The interdisciplinary approach to dental treatment is associated with an increasing number of severe dental anomalies. One of the most common dental anomalies according to modern research is congenital absence of teeth. This pathology requires individual approach and complex treatment using digital dentistry. Dental practice experience of the authors shows that interdisciplinary approach in treatment of patients with congenital absence of maxillary lateral incisors should include the work of oral surgeon, orthodontist, prosthodontist, periodontist and dental technician. the aim of the research was to increase effectiveness and aesthetic results of the treatment of patients with congenital congenital absence of maxillary lateral incisors using dental implants, orthodontic treatment and digital prosthetics. Materials and methods. 84 patients with congenital absence of maxillary lateral incisors were treated with orthodontic and dental implants in the area of the missing teeth from 1998 to 2022. a total of 32 patients (10 men and 22 women,16 to 35 years old) underwent the complete treatment with previous orthodontic treatment, braces on the top or bottom teeth and dental implants in 1.2 and 2.2. Sixty-four implants of different systems – Astra Tech, Nobel Biocare, Straumann, Mis, Conmet, STI-OL, STAS, RADIX and others were placed. Patients were evaluated at all stages of treatment. Patients were followed up for more than 20 years. Results. the number of successful cases of rehabilitation of patients with congenital absence of teeth was 93.75%. Total failure rate was in the first follow-up year (1999) and was eliminated. Conclusions. Use of the interdisciplinary approach, special dental implant planning software, template-assisted guided surgery, metal-free prosthetic restorations according to CAD/CAM technology in treatment of patients with congenital absence of maxillary lateral incisors allows to achieve effective functional and esthetic of the dentoalveolar structure.