Imaging the D3 dopamine receptor across behavioral and drug addictions: Positron emission tomography studies with [11C]-(+)-PHNO

Elucidating the role of D4 receptors in mediating attributions of salience to incentive stimuli on Pavlovian conditioned approach and conditioned reinforcement paradigms

“…In this regard D 3 receptors appear ideally placed, given that these receptors are densely localized both pre and postsynaptically within the NAc [15]. D 3 receptors have been suggested to play a key role in the manifestation of human gambling (see [14] for review) and have been repeatedly implicated in cue-driven reinstatement of drug seeking in animal models [7,55]. However, with regards to autoshaping, mixed results have been observed with the partially selective D 3 agonist SB-277011A and the more selective antagonist 7-OH-DPAT did not alter performance [44,76], intimating that D 3 receptors cannot exclusively account for responsivity to CS+ on these simple behavioural tasks.…”

Exploring the relationship between social attachment and dopamine D2/3 receptor availability in the brains of healthy humans using [11C]-(+)-PHNO

“…Statistical analyses were conducted using SPSS (v.12.0; SPSS, Chicago, IL, USA) and GraphPad (v.5.0; GraphPad Software, La Jolla, CA, USA). To our knowledge, this is to date the largest sample ( n = 32) to examine how [ 11 C]-(+)-PHNO BP ND is related to any self-report measure, not just personality (Boileau et al, 2015; Caravaggio et al, 2014; Di Ciano et al, 2015; Matuskey et al, 2015; Payer et al, 2015; Suridjan et al, 2012). Moreover, this sample is larger than those studies examining the relationship between baseline [ 11 C]-raclopride BP ND and attachment/detachment.…”

“…In both healthy persons and cocaine dependent subjects, less D 3 R availability in the midbrain has been correlated with greater self-reported social status (Matuskey et al, 2015). Thus, exploring the relationship between attachment and in vivo D 3 R availability in humans is novel, and may offer new insights as several investigations have noted potential differences in D 2 R versus D 3 R regulation in several conditions (Boileau, Nakajima, & Payer, 2015; Le Foll, Wilson, Graff, Boileau, & Di Ciano, 2014; Nakajima et al, 2013). …”

Heightened Dopaminergic Response to Amphetamine at the D3 Dopamine Receptor in Methamphetamine Users

“…In contrast, a recent body of work suggests that, unlike other measured dopaminergic markers, the D 3 receptor might be upregulated in animal models (Le Foll et al, 2005;Neisewander et al, 2004) and in postmortem (Mash, 1997;Staley and Mash, 1996) and living brain of humans with stimulant (Boileau et al, 2012;Matuskey et al, 2014;Payer et al, 2014) and perhaps alcohol (Erritzoe et al, 2014) addiction (see (Boileau et al, 2015b) for a review). General interest in D 3 receptor has developed in large part because of preferential expression of D 3 in limbic brain areas associated with reward/motivation (eg, ventral striatum) and because animal models suggested that D 3 -selective antagonists decrease drug-seeking behavior.…”