Imbalanced plasma ACE and ACE2 level in the uremic patients with cardiovascular diseases and its change during a single hemodialysis session

Yang, Chung-Wei; Lu, Li Che; Chang, Chi-Ching; Cho, Ching Chang; Hsieh, Wen Yeh; Tsai, Chun-Ming; Lin, Yi; Lin, Chih‐Sheng

doi:10.1080/0886022x.2017.1398665

Cited by 23 publications

(20 citation statements)

References 43 publications

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“…Likewise, uremic patients under chronic haemodialysis exhibited an increase in ACE and Ang II plasmatic levels, whereas ACE2 and Ang (1–7) levels were lower when compared to controls [ 90 ]. That imbalanced ACE/ACE2 ratio was more severe in the haemodialysis patients with cardiovascular disease.…”

Section: Comorbidities and Ace/ace2 Balance Disruptionmentioning

confidence: 99%

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

Beyerstedt

Casaro

Rangel

2021

Eur J Clin Microbiol Infect Dis

631

481

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Section: Comorbidities and Ace/ace2 Balance Disruptionmentioning

confidence: 99%

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

Beyerstedt

Casaro

Rangel

2021

Eur J Clin Microbiol Infect Dis

631

481

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“…Further studies of cellular angiotensin-converting enzyme 2 expression in patients on maintenance hemodialysis could explain this effect since decreased angiotensin-converting enzyme 2 activity has been reported in this population. [5][6][7] SUPPLEMENTARY MATERIAL Supplementary File (PDF) Table S1. Demographics, comorbidities and presentation of the cohort.…”

Section: Treatment Impact On Covid-19 Evolution In Hemodialysis Patientsmentioning

confidence: 99%

mentioning

confidence: 99%

Treatment impact on COVID-19 evolution in hemodialysis patients

Chawki

Buchard²,

Sakhi

et al. 2020

Kidney International

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“…Reduced ACE2 shifts the balance in the RAS toward the Ang II/AT1 Raxis, resulting in the progression of cardiometabolic dysfunction. 41,42 We showed that CRP dose-dependently increases the expressions of ACE, AngII and AT1R proteins, but inhibits ACE2 expression in both adipocytes and VSMCs, suggesting the detrimental effect of CRP on vasculatures is connected with an imbalance of RAS. Ang II/ATR1 signalling also leads to the activation of several downstream kinase pathways, such as extracellular signal-regulated kinases (ERK)1/2.…”

Section: Discussionmentioning

confidence: 90%

<p>Detrimental Effect of C-Reactive Protein on the Cardiometabolic Cells and Its Rectifying by Metabolic Surgery in Obese Diabetic Patients</p>

Sun

Zhao

et al. 2020

DMSO

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Background: High-sensitivity C-reactive protein (hs-CRP) has been regarded as a biomarker of low-degree inflammation in illness; however, whether CRP exerts its pathogenic effect on the cardiometabolic system remains unknown. Aside from the beneficial effects of metabolic surgery on cardiometabolic system, its impact on inflammation still worth examining. Thus, this study aims to investigate the effect of CRP on adipose and vascular cells, and their responses to metabolic surgery in obese diabetic patients. Patients and Methods: The expression of CRP and RAS-and ERK-related factors in the adipocytes and VSMCs were measured. Obese patients with type 2 diabetes who underwent metabolic surgery were followed up for 2 years thereafter. Laboratory tests, which included serum hs-CRP levels and visceral fat thickness (VFT), were obtained before and after surgery. Results: CRP administration significantly and dose-dependently increased the intracellularfree calcium concentration ([Ca2+]i) in cultured adipocytes and in the VSMCs. CRP administration significantly increased ACE, Ang II, AT1R and pERK expressions, but reduced ACE2 expression in both the adipocytes and VSMCs. Clinical study showed that VFT was closely associated with serum hs-CRP. Furthermore, VFT and serum hs-CRP were found to be highly associated with blood pressure. Finally, metabolic surgery remarkably decreased blood pressure, visceral fat and serum hs-CRP levels. Conclusion: CRP has a detrimental effect on cardiometabolic cells, aside from functioning merely as a biomarker. Serum hs-CRP levels are highly associated with hypertension and visceral obesity, which can be antagonized by metabolic surgery in obese diabetic patients.

show abstract

Imbalanced plasma ACE and ACE2 level in the uremic patients with cardiovascular diseases and its change during a single hemodialysis session

Abstract: Pathogenically imbalanced circulating ACE/ACE2 was detected in the HD patients, particularly those with CVD. HD session could increase ACE/Ang II/AT1R axis and decrease ACE2/Ang-(1-7)/Mas axis activity in the circulation of HD patients with CVD.

Cited by 23 publications

References 43 publications

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

Treatment impact on COVID-19 evolution in hemodialysis patients

<p>Detrimental Effect of C-Reactive Protein on the Cardiometabolic Cells and Its Rectifying by Metabolic Surgery in Obese Diabetic Patients</p>

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