tumors from pancreatic ductal adenocarcinomas by the “Duct-Road Sign”

Lipase hypersecretion syndrome: A rare cutaneous manifestation of advanced pancreatic acinar cell carcinoma

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