Imidazole-Based Monomer as Functional Unit for the Specific Detection of Paraxanthine in Aqueous Environments

Anastasiadi, Rozalia-Maria; Traldi, Federico; Resmini, Marina

doi:10.3390/chemosensors10080301

Cited by 3 publications

(1 citation statement)

References 69 publications

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“…We used HDRP in organic solvents for the synthesis of NGs for applications in catalysis 31 , sensing 32 and drug delivery 33 , focusing on the relationship between formulation and properties, their interaction with biomolecules in vitro 34 , and the effect of different synthetic procedures 35 .…”

Section: Introductionmentioning

confidence: 99%

Sustainable and Surfactant-Free Synthesis of Negatively Charged Acrylamide Nanogels for Biomedical Applications

Mazzali,

Rath,

Röntgen

et al. 2024

Preprint

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Nanogels offer unique advantages, like high surface-to-volume ratio, scalable synthetic methods and easily tailored formulations, that allow to control size and introduce stimuli-responsive properties. Their potential for drug delivery is significant due to their biocompatibility, high drug loading capacity, and controlled and sustained drug release, but the development of greener and sustainable processes, in particular the replacement of organic solvents with water, is essential for large-scale applications. Here we report our results on the synthesis in water of covalently crosslinked acrylamide-based nanogels, both neutral and negatively charged, with varying amounts of acryloyl-L-proline, using a high-dilution radical polymerization technique without the need for surfactants. The use of a water-based synthesis resulted in nanogels with high monomer conversions and chemical yields, as well as lower polydispersity and smaller particle sizes for the negatively charged nanogels. This results in a more efficient synthetic methodology, with reduced loss of starting materials, higher potential for scalability and reduction in costs. The suitability of these nanogels for biomedical applications was supported by cytotoxicity studies showing no significant reduction in viability on a human neuroblastoma cell line.

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Section: Introductionmentioning

confidence: 99%

Sustainable and Surfactant-Free Synthesis of Negatively Charged Acrylamide Nanogels for Biomedical Applications

Mazzali,

Rath,

Röntgen

et al. 2024

Preprint

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Advances in the selection of functional monomers for molecularly imprinted polymers: A review

Niu,

Du,

et al. 2024

J of Separation Science

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Molecularly imprinted polymers, a type of special polymer materials, are widely used in biosensing and other fields due to their ability to specifically recognize target molecules, often called “artificial receptors.”. Nowadays, researchers are constantly exploring new design and synthesis methods for molecularly imprinted materials to improve the selectivity and sensitivity of molecularly imprinted materials. Among them, the selection of functional monomers has attracted great attention. This review comprehensively analyzes and discusses the selection methods of functional monomers. The most commonly used functional monomers among different types of templates are screened based on the structural properties of the template molecules, including the selection of functional monomers among ion‐imprinted polymers, protein‐imprinted polymers, and bacterial imprinted polymers. The rich binding sites and functional group types of multifunctional monomers are also highlighted to advance the development of molecular imprinting technology. The article further explores the current challenges and prospects in the selection of functional monomers and emphasizes multiplex experiments and computer simulations as important directions for future research. This review provides comprehensive information and constructive guidelines for researchers in selecting functional monomers in areas such as analytical chemistry and biosensors.

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NIPAm Microgels Synthesised in Water: Tailored Control of Particles’ Size and Thermoresponsive Properties

Rath,

Mazzali,

Zarbakhsh

et al. 2024

Polymers

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Microgels, combining the properties of hydrogels and microparticles, are emerging as versatile materials for varied applications such as drug delivery and sensing, although the precise control of particle size remains a challenge. Advances in synthetic methodologies have provided new tools for tailoring of properties, however costs and scalability of the processes remains a limitation. We report here the water-based synthesis of a library of N-isopropylacrylamide-based microgels covalently crosslinked with varying contents of N,N′-methylenebisacrylamide. The results highlight the versatility of water as a synthetic medium, which yields large and monodisperse microgels, with excellent control over size. Dynamic light scattering data demonstrate that by increasing the total monomer concentration from 1 to 3 wt%, the particle size is increased by up to 4.9-fold. Crosslinker content allows fine-tuning of microgel size, with greater relevance for functionalised microgels. Functional co-monomers such as N-(3-aminopropyl)methacrylamide hydrochloride and N-(hydroxymethyl)acrylamide are shown to influence size and thermoresponsive behaviour, with hydrogen-bonding monomers reducing particle size and increasing the volume phase transition temperature by 2 °C. Positively charged monomers show a size reduction upon heating but provide colloidal stability at temperatures up to 60 °C. These findings emphasize the importance of tailoring synthetic conditions and formulations to optimize microgel properties for specific applications.

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Imidazole-Based Monomer as Functional Unit for the Specific Detection of Paraxanthine in Aqueous Environments

Cited by 3 publications

References 69 publications

Sustainable and Surfactant-Free Synthesis of Negatively Charged Acrylamide Nanogels for Biomedical Applications

Sustainable and Surfactant-Free Synthesis of Negatively Charged Acrylamide Nanogels for Biomedical Applications

Advances in the selection of functional monomers for molecularly imprinted polymers: A review

NIPAm Microgels Synthesised in Water: Tailored Control of Particles’ Size and Thermoresponsive Properties

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