Imaging features of retroperitoneal extra‐adrenal paragangliomas in 10 dogs

Gombert, Alexis; Diana, Alessia; Hecht, Silke; Nicoli, Stefano; Fracassi, Federico; Mortier, Jérémy; Reyes-Gomez, Édouard; Pey, Pascaline

doi:10.1111/vru.13063

Cited by 3 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 ). In addition, the mass around the celiac and cranial mesenteric arteries was consistent with a previous report of paraganglioma ( Gombert et al , 2022 ) ( Fig. 1 ).…”

Section: Case Detailssupporting

confidence: 91%

Successful treatment of acute respiratory failure following hypertensive crisis in a dog with presumed pheochromocytoma or paraganglioma

Tamura,

Yoshida,

Nagata

et al. 2023

Open Vet J

View full text Add to dashboard Cite

Background: Acute respiratory failure has been reported one of the manifestations of hypertensive crisis in pheochromocytoma in human medicine. In dogs, no reports have been described acute respiratory failure following hypertensive crisis. Here, we report the clinical presentation, course, and treatment of acute respiratory failure following hypertensive crisis in a dog with presumed pheochromocytoma or paraganglioma. Case Description: A 12-year-old neutered male toy poodle was referred for the diagnostic evaluation of a right adrenal gland mass. The dog suddenly exhibited severe dyspnea with abnormal hypertension (systolic blood pressure > 200 mmHg) 15 minutes after recovery from the anesthesia for the computed tomography (CT) examination. Pulmonary CT and ultrasonography findings suggested acute onset of severe pulmonary edema. Pulmonary edema was treated with mechanical ventilation (pressure-support ventilation with continuous positive airway pressure) and negative fluid balance after the administration of furosemide. Weaning from mechanical ventilation was successful 24 hours after the onset of respiratory failure. Finally, the dog was discharged 3 days after weaning from ventilation without complications. Conclusion: This report outlines a case of acute respiratory failure following a hypertensive crisis requiring mechanical ventilatory management in a dog. The onset and progression of pulmonary edema were extremely rapid. However, improvement in pulmonary edema was also rapid. Hemodynamic stability, in addition to prompt diagnosis and aggressive therapeutic intervention, including mechanical ventilation, may have contributed to the good prognosis of pulmonary edema following hypertensive crisis in a dog, which we attribute to a catecholamine storm.

show abstract

“…1 ). In addition, the mass around the celiac and cranial mesenteric arteries was consistent with a previous report of paraganglioma ( Gombert et al , 2022 ) ( Fig. 1 ).…”

Section: Case Detailssupporting

confidence: 91%

Successful treatment of acute respiratory failure following hypertensive crisis in a dog with presumed pheochromocytoma or paraganglioma

Tamura,

Yoshida,

Nagata

et al. 2023

Open Vet J

View full text Add to dashboard Cite

show abstract

“…In a report of retroperitoneal paragangliomas in dogs, two cases had symptoms of hypertensive crisis (Gombert et al . 2022), but did not meet the diagnostic criteria for pheochromocytoma. The urinary normetanephrine to creatinine ratio in the present case was sufficiently high (21,420 – preoperatively) compared to reports of functional adrenal pheochromocytoma in dogs (Quante et al .…”

Section: Discussionmentioning

confidence: 99%

Intraoperative hypertensive crisis in a dog with functional paraganglioma of the gall bladder

Horikirizono

Nakaichi

Itoh

et al. 2023

J of Small Animal Practice

View full text Add to dashboard Cite

A 15‐year‐old spayed female mongrel presented with anorexia and an abdominal mass. The mass originated from the gall bladder and was surgically resected along with divisionectomy of the central hepatic division. Paroxysmal hypertension and tachycardia were noted during manipulation of the mass. Following resection, arterial blood pressure decreased significantly. Histopathological analysis confirmed a diagnosis of neuroendocrine neoplasm. Immunohistochemical staining for synaptophysin and chromogranin A yielded diffuse and strong positive results, while gastrin was positive in only 10% of the cells. The preoperative elevated concentrations of catecholamine in the urinalysis showed a marked decrease after surgery. Based on these findings, the tumour was diagnosed as a functional paraganglioma of the gall bladder. The patient has undergone regular thoracic radiographs and ultrasound examinations and, until 431 days after surgery, has shown no signs of metastases or recurrences. Based on our literature search, we report the first case of functional paraganglioma of the gall bladder in a dog.

show abstract

Imaging features of retroperitoneal extra‐adrenal paragangliomas in 10 dogs

Gombert

Diana

Hecht

et al. 2022

Vet Radiology Ultrasound

View full text Add to dashboard Cite

Retroperitoneal paragangliomas are rare tumors of the neuroendocrine system. Only a few canine case reports are available with rare descriptions of their imaging features.The objectives of this multi-center, retrospective case series study were to describe the diagnostic imaging features of confirmed retroperitoneal paragangliomas and specify their location. Medical records and imaging studies of 10 affected dogs with cytological or histopathologic results concordant with retroperitoneal paragangliomas were evaluated. Dogs had a median age of 9 years. Four of them had clinical signs and laboratory reports compatible with excessive production of catecholamines. Six ultrasound, four CT, four radiographic, and one MRI studies were included. The paragangliomas did not have a specific location along the aorta. They were of various sizes (median 33 mm, range: 9-85 mm of length). Masses had heterogeneous parenchyma in six of 10 dogs, regardless of the imaging modality. Strong contrast enhancement was found in all CT studies. Encircling of at least one vessel was detected in six of 10 masses, clear invasion of a vessel was identified in one of 10 masses. In five of 10 cases, the masses were initially misconstrued as lymph nodes by the on-site radiologist. Retroperitoneal paragangliomas appear along the abdominal aorta, often presenting heterogeneous parenchyma, possibly affecting the local vasculature, and displaying strong contrast enhancement on CT. Clinical signs can be secondary to mass effects or excessive catecholamine production. Underdiagnosis and misdiagnosis of this tumor are suspected as they can be silent, of small size, or confused with other structures.

show abstract

Imaging features of retroperitoneal extra‐adrenal paragangliomas in 10 dogs

Cited by 3 publications

References 44 publications

Successful treatment of acute respiratory failure following hypertensive crisis in a dog with presumed pheochromocytoma or paraganglioma

Successful treatment of acute respiratory failure following hypertensive crisis in a dog with presumed pheochromocytoma or paraganglioma

Intraoperative hypertensive crisis in a dog with functional paraganglioma of the gall bladder

Imaging features of retroperitoneal extra‐adrenal paragangliomas in 10 dogs

Contact Info

Product

Resources

About