Imaging the heart’s brain: Simultaneous innervation/perfusion analysis in the era of new CZT cameras

Liga, Riccardo; Gimelli, Alessia

doi:10.1007/s12350-016-0541-0

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…The innervation/perfusion mismatch on the SPECT myocardial images could be very useful in identifying the trigger zone, which is the viable but sympathetically denervated myocardial area. Such mismatch strongly predicts adverse prognosis of the patients, particularly with respect to malignant arrhythmic events (Assante andAcampa 2017, Liga andGimelli 2017). The high sensitivity and superior energy resolution of current CZT cameras provide the opportunity of dual-radionuclide innervation/perfusion imaging with reduced injection dose and improved image quality as compared with the conventional cameras.…”

Section: Czt Crosstalk Correction For Multiple Radionuclide Studiesmentioning

confidence: 99%

Recent advances in cardiac SPECT instrumentation and imaging methods

Liu

2019

Phys. Med. Biol.

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Cardiac SPECT continues to play a critical role in detecting and managing cardiovascular disease, in particularly coronary artery disease (CAD) (Jaarsma et al 2012 J. Am. Coll. Cardiol. 59 1719–28), (Agostini et al 2016 Eur. J. Nucl. Med. Mol. Imaging 43 2423–32). While conventional dual-head SPECT scanners using parallel-hole collimators and scintillation crystals with photomultiplier tubes are still the workhorse of cardiac SPECT, they have the limitations of low photon sensitivity (~130 count s−1 MBq−1), poor image resolution (~15 mm) (Imbert et al 2012 J. Nucl. Med. 53 1897–903), relatively long acquisition time, inefficient use of the detector, high radiation dose, etc. Recently our field observed an exciting growth of new developments of dedicated cardiac scanners and collimators, as well as novel imaging algorithms for quantitative cardiac SPECT. These developments have opened doors to new applications with potential clinical impact, including ultra-low-dose imaging, absolute quantification of myocardial blood flow (MBF) and coronary flow reserve (CFR), multi-radionuclide imaging, and improved image quality as a result of attenuation, scatter, motion, and partial volume corrections (PVCs). In this article, we review the recent advances in cardiac SPECT instrumentation and imaging methods. This review mainly focuses on the most recent developments published since 2012 and points to the future of cardiac SPECT from an imaging physics perspective.

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Section: Czt Crosstalk Correction For Multiple Radionuclide Studiesmentioning

confidence: 99%

Recent advances in cardiac SPECT instrumentation and imaging methods

Liu

2019

Phys. Med. Biol.

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“…When compared to SPECT equipped with a traditional sodium iodide detector (NaI SPECT), SPECT equipped with a CZT semiconductor detector (CZT SPECT) provides better image quality, and the spatial resolution, energy resolution, and contrast of CZT SPECT images have signi cantly improved [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, the development of digital universal cadmium zinc telluride (CZT) cameras has promoted new advances in SPECT imaging technology. When compared to SPECT equipped with a traditional sodium iodide detector (NaI SPECT), cadmium zinc telluride single photon emission computed tomography (CZT SPECT) provides better image quality, and the spatial resolution, energy resolution and contrast of CZT SPECT images have significantly improved [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Optimization of image reconstruction method of cerebral blood flow perfusion imaging with digital CZT SPECT

