Imaging the pulmonary extracellular matrix

Wijsman, Pieta; Smoorenburg, Lisa H. van; Bruin, Daniël M. de; Annema, Jouke T.; Kerstjens, Huib A. M.; Mets, Onno M.; Berge, Maarten van den; Bonta, Peter I.; Burgess, Janette K.

doi:10.1016/j.cophys.2021.05.007

Cited by 2 publications

(3 citation statements)

References 61 publications

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“…The development of advanced imaging techniques and diagnostic tools is poised to revolutionize the real-time assessment of ECM changes and lung tissue damage [ 128 ]. Innovations in imaging technologies are expected to enable clinicians to visualize ECM alterations and lung injury with unprecedented detail and in real time [ 129 ].…”

Section: Clinical Implications and Future Perspectivesmentioning

confidence: 99%

Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review

Al-Husinat,

Azzam,

Al Sharie

et al. 2024

Crit Care

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Background Mechanical ventilation, a lifesaving intervention in critical care, can lead to damage in the extracellular matrix (ECM), triggering inflammation and ventilator-induced lung injury (VILI), particularly in conditions such as acute respiratory distress syndrome (ARDS). This review discusses the detailed structure of the ECM in healthy and ARDS-affected lungs under mechanical ventilation, aiming to bridge the gap between experimental insights and clinical practice by offering a thorough understanding of lung ECM organization and the dynamics of its alteration during mechanical ventilation. Main text Focusing on the clinical implications, we explore the potential of precise interventions targeting the ECM and cellular signaling pathways to mitigate lung damage, reduce inflammation, and ultimately improve outcomes for critically ill patients. By analyzing a range of experimental studies and clinical papers, particular attention is paid to the roles of matrix metalloproteinases (MMPs), integrins, and other molecules in ECM damage and VILI. This synthesis not only sheds light on the structural changes induced by mechanical stress but also underscores the importance of cellular responses such as inflammation, fibrosis, and excessive activation of MMPs. Conclusions This review emphasizes the significance of mechanical cues transduced by integrins and their impact on cellular behavior during ventilation, offering insights into the complex interactions between mechanical ventilation, ECM damage, and cellular signaling. By understanding these mechanisms, healthcare professionals in critical care can anticipate the consequences of mechanical ventilation and use targeted strategies to prevent or minimize ECM damage, ultimately leading to better patient management and outcomes in critical care settings.

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Section: Clinical Implications and Future Perspectivesmentioning

confidence: 99%

Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review

Al-Husinat,

Azzam,

Al Sharie

et al. 2024

Crit Care

View full text Add to dashboard Cite

show abstract

“…The primary constituents of this ECM are collagen fibres (collagen type I, II, III, V and IX) and elastin, which provide elasticity and mechanical strength. [59][60][61] Other constituents include fibronectin, proteoglycans and glycosaminoglycans, which further maintain structural support, cell adhesion and local water homeostasis. 60,62 In terms of cellular constituents, this ECM hosts fibroblasts which maintain and remodel the surrounding ECM including the BM.…”

Section: Lung Physiologymentioning

confidence: 99%

“…[59][60][61] Other constituents include fibronectin, proteoglycans and glycosaminoglycans, which further maintain structural support, cell adhesion and local water homeostasis. 60,62 In terms of cellular constituents, this ECM hosts fibroblasts which maintain and remodel the surrounding ECM including the BM. In addition, local immune cells, mainly alveolar macrophages, are located here to provide a first line of defence against potential pathogens.…”

Section: Lung Physiologymentioning

confidence: 99%