Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide

Li, Xiaoda; Liang, Xiaolong; Yue, Xiuli; Wang, Jinrui; Li, Changhui; Deng, Zijian; Jing, Lijia; Li, Lin; Qu, Enze; Wang, Shumin; Wu, Chunlong; Wu, Huaming; Dai, Zhifei

doi:10.1039/c3tb21281e

Cited by 72 publications

(36 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a single‐modality imaging technique usually provide insufficient information for diagnosis. Considering each imaging modality possesses its own advantages and limitations, multiple‐modality imaging has drawn extensive attention in biomedical research recently because of its ability to provide more comprehensive information for accurate diagnosis . Therefore, it is undoubted that the combination of magnetic resonance (MR) and photoacoustic (PA) imaging would conduce to accurate locating of cancerous tissue for more precise guidance of PTT.…”

Section: Introductionmentioning

confidence: 99%

PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for Dual‐Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of Cancer

Liang

et al. 2015

Adv Funct Materials

223

148

View full text Add to dashboard Cite

Polypyrrole nanoparticles conjugating gadolinium chelates were successfully fabricated for dual-modal magnetic resonance imaging (MRI) and photoacoustic imaging guided photothermal therapy of cancer, from a mixture of pyrrole and pyrrole-1-propanoic acid through a facile one-step aqueous dispersion polymerization, followed by covalent attachment of gadolinium chelate, using polyethylene glycol as a linker. ). After 24 h intravenous injection of Gd-PEG-PPy NPs, the tumor sites exhibited obvious enhancement in both T 1 -weighted MRI intensity and photoacoustic signal compared with that before injection, indicating the effi cient accumulation of Gd-PEG-PPy NPs due to the introduction of the PEG layer onto the particle surface. In addition, tumor growth could be effectively inhibited after treatment with Gd-PEG-PPy NPs in combination with near-infrared laser irradiation. The passive targeting and high MRI/photoacoustic contrast capability of Gd-PEG-PPy NPs are quite favorable for precise cancer diagnosing and locating the tumor site to guide the external laser irradiation for photothermal ablation of tumors without damaging the surrounding healthy tissues. Therefore, Gd-PEG-PPy NPs may assist in better monitoring the therapeutic process, and contribute to developing more effective "personalized medicine," showing great potential for cancer diagnosis and therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for Dual‐Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of Cancer

Liang

et al. 2015

Adv Funct Materials

223

148

View full text Add to dashboard Cite

show abstract

“…Expedition of novel reliable energy replacements to gasoline has been a leading challenge throughout the current century to meet the imminent energy wants [7][8][9]. Anaerobic digestion (AD) [10][11][12] presents an outstanding opening for energy conversion and pollution minimization mutually [13].…”

Section: Introductionmentioning

confidence: 99%

Influence of flow rate variation on bio-energy generation during anaerobic co-digestion

Siddique

Sakinah

Zularisam

2015

Journal of Industrial and Engineering Chemistry

View full text Add to dashboard Cite

“…Other important in vitro therapeutic applications of graphane nanomaterials are phototherapies, such as PTT and photodynamic therapy (PDT), which are used to control disease by specific light irradiation [109][110][111][112][113][114][115][116]. The advantage of phototherapy is that graphene nano-agents can specifically target and kill cancer cells which are exposed to the light, without significantly damaging the normal organs in dark, thus exhibiting remarkable advantages in terms of enhancing the cancer killing specificity and reducing the side effects [31].…”

Section: Graphene and Its Derivatives As Bio-delivery Carriersmentioning

confidence: 99%

Graphene and its derivatives as biomedical materials: future prospects and challenges

2018

View full text Add to dashboard Cite

Graphene and its derivatives possess some intriguing properties, which generates tremendous interests in various fields, including biomedicine. The biomedical applications of graphene-based nanomaterials have attracted great interests over the last decade, and several groups have started working on this field around the globe. Because of the excellent biocompatibility, solubility and selectivity, graphene and its derivatives have shown great potential as biosensing and bio-imaging materials. Also, due to some unique physico-chemical properties of graphene and its derivatives, such as large surface area, high purity, good bio-functionalizability, easy solubility, high drug loading capacity, capability of easy cell membrane penetration, etc., graphene-based nanomaterials become promising candidates for bio-delivery carriers. Besides, graphene and its derivatives have also shown interesting applications in the fields of cell-culture, cell-growth and tissue engineering. In this article, a comprehensive review on the applications of graphene and its derivatives as biomedical materials has been presented. The unique properties of graphene and its derivatives (such as graphene oxide, reduced graphene oxide, graphane, graphone, graphyne, graphdiyne, fluorographene and their doped versions) have been discussed, followed by discussions on the recent efforts on the applications of graphene and its derivatives in biosensing, bio-imaging, drug delivery and therapy, cell culture, tissue engineering and cell growth. Also, the challenges involved in the use of graphene and its derivatives as biomedical materials are discussed briefly, followed by the future perspectives of the use of graphene-based nanomaterials in bio-applications. The review will provide an outlook to the applications of graphene and its derivatives, and may open up new horizons to inspire broader interests across various disciplines.

show abstract

Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide

Cited by 72 publications

References 38 publications

PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for Dual‐Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of Cancer

PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for Dual‐Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of Cancer

Influence of flow rate variation on bio-energy generation during anaerobic co-digestion

Graphene and its derivatives as biomedical materials: future prospects and challenges

Contact Info

Product

Resources

About