Zhou

Wang

et al. 2022

Nuclear Medicine Communications

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Purpose: To evaluate the effects of ltered back projection (FBP), ordered subset expectation maximisation (OSEM), and different lters on cadmium zinc telluride single photon emission computed tomography (CZT SPECT) cerebral blood perfusion image quality to optimise the image reconstruction method.Methods: Jaszczak phantom and patients with clinical cerebral ischemia were selected as study subjects. Under routine clinical conditions, tomographic imaging was performed on the phantom and patients with clinical cerebral ischemia. Image processing included image reconstruction using ltered back projection with Chang's attenuation correction (FBP ChangAC ) and OSEM algorithm with CT-based attenuation correction (CTAC), scatter correction (SC), resolution recovery (RR) (OSEM CTAC-SC-RR ), and the ltering method used Butterworth (Bw) and Gauss (Gs) lters. Visual and semi-quantitative parameters (integral uniformity, root mean square noise (RMS noise), and contrast and contrast-to-noise ratio (CNR)) were used to evaluate image quality to optimise image reconstruction parameters. One-way and two-way ANOVA were used to process phantom and clinical data.Results: In the tomographic images of phantom and brain imaging of patients, FBP+Bw had the best uniformity and the lowest noise level, while OSEM+Bw had the best contrast. Semi-quantitative analysis showed that the integral uniformity of FBP+Bw was signi cantly higher than that of OSEM+Bw and OSEM+Gs (p <0.05), and that the RMS noise of FBP+Bw was signi cantly lower than that of OSEM+Bw and OSEM+Gs (p <0.001). The contrast of FBP+Bw and OSEM+Bw in the cold sphere diameter ≥ 2 cm group was signi cantly higher than that of OSEM+Gs (p <0.001), while the CNR of FBP+Bw was signi cantly higher than that of OSEM+Bw and OSEM+Gs (p <0.001) ; the contrast of OSEM+Bw cold sphere diameter < 2 cm was signi cantly higher than that of FBP+Bw (p <0.01). The semi-quantitative analysis results of the patient's cerebral perfusion tomography were consistent with the model. Conclusion:In CZT SPECT cerebral blood ow perfusion imaging, images with lesion sizes greater than 2 cm were suitable for FBP+Bw (fc=0.40, n=10), and the image with lesion size less than 2 cm was suitable for OSEM+Bw (EM=60, fc=0.45, n=10). The reconstruction method of OSEM+Gs (EM=80, full width at half maximum [FWHM]=3.25) was not suitable for cerebral blood perfusion imaging.

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Section: Introductionmentioning

confidence: 99%

Optimization of Image Reconstruction Method of Cerebral Blood Flow Perfusion Imaging with Digital CZT SPECT

Zhou

Wang

et al. 2021

Preprint

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Purpose: To evaluate the effects of filtered back projection (FBP), ordered subset expectation maximisation (OSEM), and different filters on cadmium zinc telluride single photon emission computed tomography (CZT SPECT) cerebral blood perfusion image quality to optimise the image reconstruction method.Methods: Jaszczak phantom and patients with clinical cerebral ischemia were selected as study subjects. Under routine clinical conditions, tomographic imaging was performed on the phantom and patients with clinical cerebral ischemia. Image processing included image reconstruction using filtered back projection with Chang’s attenuation correction (FBPChangAC) and OSEM algorithm with CT-based attenuation correction (CTAC), scatter correction (SC), resolution recovery (RR) (OSEMCTAC-SC-RR), and the filtering method used Butterworth (Bw) and Gauss (Gs) filters. Visual and semi-quantitative parameters (integral uniformity, root mean square noise (RMS noise), and contrast and contrast-to-noise ratio (CNR)) were used to evaluate image quality to optimise image reconstruction parameters. One-way and two-way ANOVA were used to process phantom and clinical data.Results: In the tomographic images of phantom and brain imaging of patients, FBP+Bw had the best uniformity and the lowest noise level, while OSEM+Bw had the best contrast. Semi-quantitative analysis showed that the integral uniformity of FBP+Bw was significantly higher than that of OSEM+Bw and OSEM+Gs (p <0.05), and that the RMS noise of FBP+Bw was significantly lower than that of OSEM+Bw and OSEM+Gs (p <0.001). The contrast of FBP+Bw and OSEM+Bw in the cold sphere diameter ≥ 2 cm group was significantly higher than that of OSEM+Gs (p <0.001), while the CNR of FBP+Bw was significantly higher than that of OSEM+Bw and OSEM+Gs (p <0.001) ; the contrast of OSEM+Bw cold sphere diameter < 2 cm was significantly higher than that of FBP+Bw (p <0.01). The semi-quantitative analysis results of the patient's cerebral perfusion tomography were consistent with the model.Conclusion: In CZT SPECT cerebral blood flow perfusion imaging, images with lesion sizes greater than 2 cm were suitable for FBP+Bw (fc=0.40, n=10), and the image with lesion size less than 2 cm was suitable for OSEM+Bw (EM=60, fc=0.45, n=10). The reconstruction method of OSEM+Gs (EM=80, full width at half maximum [FWHM]=3.25) was not suitable for cerebral blood perfusion imaging.

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Imaging the heart’s brain: Simultaneous innervation/perfusion analysis in the era of new CZT cameras

Cited by 5 publications

References 21 publications

Recent advances in cardiac SPECT instrumentation and imaging methods

Recent advances in cardiac SPECT instrumentation and imaging methods

Optimization of image reconstruction method of cerebral blood flow perfusion imaging with digital CZT SPECT

Optimization of Image Reconstruction Method of Cerebral Blood Flow Perfusion Imaging with Digital CZT SPECT

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