Imaging specific cell-surface sialylation using DNA dendrimer-assisted FRET

Tang, Jinlu; Li, Bo; Qi, Cuihua; Wang, Zhaoting; Yin, Ke; Guo, Linyan; Zhang, Weihang; Yuan, Baoyin

doi:10.1016/j.talanta.2022.123399

Cited by 5 publications

(2 citation statements)

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“…Particularly during the onset and progression of cancer, the alteration of the sialylation state on the surface of specific cells represents a wealth of cancer-related data. Among the numerous imaging tools, the FRET technique is an ingenious approach upon which researchers have devised a series of strategies for imaging sialylation acidification on specific cell surfaces [ 81 , 82 ].…”

Section: Application Of Cell Membrane Imagingmentioning

confidence: 99%

DNA-Based Fluorescent Nanoprobe for Cancer Cell Membrane Imaging

Wu,

Shuai,

Nie

et al. 2024

Molecules

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As an important barrier between the cytoplasm and the microenvironment of the cell, the cell membrane is essential for the maintenance of normal cellular physiological activities. An abnormal cell membrane is a crucial symbol of body dysfunction and the occurrence of variant diseases; therefore, the visualization and monitoring of biomolecules associated with cell membranes and disease markers are of utmost importance in revealing the biological functions of cell membranes. Due to their biocompatibility, programmability, and modifiability, DNA nanomaterials have become increasingly popular in cell fluorescence imaging in recent years. In addition, DNA nanomaterials can be combined with the cell membrane in a specific manner to enable the real-time imaging of signal molecules on the cell membrane, allowing for the real-time monitoring of disease occurrence and progression. This article examines the recent application of DNA nanomaterials for fluorescence imaging on cell membranes. First, we present the conditions for imaging DNA nanomaterials in the cell membrane microenvironment, such as the ATP, pH, etc. Second, we summarize the imaging applications of cell membrane receptors and other molecules. Finally, some difficulties and challenges associated with DNA nanomaterials in the imaging of cell membranes are presented.

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Section: Application Of Cell Membrane Imagingmentioning

confidence: 99%

DNA-Based Fluorescent Nanoprobe for Cancer Cell Membrane Imaging

Wu,

Shuai,

Nie

et al. 2024

Molecules

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“…7B ). 110 Multiple FRET donors were labeled on target molecules by metabolic oligoengineering (MOE), and DNA dendrimers labeled the acceptors. Targeted recognition by aptamers significantly improved the FRET results.…”

Section: Design Strategies For Aptamer-based Molecular Imagingmentioning

confidence: 99%