Imbalance between dopamine and serotonin caused by neonatal habenula lesion

Lee, Young‐A; Kim, Yujeong; Lee, Jusung; Lee, Sang‐Hyun; Goto, Yukiori

doi:10.1016/j.bbr.2021.113316

Cited by 6 publications

(5 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NHLs also cause an assortment of neural alterations, such as a smaller PFC volume ( Lee and Goto, 2011 ) and abnormally augmented amygdala–PFC connectivity ( Kim et al, 2021 ), which are also consistent with those found in ADHD individuals ( Plessen et al, 2006 ; Shaw et al, 2007 ; Batty et al, 2010 ; Posner et al, 2011 ; Batty et al, 2015 ; Van Dessel et al, 2018 ). We further found that tissue concentrations of DA and 5-HT were balanced in mesocorticolimbic regions of normal rats, but these levels were disrupted in NHL rats, suggesting that imbalances between DA and 5-HT may be more important than alterations in DA or 5-HT levels alone in NHL-induced behavioral alterations ( Lee et al, 2021 ). There has been only one human neuroimaging study that investigated habenular deficits in ADHD subjects to date ( Arfuso et al, 2019 ).…”

Section: Habenula In Adhd and Mddmentioning

confidence: 86%

The Habenula in the Link Between ADHD and Mood Disorder

Lee

Goto

2021

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

Attention-deficit/hyperactivity disorder (ADHD) is a childhood-onset, neurodevelopmental disorder, whereas major depressive disorder (MDD) is a mood disorder that typically emerges in adulthood. Accumulating evidence suggests that these seemingly unrelated psychiatric disorders, whose symptoms even appear antithetical [e.g., psychomotor retardation in depression vs. hyperactivity (psychomotor acceleration) in ADHD], are in fact associated with each other. Thus, individuals with ADHD exhibit high comorbidity with MDD later in life. Moreover, genetic studies have shown substantial overlaps of susceptibility genes between ADHD and MDD. Here, we propose a novel and testable hypothesis that the habenula, the epithalamic brain region important for the regulation of monoamine transmission, may be involved in both ADHD and MDD. The hypothesis suggests that an initially hypoactive habenula during childhood in individuals with ADHD may undergo compensatory changes during development, priming the habenula to be hyperactive in response to stress exposure and thereby increasing vulnerability to MDD in adulthood. Moreover, we propose a new perspective on habenular deficits in psychiatric disorders that consider the habenula a neural substrate that could explain multiple psychiatric disorders.

show abstract

Section: Habenula In Adhd and Mddmentioning

confidence: 86%

The Habenula in the Link Between ADHD and Mood Disorder

Lee

Goto

2021

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Changes in the concentrations of dopamine and 5-HT were observed across parts of the mesocorticolimbic region in rats with neonatal habenula lesions ( 155 ). Spontaneous activity in the LHb is enhanced by dopamine receptor activation ( 156 ).…”

Section: Changes In Lateral Habenula Synaptic Transmission During The...mentioning

confidence: 99%

Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence

Zhang

Cui

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

Despite extensive research in recent decades, knowledge of the pathophysiology of depression in neural circuits remains limited. Recently, the lateral habenula (LHb) has been extensively reported to undergo a series of adaptive changes at multiple levels during the depression state. As a crucial relay in brain networks associated with emotion regulation, LHb receives excitatory or inhibitory projections from upstream brain regions related to stress and cognition and interacts with brain regions involved in emotion regulation. A series of pathological alterations induced by aberrant inputs cause abnormal function of the LHb, resulting in dysregulation of mood and motivation, which present with depressive-like phenotypes in rodents. Herein, we systematically combed advances from rodents, summarized changes in the LHb and related neural circuits in depression, and attempted to analyze the intrinsic logical relationship among these pathological alterations. We expect that this summary will greatly enhance our understanding of the pathological processes of depression. This is advantageous for fostering the understanding and screening of potential antidepressant targets against LHb.

show abstract

“…However, the analgesic mechanisms of SH003 on paclitaxel have not yet been assessed. Among the three components of SH003, Astragalus membranaceus has been reported to modulate serotonin and noradrenaline levels in the brain [37,38]. Therefore, we may assume that SH003 and its components could suppress paclitaxel-induced neuropathic pain via serotonin or noradrenaline modulation.…”

Section: Introductionmentioning

confidence: 99%

Analgesic Effect of SH003 and Trichosanthes kirilowii Maximowicz in Paclitaxel-Induced Neuropathic Pain in Mice

Lee

Kim

et al. 2022

CIMB

View full text Add to dashboard Cite

Pacliatxel is a taxol-based chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use. Although several drugs are prescribed to attenuate neuropathies, no optimal treatment is available. Thus, in our study, we analyzed whether SH003 and its sub-components could alleviate paclitaxel-induced neuropathic pain. Multiple paclitaxel injections (cumulative dose 8 mg/kg, i.p.) induced cold and mechanical allodynia from day 10 to day 21 after the first injection in mice. Oral administration of SH003, an herbal mixture extract of Astragalus membranaceus, Angelica gigas, and Trichosantheskirilowii Maximowicz (Tk), dose-dependently attenuated both allodynia. However, when administered separately only Tk decreased both allodynia. The effect of Tk was shown to be mediated by the spinal noradrenergic system as intrathecal pretreatment with α1- and α2-adrenergic-receptor antagonists (prazosin and idazoxan), but not 5-HT1/2, and 5-HT3-receptor antagonists (methysergide and MDL-72222) blocked the effect of Tk. The spinal noradrenaline levels were also upregulated. Among the phytochemicals of Tk, cucurbitacin D was shown to play a major role, as 0.025 mg/kg (i.p.) of cucurbitacin D alleviated allodynia similar to 500 mg/kg of SH003. These results suggest that Tk should be considered when treating paclitaxel-induced neuropathic pain.

show abstract

Imbalance between dopamine and serotonin caused by neonatal habenula lesion

Cited by 6 publications

References 48 publications

The Habenula in the Link Between ADHD and Mood Disorder

The Habenula in the Link Between ADHD and Mood Disorder

Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence

Analgesic Effect of SH003 and Trichosanthes kirilowii Maximowicz in Paclitaxel-Induced Neuropathic Pain in Mice

Contact Info

Product

Resources

About