Imbalances Between Tumor Necrosis Factor-α and Its Soluble Receptor Forms, and Interleukin-1β and Interleukin-1 Receptor Antagonist in BAL Fluid of Cavitary Pulmonary Tuberculosis

Tsao, Thomas Chang Yao; Hong, Ji‐Hong; Li, Lifu; Hsieh, Meng‐Jer; Liao, Shuen‐Kuei; Chang, Kenneth S. S.

doi:10.1378/chest.117.1.103

Cited by 95 publications

(73 citation statements)

References 27 publications

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“…The importance of a balanced immune response has been described in detail as regards the regulation of IL-1b and IL-1RA, which competitively block the binding of IL-1a and IL-1b without inducing a cellular signal of their own [22]. Patients with active pulmonary tuberculosis and large necrotic cavities are characterised by elevated IL-1b/IL-1RA ratios in BALF, giving rise to the assumption that an imbalance in IL-1b/IL-1RA contributes to severe tissue damage [10]. The present results indicate that AMs and PBMCs from healthy volunteers have a greater capacity to balance IL-1b activity by increased production of IL-1RA.…”

Section: Discussionmentioning

confidence: 99%

“…Apart from the beneficial effects of IL-1b and TNF-a in promoting inflammatory cell accumulation and stimulating the antimicrobial capacity of neutrophils [8], an imbalance between pro-and anti-inflammatory cytokines in the pulmonary compartment might contribute to airway wall remodelling and fibrosis of the small airways. The significance of the relationship between IL-1b, TNF-a and their anti-inflammatory counterparts IL-1 receptor antagonist (IL-1RA) and soluble TNF receptor I has been well established in lung diseases such as sarcoidosis [9] and pulmonary tuberculosis [10]. To date, data concerning the effect of bacterial pathogens on the balance between pro-and anti-inflammatory cytokines in COPD patients are lacking.…”

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confidence: 99%

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Imbalanced secretion of IL‐1β and IL‐1RA inChlamydia pneumoniae-infected mononuclear cells from COPD patients

Rupp

Kothe²,

Mueller³

et al. 2003

Eur Respir J

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Balanced secretion of pro-and anti-inflammatory cytokines is essential in limiting pulmonary inflammation in respiratory infections. It was hypothesised that, in acute infection with Chlamydia pneumoniae, mononuclear cells from chronic obstructive pulmonary disease (COPD) patients lack the opportunity to compensate for the inflammatory immune response by secreting adequate amounts of anti-inflammatory cytokines.Alveolar macrophages (AMs) and peripheral blood mononuclear cells (PBMCs) from eight COPD patients and eight healthy controls were infected with C. pneumoniae in order to determine interleukin (IL)-1b, IL-1 receptor antagonist (IL-1RA) and IL-8 expression and messenger ribonucleic acid levels.Secretion of IL-1b was significantly enhanced in AMs (six-fold) and PBMCs (four-fold) from COPD patients after infection with C. pneumoniae. Compared to the control group, release of its anti-inflammatory counterpart IL-1RA was diminished in COPD patients, resulting in a significantly higher IL-1b/IL-1RA ratio in C. pneumoniae-infected AMs and PBMCs from COPD patients.Mononuclear cells from chronic obstructive pulmonary disease patients have less capacity for balancing the pro-inflammatory immune response caused by Chlamydia pneumoniae infection than those from healthy controls. These findings suggest that, during acute exacerbation with intracellular pathogens, chronic obstructive pulmonary disease patients are predisposed to inflammatory changes in the lungs. Eur Respir J 2003; 22: 274-279.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Imbalanced secretion of IL‐1β and IL‐1RA inChlamydia pneumoniae-infected mononuclear cells from COPD patients

Rupp

Kothe²,

Mueller³

et al. 2003

Eur Respir J

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“…Cellular immune responses triggered by these inflammatory cytokines activate typical immune defense mechanisms against MTB inflammation [4][5][6]. TNF-alpha and IL-1 beta exert well documented effects on the vascular endothelium, promoting endothelial damage and endarteritis.…”

Section: Introductionmentioning

confidence: 99%

Influence of prednisone on serum level of tumor necrosis factor alpha, interferon gamma and interleukin-1 beta, in active pulmonary tuberculosis

Rybacka-Chabros

Pietrzak

Milanowski

et al. 2014

Polish Journal of Public Health

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Aim. The aim of the study was a potential impact of prednisone on the early immune response in HIV-negative young adults with active pulmonary tuberculosis, during the first four weeks of treatment.Material and methods. The study included 38 adults, aged 18-39 years, with active pulmonary tuberculosis. The first group of patients received only anti-tuberculosis chemotherapy whereas the second group of patients was administered antituberculosis chemotherapy and 20 mg prednisone, once daily. Serum levels of tumor necrosis factor-alpha, interferon-gamma and interleukin 1-beta were measured using ELISA kits before treatment initiation as well after two and four weeks of treatment, in both study groups.Results. The highest serum levels of evaluated cytokines were observed before treatment initiation. Serum levels of cytokines were significantly decreased in patients who received anti-tuberculosis drugs and prednisone, compare to those not treated with prednisone (p<0.001), in all study periods.Conclusions. Adjunctive therapy, like 20 mg prednisone daily, remarkably inhibited the secretion of inflammatory cytokines during the early stage of active pulmonary tuberculosis in HIV-negative young adults, which is likely to be beneficial for this group of patients.

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“…Patients with pulmonary TB have higher levels of proinflammatory cytokines IL-1, IL-6, TNF-, IL-8, and their inhibitors TNFRI, IL-1Ra and TGF- in sera and BAL fluid than healthy controls and TB contacts (Zhang et al, 1995;Tsao et al, 1999;Tsao et al, 2000;Nemeth et al, 2011). Among TB patients, serum levels of TNF- and TGF- are significantly higher in patients with advanced TB compared to patients with mild-moderate TB (Fiorenza et al, 2005).…”

Section: Inflammatory Responses In Patients With Pulmonary Tbmentioning

confidence: 99%

“…Importantly, the ratios of TNF- to sTNF-RI and IL-1 to IL-1RA in the BAL fluids are also higher in patients with large cavity. Thus, a role for the relative abundance of TNF- and IL-1 in tissue necrosis and cavity formation was suggested (Tsao et al, 2000).…”

Section: Inflammatory Responses In Patients With Pulmonary Tbmentioning

confidence: 99%

Inflammation and Immunopathogenesis of Tuberculosis Progression

Lyadova¹

2012

Understanding Tuberculosis - Analyzing the Origin of Mycobacterium Tuberculosis Pathogenicity

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Imbalances Between Tumor Necrosis Factor-α and Its Soluble Receptor Forms, and Interleukin-1β and Interleukin-1 Receptor Antagonist in BAL Fluid of Cavitary Pulmonary Tuberculosis

Cited by 95 publications

References 27 publications

Imbalanced secretion of IL‐1β and IL‐1RA inChlamydia pneumoniae-infected mononuclear cells from COPD patients

Imbalanced secretion of IL‐1β and IL‐1RA inChlamydia pneumoniae-infected mononuclear cells from COPD patients

Influence of prednisone on serum level of tumor necrosis factor alpha, interferon gamma and interleukin-1 beta, in active pulmonary tuberculosis

Inflammation and Immunopathogenesis of Tuberculosis Progression

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