Imatinib associated temporal bone osteonecrosis

McKenna, Dominic; Reddy, Ekambar

doi:10.1002/ccr3.7611

Cited by 2 publications

(1 citation statement)

References 8 publications

(18 reference statements)

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“…McKenna et al [24] reported the case of a 75-year-old man who experienced bilateral ear pain and discharge for four months; he was treated with imatinib for a gastrointestinal stromal tumor. Subsequent examinations uncovered bilateral bony erosion and necrosis at the base of both external auditory canals.…”

Section: Imatinibmentioning

confidence: 99%

Exploring the Impact of Novel Anti-Cancer Therapies on Jaw Osteonecrosis and Other Bones: A Comprehensive Review

Konarski,

Poboży,

Konarska

et al. 2024

JCM

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Osteonecrosis is a debilitating condition characterized by the loss of blood supply to the bones, leading to bone death. This condition can impact various bones, including the jaw, which significantly affects patients’ quality of life by causing difficulties in swallowing, feeding, chewing, and speaking, along with swollen, painful mucous membranes and chronic sinusitis. Osteonecrosis can arise due to treatment with antiresorptive drugs. However, there is a growing number of reports of osteonecrosis following novel targeted anti-cancer treatments, such as tyrosine kinase inhibitors (TKIs) and biological therapies. The pathogenesis of osteonecrosis is linked to the side effects of the antiangiogenic mechanisms of these medications, leading to a disrupted blood flow. Our review aims to examine recent insights into osteonecrosis triggered by new anti-cancer drugs. Most reports focus on the osteonecrosis of the jaw (ONJ); however, we discovered that some authors have described cases of osteonecrosis affecting the femoral head or elbow following novel anti-cancer treatments. Prevention is a key component in managing osteonecrosis. Therefore, a comprehensive risk assessment should always be performed before and during anti-cancer therapy.

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Section: Imatinibmentioning

confidence: 99%