Imaging mass spectrometry differentiates the effects of doxorubicin formulations on non-targeted tissues

Abstract

Imaging mass spectrometry indicated a wide range of chemical disturbances in a model of non-targeted organs of rats treated with different formulations of doxorubicin and enabled the differentiation of drug formulation-specific effects.

Novel PLGA-based nanoformulation decreases doxorubicin-induced cardiotoxicity

“…In our previous study conducted on the kidneys of DOX-treated rats, we have shown that the use of MSI analysis can provide a wide variety of information for the safety profiling of drug formulations. 38 Here, we decided to focus on the metabolic and lipidomic markers involved in DOX-induced cytotoxicity and cellular response, namely spermine, Car, Cer, and LysoPC. An overview of their biological effects related to DOX toxic effects and their tentative annotations are given in Table 1.…”

“…Characterization of lipoDOX and PLGADOX formulations was done as described previously by means of their shape, size, and size distribution, as well as surface charge after dilution with saline solution (see ESI †). 38…”