Imaging Lymphatic System in Breast Cancer Patients with Magnetic Resonance Lymphangiography

Lü, Qing; Kassir, Mohammad M.; DelProposto, Zachary; Dai, Yongming; Sun, Jing; Haacke, Mark; Hu, Jiani

doi:10.1371/journal.pone.0069701

Cited by 20 publications

(16 citation statements)

References 35 publications

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“…Here, we demonstrated that breast tumors lacking VEGF-D expression do not exhibit a defect in primary tumor or lymph nodes lymphangiogenesis, but have a reduced amount of dilated lymphatic vessels associated with an inhibition of metastasis. Our findings suggested that this process is restricted to breast cancer, in agreement with previous studies showing a correlation between metastases and dilated lymphatic vessels in breast cancer patients (40).…”

Section: Discussionsupporting

confidence: 93%

Nucleolin Promotes Heat Shock–Associated Translation of VEGF-D to Promote Tumor Lymphangiogenesis

et al. 2016

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The vascular endothelial growth factor VEGF-D promotes metastasis by inducing lymphangiogenesis and dilatation of the lymphatic vasculature, facilitating tumor cell extravasion. Here we report a novel level of control for VEGF-D expression at the level of protein translation. In human tumor cells, VEGF-D colocalized with eIF4GI and 4E-BP1, which can program increased initiation at IRES motifs on mRNA by the translational initiation complex. In murine tumors, the steady-state level of VEGF-D protein was increased despite the overexpression and dephosphorylation of 4E-BP1, which downregulates protein synthesis, suggesting the presence of an internal ribosome entry site (IRES) in the 5 0 UTR of VEGF-D mRNA. We found that nucleolin, a nucleolar protein involved in ribosomal maturation, bound directly to the 5 0 UTR of VEGF-D mRNA, thereby improving its translation following heat shock stress via IRES activation. Nucleolin blockade by RNAi-mediated silencing or pharmacologic inhibition reduced VEGF-D translation along with a subsequent constriction of lymphatic vessels in tumors. Our results identify nucleolin as a key regulator of VEGF-D expression, deepening understanding of lymphangiogenesis control during tumor formation.

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Section: Discussionsupporting

confidence: 93%

Nucleolin Promotes Heat Shock–Associated Translation of VEGF-D to Promote Tumor Lymphangiogenesis

et al. 2016

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“…Meme kanseri hastalarında ALN tutulumu hastalığın prognozunu olumsuz yönde etkilediği gibi klinik ve cerrahi yaklaşımı belirleyen önemli bir faktördür. Malign meme tümörünün aksiller lenf nodlarına yayılımı, 10 yıllık rekürrens oranını %20-30'dan %70'lere çıkarmaktadır [2]. Bu nedenle, yeni tanı almış tüm meme kanseri hastalarında ALN tutulumunun değerlendirilmesi çok önemli bir zorunluluktur.…”

Section: Derlemeunclassified

“…Level-2 veya orta aksiller lenf nodları pektoralis minör kasının arkasında yer alır ve patolojik boyut ya da ekojenitede olmadığı takdirde kolayca saptanamayabilir. Level 3, yani apikal aksiller lenf nodları pektoralis minör kasının medialinde infraklaviküler bölgede yer alır [2,5]. Rotter (interpektoral) nodları, level-2 orta aksiller lenf nodlarının pektoralis majör ve minör kasları arasında yer alan bir bölümüdür [5].…”

Section: Meme Lenfatik Sistem Anatomisi Ve Lenf Nodu Histolojisiunclassified

Radiology of axillary region in breast cancer staging: Mammography, ultrasonography, magnetic resonance imaging and lymphography techniques

Aydın¹

2018

Türk Radyoloji Derg

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Breast cancer is the most common cause of cancer-related death in women. Axillary lymph node metastasis is one of the most important prognostic factor that affect the recurrence of disease, survival and clinical or surgical approach. Therefore, evaluation of axillary lymph node involvement is an important necessity in all newly diagnosed breast cancer patients. Although, axillary lymph node dissection and pathology can established the final diagnosis, less invasive methods are needed because of serious regional morbidity of the method. Nowadays, sentinel lymph node biopsy has become standard practice for the evaluation of nodal disease in clinically axillary negative breast cancer patients. However, sentinel lymph node biopsy can have some complications and undesirable effects such as prolonged operative time, a second surgical scar, painful injections before surgery and seroma. Radiological techniques which decrease the necessity of sentinel lymph node biopsy are needed.

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“…The technique is relatively non-invasive and can be used to identify anatomic and physiological abnormalities associated with lymphatic dysfunction in order to determine further treatment strategies (Lohrmann et al, 2009). MRL has shown promise in imaging the lymphatic system in multiple pathologies including breast cancer (Lu et al, 2013), lymphedema (Lohrmann et al, 2007; Rane et al, 2013) and diffuse lymphangiomatosis (Lohrmann et al, 2011). Imaging agents with better sensitivity and specificity are under development (McDermott et al, 2013) and will improve the ability of MRL to identify pathologies in the lymphatic system.…”

Section: Imaging the Lymphatic System In The Clinic For Assessment Ofmentioning

confidence: 99%

Imaging the lymphatic system

Munn

Padera

2014

Microvascular Research

110

101

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Visualization of the lymphatic system is clinically necessary during diagnosis or treatment of many conditions and diseases; it is used for identifying and monitoring lymphedema, for detecting metastatic lesions during cancer staging and for locating lymphatic structures so they can be spared during surgical procedures. Imaging lymphatic anatomy and function also plays an important role in experimental studies of lymphatic development and function, where spatial resolution and accessibility are better. Here, we review technologies for visualizing and imaging the lymphatic system for clinical applications. We then describe the use of lymphatic imaging in experimental systems as well as some of the emerging technologies for improving these methodologies.

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Imaging Lymphatic System in Breast Cancer Patients with Magnetic Resonance Lymphangiography

Cited by 20 publications

References 35 publications

Nucleolin Promotes Heat Shock–Associated Translation of VEGF-D to Promote Tumor Lymphangiogenesis

Nucleolin Promotes Heat Shock–Associated Translation of VEGF-D to Promote Tumor Lymphangiogenesis

Radiology of axillary region in breast cancer staging: Mammography, ultrasonography, magnetic resonance imaging and lymphography techniques

Imaging the lymphatic system

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