Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases

Vanda, David; Zajdel, Paweł; Soural, Miroslav

doi:10.1016/j.ejmech.2019.111569

Cited by 68 publications

(48 citation statements)

References 172 publications

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“…Among the four imidazopyridine isomers, imidazo[1,2‐ a ]pyridine is the most common through its wide variety of biological activities. [ 15 ] This scaffold is a key element in a number of prominent marketed pharmaceuticals such as Zolpidem and Alpidem, used worldwide for the treatment of insomnia and associated sleeping disorders. [ 16 ] Therefore, it is not surprising to note that C–H bond functionalization of the imidazo[1,2‐ a ]pyridine core has been the focus of intensive work [ 17 ] with recent interest in visible‐light photoredox catalysis concentrating on the formation of C–C, C–O, C–N and C–S bonds.…”

Section: Methodsmentioning

confidence: 99%

Three‐Component C–H Bond Sulfonylation of Imidazoheterocycles by Visible‐Light Organophotoredox Catalysis

et al. 2020

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The first entirely visible‐light photoredox catalyzed sulfonylation of imidazoheterocycles has been developed. This transformation demonstrates an efficient C–H functionalization for the straightforward synthesis of novel C‐3 sulfonylated imidazoheterocycles from various imidazopyridines and diaryliodonium salts with different electronic and steric properties and easy to handle DABCO‐bis(sulfur dioxide). The reaction proceeds in moderate to good yields under mild conditions at room temperature using the inexpensive organophotocatalyst EosinY·Na2 and shows a high functional group tolerance (37 examples).

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Section: Methodsmentioning

confidence: 99%

Three‐Component C–H Bond Sulfonylation of Imidazoheterocycles by Visible‐Light Organophotoredox Catalysis

et al. 2020

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“…From the past five years some critical reviews have been published concerning about the molecular recognition, selectivity patterns and multi‐targeted MAO inhibitors for several CNS disorders [12–21] . The current review is based on the various synthetic methods and structure activity relationships (SARs) for the diverse class of heterocyclic molecules against MAO‐B.…”

Section: Introductionmentioning

confidence: 99%

An Update of Synthetic Approaches and Structure‐Activity Relationships of Various Classes of Human MAO‐B Inhibitors

2021

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The selective MAO‐B inhibition is greatly influenced by the degradation pathways of various biogenic amines. So the design and development of diverse class of MAO‐B inhibitors are considered as an effective adjuvant therapy of various neurodegenerative disorders. Recent studies documented that introduction of an electron rich linker between two aryl or heteroaryl rings explored as a promising structural framework of the inhibition of MAO‐B. The electrophilicity and flexibility character of the linker can anchor different orientation of binding mode in both entrance and substrate cavity of MAO‐B. The current review focus on the design aspect, synthetic route and structure activity relationships (SARs) various class of selective MAO‐B inhibitors like chalcones, coumarins, chromones, pyrazolines, xanthines, isatins, FDA approved analogs etc.

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“…The drug zolpidem is used to restore brain function after the brain injury of a person. It can bind selectively to GABA‐ ω 1 receptor and carries out the required enzymatic reactions to alter the functional activity of the damaged area of the brain [19–21] . Necopidem and saripidem drugs are related to that of alpidem and zolpidem and are used as a sedative and anxiolytic drug [20,22–24] .…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in Transition‐Metal‐Catalyzed Regioselective Functionalization of Imidazo[1, 2‐a]pyridine

Konwar

Bora

2021

ChemistrySelect

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Imidazo[1,2‐a]pyridine is an important nitrogen‐containing heterocycle from biological as well as pharmaceutical point of view. In recent years, regioselective functionalization of C−H bond of imidazo[1,2‐a]pyridine is extensively carried out using various transition metal‐based catalysts. Alkenylation, arylation, dual dehydrogenative annulations, formylation, thiolation, aminomethylation, dicarbonylation, phosphonylation along with other significant reactions are the progress in the field of functionalization of imidazopyridine. Most of these functionalizations are done at the C‐3 position of imidazo[1,2‐a]pyridine scaffold and in addition to that development towards C‐5 regioselectivity is also available. In this review, our aim is to present the recent advances for the functionalization of imidazo[1,2‐a]pyridine employing transition metal catalysts under significant reaction conditions.

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Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases

Cited by 68 publications

References 172 publications

Three‐Component C–H Bond Sulfonylation of Imidazoheterocycles by Visible‐Light Organophotoredox Catalysis

Three‐Component C–H Bond Sulfonylation of Imidazoheterocycles by Visible‐Light Organophotoredox Catalysis

An Update of Synthetic Approaches and Structure‐Activity Relationships of Various Classes of Human MAO‐B Inhibitors

Recent Developments in Transition‐Metal‐Catalyzed Regioselective Functionalization of Imidazo[1, 2‐a]pyridine

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