Imaging inflammation with 99Tcm HMPAO labelled leucocytes

Reynolds, Justin; Graham, D.; Smith, Francis W.

doi:10.1016/s0009-9260(05)81933-6

Cited by 26 publications

(4 citation statements)

References 4 publications

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“…and specificity for infection (Datz and Thorne 1986a;Reynolds et al 1990;Charron et al 1994). These characteristics are reflected in its frequent clinical application in the human field as a diagnostic aid for a variety of conditions including abdominal abscessation, osteomyelitis, inflammatory bowel disease and neoplasia (Roddie et al 1988).…”

Section: Discussionmentioning

confidence: 99%

“…111 Indium-oxine ( 111 In-oxine) and 99m Tc-hexamethylpropyleneamine oxime ( 99m Tc-HMPAO) are the two most commonly used radiopharmaceuticals. 99m Tc-HMPAO appears to have some advantages over 111 In-oxine with regard to overall image characteristics, half-life and expense (Reynolds et al 1990;Daniel et al 1992;East et al 2000) and is the most frequently used radiopharmaceutical for the labelling of equine leucocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Doubts have been expressed about whether low-grade abdominal inflammation may be masked in the horse by physiological bowel activity resulting from biliary excretion of radioisotope (Long et al 2000). This certainly presents a problem in human medicine in spite of the superior image characteristics; clinicians have advocated early acquisitions in order to avoid interpretative difficulties where bowel activity, due to hepatobiliary excretion of free 99m Tc-complexes, is present (Roddie et al 1988;Mountford et al 1990;Reynolds et al 1990;Lantto et al 1991). For this reason, it has been suggested that 111 In-oxine may be preferred for abdominal imaging in the horse (Daniel et al 1992), and irregular bowel activity found during delayed acquisitions should be regarded with caution (Hoskinson and Tucker 1996).…”

Section: Fig 4: Focus Of Increased Activity (Arrow) On the Right Midvmentioning

confidence: 99%

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Use of ^99mtechnetium hexamethylpropyleneamine oxime labelled leucocyte scintigraphy in equine medical investigations: 8 cases

Ramzan

Malton

McGLADDERY

2004

Equine Veterinary Education

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Fig 4: Focus Of Increased Activity (Arrow) On the Right Midvmentioning

confidence: 99%

See 1 more Smart Citation

Use of ^99mtechnetium hexamethylpropyleneamine oxime labelled leucocyte scintigraphy in equine medical investigations: 8 cases

Ramzan

Malton

McGLADDERY

2004

Equine Veterinary Education

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“…Technetium-99m hexamethylpropylemeamine oxime (HMPAO) has recently been shown to radiolabel leukocytes in vitro, and good results in the identification of inflammatory lesions in adults have been published (1). The 99m Tc-HMPAO label has many theoretical advantages over 111 Indium oxime-labeled white blood cell (WBC) (2), including better image quality, shorter acquisition time, lower radiation dose, and lower cost.…”

mentioning

confidence: 99%

Assessment of terminal ileal and colonic inflammation in Crohn's disease with 99mTc-WBC

Charron¹,

Rosario²,

Kocoshis³

1999

SPAE

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We evaluated the sensitivity and specificity of Technetium-99m (99mTc)-white blood cell (WBC) for identifying terminal ileum inflammation in children with Crohn's disease (CD). In 40 children, total colonoscopy was done within a few days of a 99mTc-WBC scan carried out to evaluate the inflammation in children with CD. In 38 patients the intensity and the location of inflammation shown on the 99mTc-WBC scan of the colon were similar to the biopsy result of the colonoscopy. The sensitivity of the 99mTc-WBC scan was 97% in assessing colonic inflammation compared with colonoscopy. The 99mTc-WBC scan allowed evaluation of inflammation in the terminal ileum in 21 patients in whom the endoscopist did not cannulate the terminal ileum. Of the 19 patients in whom the terminal ileum was visualized endoscopically (14) or surgically (5), the 99mTc-WBC scan findings showed a similar degree of inflammation in 17. The 99mTc-WBC scan was abnormal in 10 of these 21 children in whom the gastroenterologist did not reach the terminal ileum. In these children with no ileoscopy the results of the 99mTc-WBC scan were consistent with the laboratory values, the gastroenterologist's clinical assessment and with long-term clinical follow-up. Finally, the 99mTc-WBC scan of 83 controls did not reveal any false-positive findings in the terminal ileum (colonoscopy result available in 30 controls). When total colonoscopy or ileoscopy is not performed or when contrast radiography is negative or unable to differentiate CD from lymphoid nodular hyperplasia, scintigraphy can demonstrate the presence of ileitis and/or colitis.

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Distribution of acute bowel inflammation determined by technetium-labeled white blood cells in children with inflammatory bowel disease

1998

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Knowledge of the distribution of disease in patients with inflammatory bowel disease is important because it has diagnostic, prognostic, and therapeutic implications. We studied 215 patients with 99mTc-HMPAO-white blood cell scans, of whom 80 had Crohn's disease (CD), 34 had active ulcerative colitis (UC), and 31 were controls. In our 77 cases of active CD, uptake was seen exclusively in the small bowel in 18% of patients, only the large bowel in 44%, and both the large and small bowel in 38% of patients. Discontinuous colitis was seen in 63 of these patients. In the 29 cases of active UC, the uptake involved the entire colon in 50% of patients, extended farther than the sigmoid in 27% of patients, and was limited to the rectosigmoid in 23%. In the 29 cases of active UC, four of the scans incorrectly revealed discontinuous accumulation of 99mTc-HMPAO-WBC. In 31 controls, no significant colonic uptake was seen. Isolated small bowel involvement with CD is observed less frequently in children undergoing 99mTc-HMPAO-WBC scanning than in adults. In children, the segmental distribution of inflammation as depicted with 99mTc-HMPAO-WBC is similar to the radiologic distribution.

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Imaging inflammation with 99Tcm HMPAO labelled leucocytes

Cited by 26 publications

References 4 publications

Use of ^99mtechnetium hexamethylpropyleneamine oxime labelled leucocyte scintigraphy in equine medical investigations: 8 cases

Use of ^99mtechnetium hexamethylpropyleneamine oxime labelled leucocyte scintigraphy in equine medical investigations: 8 cases

Assessment of terminal ileal and colonic inflammation in Crohn's disease with 99mTc-WBC

Distribution of acute bowel inflammation determined by technetium-labeled white blood cells in children with inflammatory bowel disease

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Imaging inflammation with 99Tcm HMPAO labelled leucocytes

Cited by 26 publications

References 4 publications

Use of 99mtechnetium hexamethylpropyleneamine oxime labelled leucocyte scintigraphy in equine medical investigations: 8 cases

Use of 99mtechnetium hexamethylpropyleneamine oxime labelled leucocyte scintigraphy in equine medical investigations: 8 cases

Assessment of terminal ileal and colonic inflammation in Crohn's disease with 99mTc-WBC

Distribution of acute bowel inflammation determined by technetium-labeled white blood cells in children with inflammatory bowel disease

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Use of ^99mtechnetium hexamethylpropyleneamine oxime labelled leucocyte scintigraphy in equine medical investigations: 8 cases

Use of ^99mtechnetium hexamethylpropyleneamine oxime labelled leucocyte scintigraphy in equine medical investigations: 8 cases