Imaging techniques in nanomedical research

Calderan, Laura; Malatesta, Manuela

doi:10.4081/ejh.2020.3151

Cited by 11 publications

(4 citation statements)

References 91 publications

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“…In terms of pharmaceutical aspects, preliminary screening of new formulations can focus on size, PDI, zeta potential, drug loading efficiency, drug release data, stability, and nanoimaging approaches. [307][308][309][310][311][312] DDSs that are less susceptible to phagocytosis or non-specific interactions can be designed based on optimized zeta potential values. The literature suggests that zeta potentials between −10 and +10 mV can be preferable for drug delivery purposes.…”

Section: Which Checkpoints Need To Be Passed For New Formulations To ...mentioning

confidence: 99%

Future Nanotechnology‐Based Strategies for Improved Management of Helicobacter pylori Infection

Kamankesh,

Yadegar,

Llopis‐Lorente

et al. 2023

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Helicobacter pylori (H. pylori) is a recalcitrant pathogen, which can cause gastric disorders. During the past decades, polypharmacy‐based regimens, such as triple and quadruple therapies have been widely used against H. pylori. However, polyantibiotic therapies can disturb the host gastric/gut microbiota and lead to antibiotic resistance. Thus, simpler but more effective approaches should be developed. Here, some recent advances in nanostructured drug delivery systems to treat H. pylori infection are summarized. Also, for the first time, a drug release paradigm is proposed to prevent H. pylori antibiotic resistance along with an IVIVC model in order to connect the drug release profile with a reduction in bacterial colony counts. Then, local delivery systems including mucoadhesive, mucopenetrating, and cytoadhesive nanobiomaterials are discussed in the battle against H. pylori infection. Afterward, engineered delivery platforms including polymer‐coated nanoemulsions and polymer‐coated nanoliposomes are poposed. These bioinspired platforms can contain an antimicrobial agent enclosed within smart multifunctional nanoformulations. These bioplatforms can prevent the development of antibiotic resistance, as well as specifically killing H. pylori with no or only slight negative effects on the host gastrointestinal microbiota. Finally, the essential checkpoints that should be passed to confirm the potential effectiveness of anti‐H. pylori nanosystems are discussed.

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Section: Which Checkpoints Need To Be Passed For New Formulations To ...mentioning

confidence: 99%

Future Nanotechnology‐Based Strategies for Improved Management of Helicobacter pylori Infection

Kamankesh,

Yadegar,

Llopis‐Lorente

et al. 2023

Small

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“…However, due to high cost, excessive time consumption, and using plenty of animals, the previously mentioned in vitro experiments are currently being utilized [ 272 ]. Imaging techniques like optical imaging, microscopy MRI [ 276 ], CT [ 277 ], and PET scanning, are also the suitable options for real-time monitoring of NPs fate and toxicity in vitro as well as in vivo [ 278 , 279 ].…”

Section: Loopholes In Designed Nano-ddsmentioning

confidence: 99%

Nanotechnology based solutions for anti-leishmanial impediments: a detailed insight

2021

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As a neglected tropical disease, Leishmaniasis is significantly instigating morbidity and mortality across the globe. Its clinical spectrum varies from ulcerative cutaneous lesions to systemic immersion causing hyperthermic hepato-splenomegaly. Curbing leishmanial parasite is toughly attributable to the myriad obstacles in existing chemotherapy and immunization. Since the 1990s, extensive research has been conducted for ameliorating disease prognosis, by resolving certain obstacles of conventional therapeutics viz. poor efficacy, systemic toxicity, inadequate drug accumulation inside the macrophage, scarce antigenic presentation to body’s immune cells, protracted length and cost of the treatment. Mentioned hurdles can be restricted by designing nano-drug delivery system (nano-DDS) of extant anti-leishmanials, phyto-nano-DDS, surface modified—mannosylated and thiolated nano-DDS. Likewise, antigen delivery with co-transportation of suitable adjuvants would be achievable through nano-vaccines. In the past decade, researchers have engineered nano-DDS to improve the safety profile of existing drugs by restricting their release parameters. Polymerically-derived nano-DDS were found as a suitable option for oral delivery as well as SLNs due to pharmacokinetic re-modeling of drugs. Mannosylated nano-DDS have upgraded macrophage internalizing of nanosystem and the entrapped drug, provided with minimal toxicity. Cutaneous Leishmaniasis (CL) was tackling by the utilization of nano-DDS designed for topical delivery including niosomes, liposomes, and transfersomes. Transfersomes, however, appears to be superior for this purpose. The nanotechnology-based solution to prevent parasitic resistance is the use of Thiolated drug-loaded and multiple drugs loaded nano-DDS. These surfaces amended nano-DDS possess augmented IC50 values in comparison to conventional drugs and un-modified nano-DDS. Phyto-nano-DDS, another obscure horizon, have also been evaluated for their anti-leishmanial response, however, more intense assessment is a prerequisite. Impoverished Cytotoxic T-cells response followed by Leishmanial antigen proteins delivery have also been vanquished using nano-adjuvants. The eminence of nano-DDS for curtailment of anti-leishmanial chemotherapy and immunization associated challenges are extensively summed up in this review. This expedited approach is ameliorating the Leishmaniasis management successfully. Alongside, total to partial eradication of this disease can be sought along with associated co-morbidities.

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“…They are particularly suitable for the dynamic tri-dimensional tracking of nanoparticulates and for longitudinal studies but they are characterized by a low resolution (in the order of hundreds of micrometers), which prevents the study of the spatial and functional relationships at a histological and cytological level. Light and electron microscopy have mostly been used to monitor the uptake and relocation of nanoparticles inside tissues and cells [ 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Transmission Electron Microscopy as a Powerful Tool to Investigate the Interaction of Nanoparticles with Subcellular Structures

Malatesta

2021

IJMS

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Nanomedical research necessarily involves the study of the interactions between nanoparticulates and the biological environment. Transmission electron microscopy has proven to be a powerful tool in providing information about nanoparticle uptake, biodistribution and relationships with cell and tissue components, thanks to its high resolution. This article aims to overview the transmission electron microscopy techniques used to explore the impact of nanoconstructs on biological systems, highlighting the functional value of ultrastructural morphology, histochemistry and microanalysis as well as their fundamental contribution to the advancement of nanomedicine.

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Imaging techniques in nanomedical research

Cited by 11 publications

References 91 publications

Future Nanotechnology‐Based Strategies for Improved Management of Helicobacter pylori Infection

Future Nanotechnology‐Based Strategies for Improved Management of Helicobacter pylori Infection

Nanotechnology based solutions for anti-leishmanial impediments: a detailed insight

Transmission Electron Microscopy as a Powerful Tool to Investigate the Interaction of Nanoparticles with Subcellular Structures

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